Article
Biology
Ya-tang Li, Markus Meister
Summary: The superior colliculus in the brain is a crucial visual processing station that receives input from various types of retinal ganglion cells. Through recording mouse superficial SC neurons, we identified 24 functional types using an unsupervised clustering algorithm. These types can be grouped into two categories: one that responds similarly to retinal ganglion cells and another with more diverse and specialized stimulus selectivity. Cells of the same functional type tend to cluster together in anatomical space, and the visual representation in the SC has lower dimensionality compared to the retina, suggesting a sifting process along the visual pathway.
Article
Ophthalmology
Xi Wang, Alex S. Baldwin, Robert F. Hess
Summary: The study examined how an imbalance in input strength received from the eyes affects stereopsis, finding that only fusion imbalance is correlated with stereoacuity, while threshold imbalance and masking imbalance show no significant correlation. The results also suggest that there are multiple types of sensory eye dominance assessed by different tasks, with imbalances in dominance leading to biases in fused percepts being correlated with stereoacuity.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Neurosciences
Scott A. Smyre, Naomi L. Bean, Barry E. Stein, Benjamin A. Rowland
Summary: The deep layers of the superior colliculus (SC) are important for detecting and guiding responses to salient events in the environment. Neurons in the SC can enhance their responses to events detected by multiple sensory modalities. Modulatory dynamics induced by stimulus repetition are specific to sensory modalities.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Anna M. Lavezzi, Riffat Mehboob, Francesco Piscioli, Teresa Pusiol
Summary: The aim of this study was to investigate the involvement of the mesencephalic superior colliculus (SC) in the pathogenetic mechanism of SIDS. In-depth neuropathological investigations showed alterations in the laminar arrangement of the SC deep layers in 69% of SIDS cases, but never in the controls. These SC anomalies represent a new step in understanding the pathogenetic process of SIDS.
Article
Biology
Sebastian H. Zahler, David E. Taylor, Joey Y. Wong, Julia M. Adams, Evan H. Feinberg
Summary: The study shows that mice can make sensory-guided gaze shifts involving both eye movements and attempted head movements. The flexibility of mouse gaze shifts is revealed under head-fixed conditions, offering insights into the characteristics of mouse gaze shifts and laying the foundation for studying the coupling between head and eye movements.
Article
Multidisciplinary Sciences
Nora L. Benavidez, Michael S. Bienkowski, Muye Zhu, Luis H. Garcia, Marina Fayzullina, Lei Gao, Ian Bowman, Lin Gou, Neda Khanjani, Kaelan R. Cotter, Laura Korobkova, Marlene Becerra, Chunru Cao, Monica Y. Song, Bin Zhang, Seita Yamashita, Amanda J. Tugangui, Brian Zingg, Kasey Rose, Darrick Lo, Nicholas N. Foster, Tyler Boesen, Hyun-Seung Mun, Sarvia Aquino, Ian R. Wickersham, Giorgio A. Ascoli, Houri Hintiryan, Hong-Wei Dong
Summary: This study provides a comprehensive understanding of how the superior colliculus (SC) receives diverse cortical inputs to drive a variety of behaviors. By mapping cortico-tectal projections, the authors identified distinct zones within the SC and characterized the connectivity and morphology of neurons in each zone, shedding light on the role of SC in goal-directed behaviors.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Mengting Liu, Fenghua Xie, Jinsheng Dai, Juan Zhang, Kexin Yuan, Ningyu Wang
Summary: The inferior colliculus (IC) is a central hub along the auditory pathway. It not only processes auditory information but also responds to multimodal stimuli. However, the sources of these non-auditory inputs are still unknown.
NEUROSCIENCE LETTERS
(2023)
Review
Neurosciences
Xue Liu, Hongren Huang, Terrance P. Snutch, Peng Cao, Liping Wang, Feng Wang
Summary: This review provides insight into the phenotypic diversity of SC neurons, their intrinsic circuits, and long-projection targets. It contributes to the understanding of SC functioning and the pathology associated with SC dysfunction.
NEUROSCIENCE BULLETIN
(2022)
Article
Behavioral Sciences
James M. Shine
Summary: The thalamus and superior colliculus play crucial roles in higher-order functions of the brain, such as working memory and attention. The connections between them and their location within the brain circuitry shape complex dynamics and conscious awareness. This perspective leads to testable predictions about the interactions between different regions within the thalamus.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Computer Science, Information Systems
Huan Zhang, Zhaoquan Gu, Hao Tan, Le Wang, Ziqi Zhu, Yushun Xie, Jianxin Li
Summary: The vulnerability of DNNs to adversarial attacks has been a concerning issue, and researchers are looking for methods to improve their robustness. Most existing methods are empirical and can only handle known attack environments and specific conditions, while certified defense methods provide theoretical proofs and worst-case adversarial robustness. However, the study on certified defenses is currently limited, and the existing certified defense methods rely on unrealistic prior knowledge and assumptions. In this paper, a model-agnostic and attack-agnostic certified defense method is proposed, which implements denoising and refactoring of input samples. The proposed method shows superior performance in balancing prediction accuracy and robustness against adversarial attacks compared to state-of-the-art defense methods.
