Article
Neurosciences
Kseniia Prokofeva, Yuki C. Saito, Yasutaka Niwa, Seiya Mizuno, Satoru Takahashi, Arisa Hirano, Takeshi Sakurai
Summary: To understand the regulation of sleep-wakefulness cycles, it is important to study the relationship between the preoptic area (POA) and lateral hypothalamic area (LHA), which have opposing roles in sleep-wakefulness regulation. This study revealed the direct connection between GABA- and galanin-producing neurons in the ventrolateral preoptic nucleus (VLPO) and orexin-producing neurons in the LHA. It also discovered that the VLPOGABA-LHA pathway plays a previously unknown role in the regulation of sleep and wakefulness.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Sarah L. Reitz, Max B. Kelz
Summary: The hypothalamic preoptic area (POA) plays a crucial role in regulating arousal states in both natural and drug-induced forms of unconsciousness. While known for promoting sleep and wake, the complexity and molecular heterogeneity of the POA make it challenging to distinguish between different populations of neurons involved in these processes.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Kevin R. Coffey, Vaishnavi Venkat, Mark O. West, David J. Barker
Summary: Neurons in the lateral preoptic area show varied responses to different components of drug self-administration. The majority of these neurons signal the operant response with increases in spiking activity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Rebecca Rothhaas, Shinjae Chung
Summary: Sleep and body temperature are tightly interconnected in mammals, with the preoptic area of the hypothalamus playing a crucial role in regulating these behaviors. Recent research on sleep- and thermo-regulatory POA neurons has raised new questions about the overlap and pathways of these neurons and the role of signaling molecules in coordinating sleep and body temperature regulation.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Marcos Garcia-Juarez, Ailyn Luna-Hernandez, Sandra Tapia-Hernandez, Omar Montes-Narvaez, Raymundo Dominguez-Ordonez, Miriam B. Tecamachaltzi-Silvaran, James G. Pfaus, Oscar Gonzalez-Flores
Summary: This study investigated the effect of apelin-13 on different brain areas at varying doses, and found that it can induce lordosis behavior, with a more pronounced effect in the VMH of EB-primed rats, and only the 0.75 μg infusion of apelin in the POA induced significant lordosis at 120 and 240 min.
NEUROSCIENCE LETTERS
(2022)
Article
Biology
Shuyun Xiao, Valerie Michael, Richard Mooney
Summary: This study reveals that neurons suppressing vocalizations are activated by predator cues or inhibitory social contexts in mice. It also uncovers how the brain weighs factors promoting and suppressing vocal production, and how the activation of specific neurons influences the decision to vocalize in mice.
Article
Cell Biology
Shuo Yang, Yu Lin Tan, Xiaohua Wu, Jingjie Wang, Jingjing Sun, Anqi Liu, Linhua Gan, Bo Shen, Xiaocui Zhang, Yu Fu, Ju Huang
Summary: Enhanced appetite in response to low temperature serves as a behavioral thermoregulation mechanism, with AgRP neurons in the hypothalamus being activated by cold exposure. Neurons in the medial preoptic area (mPOA) make excitatory synapses onto AgRP neurons in the arcuate nucleus (ARC), modulating feeding behavior in cold-evoked conditions.
Article
Neurosciences
Giulia Miracca, Berta Anuncibay-Soto, Kyoko Tossell, Raquel Yustos, Alexei L. Vyssotski, Nicholas P. Franks, William Wisden
Summary: The lateral preoptic hypothalamus plays a crucial role in NREM and REM sleep induction and NREM sleep homeostasis. Surprisingly, calcium signals in the lateral preoptic hypothalamus were found to be highest during REM sleep. NMDA receptors in the lateral preoptic hypothalamus were identified as the main drivers of excitation. Deleting these NMDA receptors led to insomnia and fragmented sleep patterns. The sleep fragmentation was specifically attributed to NMDA receptors on GABA neurons in the lateral preoptic hypothalamus.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Elda Arrigoni, Patrick M. Fuller
Summary: The article reviews the history of the preoptic area, focusing on the role of the ventrolateral preoptic nucleus (VLPO) in sleep-wake control. It also attempts to synthesize the current understanding of the circuit, cellular, and synaptic bases of the VLPO.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Andrey Kostin, Md Aftab Alam, Anton Saevskiy, Dennis McGinty, Md Noor Alam
Summary: This study investigates the specific contribution of certain neurons in sleep regulation and finds that they play a critical role in suppressing wake-active neurons and promoting sleep.
Article
Biochemistry & Molecular Biology
Andrey Kostin, Md. Aftab Alam, Anton Saevskiy, Chenyi Yang, Peyman Golshani, Md. Noor Alam
Summary: This study used calcium imaging to characterize the activity dynamics of ventrolateral preoptic area (VLPO) neurons and found that they play an important role in spontaneous sleep-waking and homeostatic sleep regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Jun Jiang, Guangyuan Zou, Jiayi Liu, Shuqin Zhou, Jing Xu, Hongqiang Sun, Qihong Zou, Jia-Hong Gao
Summary: Animal experiments demonstrate the crucial role of the hypothalamus in regulating sleep-wake cycles, while neuroimaging studies suggest the presence of wake-promoting and sleep-promoting regions within the human hypothalamus. Functional network organization of the hypothalamus shifts between wakefulness and sleep, with different brain regions showing varying connectivity patterns.
