期刊
FRONTIERS IN NEUROANATOMY
卷 6, 期 -, 页码 1-12出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnana.2012.00028
关键词
cortex; cortical areas; cytoarchitecture; evolutionary development; gradient; neurogenesis; primate evolution
资金
- National Science Foundation/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [910149/96-99]
- NSF [IBN-0138113, CCF-0835706]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development fellowship [F32HD067011]
- G. Harold and Leila Y. Mathers Foundation
- National University of Ireland
- New World Monkey
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0849612] Funding Source: National Science Foundation
The cellular and areal organization of the cerebral cortex impacts how it processes and integrates information. How that organization emerges and how best to characterize it has been debated for over a century. Here we demonstrate and describe in the isocortices of seven primate species a pronounced anterior-to-posterior gradient in the density of neurons and in the number of neurons under a unit area of the cortical surface. Our finding assert that the cellular architecture of the primate isocortex is neither arranged uniformly nor into discrete patches with an arbitrary spatial arrangement. Rather, it exhibits striking systematic variation. We conjecture that these gradients, which establish the basic landscape that richer areal and cellular structure is built upon, result from developmental patterns of cortical neurogenesis: that the gradient in neurons per unit of cortical area fosters the integration and dimensional reduction of information along its ascent through sensory areas and toward frontal cortex.
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