INFORMATION SCIENCES
(2023)
Article
Computer Science, Information Systems
Huan Zhang, Zhaoquan Gu, Hao Tan, Le Wang, Ziqi Zhu, Yushun Xie, Jianxin Li
Summary: This paper proposes a model-agnostic and attack-agnostic certified defense method that implements denoising and refactoring of input samples through the Makser and the Purifier. The method shows superior performance in balancing robustness and prediction accuracy compared to other methods, as demonstrated by theoretical proofs and experiments.
INFORMATION SCIENCES
(2023)
Letter
Clinical Neurology
Thomas Nyffeler, Brigitte C. Kaufmann, Dario Cazzoli
Summary: This case report details a young, healthy woman with a small abscess in the right superior colliculus.
Article
Multidisciplinary Sciences
Icnelia Huerta-Ocampo, Daniel Dautan, Nadine K. Gut, Bakhtawer Khan, Juan Mena-Segovia
Summary: The study reveals that cholinergic neurons in the midbrain receive inputs from various areas across the whole brain, segregated into specific functional domains. Motor-related areas preferentially target the PPN, while limbic-related areas preferentially target the LDT. PPN cholinergic neurons receive preferential inputs from basal ganglia structures, whereas LDT cholinergic neurons receive preferential inputs from limbic cortical areas.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Yarmo Mackenbach, J. Gerard G. Borst
Summary: The medial superior olive (MSO) is a specialized binaural nucleus that detects the relative arrival times of sounds at both ears. Excitatory inputs to MSO neurons from different ears are segregated to different dendrites, and the neurons can phase-lock to multiple tones within a stimulus. The ability to phase-lock is linearly related to the size of the subthreshold response.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Alexander R. Callan, Martin Hess, Felix Felmy, Christian Leibold
Summary: Researchers have found that neurons in the medial superior olive (MSO) have highly integrated synaptic inputs on their dendrites, enabling secure transmission through coordinated release of neurotransmitters at multiple independent active zones. The anatomical arrangement increases the amplitude and sharpens the time course of excitatory postsynaptic potentials, leading to improved binaural coincidence detection compared with single large synapses at the soma.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Louise R. Brace, Igor Kraev, Claire L. Rostron, Michael G. Stewart, Paul G. Overton, Eleanor J. Dommett
Article
Neurosciences
L. R. Brace, I. Kraev, C. L. Rostron, M. G. Stewart, P. G. Overton, E. J. Dommett
Article
Clinical Neurology
Sam Harris, Luke Boorman, Michael Bruyns-Haylett, Aneurin Kennerley, Hongtao Ma, Mingrui Zhao, Paul G. Overton, Theodore H. Schwartz, Jason Berwick
Article
Endocrinology & Metabolism
Sam Harris, Michael Bruyns-Haylett, Aneurin Kennerley, Luke Boorman, Paul G. Overton, Hongtao Ma, Mingrui Zhao, Theodore H. Schwartz, Jason Berwick
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2013)
Article
Neurosciences
C. Bertram, L. Dahan, L. W. Boorman, S. Harris, N. Vautrelle, M. Leriche, P. Redgrave, P. G. Overton
JOURNAL OF NEUROPHYSIOLOGY
(2014)
Article
Neurosciences
Sam Harris, Hongtao Ma, Mingrui Zhao, Luke Boorman, Ying Zheng, Aneurin Kennerley, Michael Bruyns-Haylett, Paul G. Overton, Jason Berwick, Theodore H. Schwartz
Article
Neurosciences
M. Rolland, C. Carcenac, P. G. Overton, M. Savasta, V. Coizet
Review
Neurosciences
P. G. Overton, N. Vautrelle, P. Redgrave
Article
Neurosciences
K. M. Clements, I. M. Devonshire, J. N. J. Reynolds, P. G. Overton
Article
Public, Environmental & Occupational Health
Jack K. Garlovsky, Jane Simpson, Richard A. Grunewald, Paul G. Overton
PSYCHOLOGY & HEALTH
(2016)
Review
Psychology, Clinical
Jack K. Garlovsky, Paul G. Overton, Jane Simpson
JOURNAL OF CLINICAL PSYCHOLOGY
(2016)
Article
Psychology, Clinical
Philip A. Powell, Haffiezhah A. Azlan, Jane Simpson, Paul G. Overton
JOURNAL OF BEHAVIORAL MEDICINE
(2016)
Article
Psychology, Clinical
Philip A. Powell, Paul G. Overton, Jane Simpson
JOURNAL OF CLINICAL PSYCHOLOGY
(2014)
Article
Psychology, Experimental
Philip A. Powell, Jane Simpson, Paul G. Overton
COGNITION & EMOTION
(2013)
Article
Psychology, Clinical
Philip A. Powell, Jane Simpson, Paul G. Overton