HUMAN BRAIN MAPPING
(2021)
Article
Multidisciplinary Sciences
Lindsay A. Pickett, Jonathan W. VanRyzin, Ashley E. Marquardt, Margaret M. McCarthy
Summary: The SDN-POA is a sexually dimorphic brain structure that is larger in males and is associated with mating preference. Microglia play a crucial role in reducing the size of the SDN in females by engulfing more neurons. Inhibiting microglia phagocytosis increases the SDN volume in females and affects their preference for male odors in adulthood.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Joel D. Hahn, Lei Gao, Tyler Boesen, Lin Gou, Houri Hintiryan, Hong-Wei Dong
Summary: This study investigated the neuronal connections of the lateral preoptic area (LPO) and the caudally adjacent lateral hypothalamic area anterior region (LHAa) in mice. The results showed highly diverse connections of these hypothalamic regions with over 200 gray matter regions spanning the forebrain, midbrain, and rhombicbrain. These connections are associated with various functions including reward prediction, innate survival behaviors, and affect.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Physiology
Nicolas M. Diaz, Shannon A. Gordon, Richard A. Lang, Ethan D. Buhr
Summary: Mammals regulate their body temperature by utilizing internal circadian clocks and thermosensitivity. The preoptic area of the hypothalamus houses temperature-sensitive circadian clocks that are influenced by temperature changes but not by light cues.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Ruth Morona, Jesus M. Lopez, R. Glenn Northcutt, Agustin Gonzalez
JOURNAL OF COMPARATIVE NEUROLOGY
(2018)
Article
Anatomy & Morphology
Nerea Moreno, Jesus M. Lopez, Ruth Morona, Daniel Lozano, Sara Jimenez, Agustin Gonzalez
FRONTIERS IN NEUROANATOMY
(2018)
Article
Neurosciences
Jesus M. Lopez, Daniel Lozano, Ruth Morona, Agustin Gonzalez
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Neurosciences
Jesus M. Lopez, Ruth Morona, Agustin Gonzalez
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Neurosciences
Jesus M. Lopez, Ruth Morona, Nerea Moreno, Daniel Lozano, Sara Jimenez, Agustin Gonzalez
JOURNAL OF COMPARATIVE NEUROLOGY
(2020)
Article
Neurosciences
Ruth Morona, Sandra Bandin, Jesus M. Lopez, Nerea Moreno, Agustin Gonzalez
JOURNAL OF COMPARATIVE NEUROLOGY
(2020)
Article
Anatomy & Morphology
Sara Jimenez, Jesus M. Lopez, Daniel Lozano, Ruth Morona, Agustin Gonzalez, Nerea Moreno
BRAIN STRUCTURE & FUNCTION
(2020)
Article
Agriculture, Dairy & Animal Science
Maria Jose Ruiz-Fernandez, Sara Jimenez, Encarnacion Fernandez-Valle, M. Isabel Garcia-Real, David Castejon, Nerea Moreno, Maria Ardiaca, Andres Montesinos, Salvador Ariza, Juncal Gonzalez-Soriano
Article
Neurosciences
Jesus M. Lopez, Sara Jimenez, Ruth Morona, Daniel Lozano, Nerea Moreno
Summary: The distribution patterns of a set of conserved brain developmental regulatory transcription factors were analyzed in the forebrain of the basal actinopterygian fish Acipenser ruthenus, consistent with the prosomeric model. In the telencephalon, the pallium was characterized by ventricular expression of Pax6. In the subpallium, the combined expression of Nkx2.1/Islet-1 (Isl1) allowed to propose ventral and dorsal areas.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Editorial Material
Behavioral Sciences
Oscar Marin, Nerea Moreno
BRAIN BEHAVIOR AND EVOLUTION
(2022)
Article
Behavioral Sciences
Sara Jimenez, Nerea Moreno
Summary: Cajal-Retzius cells in anurans show similarities with those in mammals, with the presence of comparable progenitor domains that contribute to cortical regional specification and territory-specific properties. This suggests a fundamental arrangement of pallial derivatives in vertebrates, even in species without a complex stratified cortical structure like the mammalian cerebral cortex.
BRAIN BEHAVIOR AND EVOLUTION
(2022)
Article
Agriculture, Dairy & Animal Science
Lidia Blazquez-Llorca, Lubna Morales de Paz, Rosario Martin-Orti, Inmaculada Santos-Alvarez, Maria E. Fernandez-Valle, David Castejon, Maria I. Garcia-Real, Raquel Salguero-Fernandez, Pilar Perez-Lloret, Nerea Moreno, Sara Jimenez, Maria J. Herrero-Fernandez, Juncal Gonzalez-Soriano
Summary: Anatomy is crucial in medical and veterinary education, but neuroanatomy poses particular challenges. A new teaching tool has been developed using 3D reconstructions of magnetic resonance images to aid in the understanding of clinical neurology and practice. This tool combines neuroanatomy and neuropathology, providing valuable insights for anatomists and clinicians.
Article
Anatomy & Morphology
Daniel Lozano, Jesus M. Lopez, Sara Jimenez, Ruth Morona, Victor Ruiz, Ana Martinez, Nerea Moreno
Summary: This study analyzed the expression patterns of SATB1 and SATB2 in the brain of different bony fish models, revealing significant differences in their distribution between different fish species, which may be related to the acquisition of different neural phenotypes.
BRAIN STRUCTURE & FUNCTION
(2023)