Article
Clinical Neurology
Loredana Storelli, Elisabetta Pagani, Alessandro Meani, Paolo Preziosa, Massimo Filippi, Maria A. Rocca
Summary: The study suggests that advanced diffusion-weighted imaging techniques can accurately detect white matter atrophy in patients with multiple sclerosis, providing more specific information than traditional methods that only measure volume and diffusion. Additionally, measures such as voxel-wise fiber-bundle cross-section and intra-cellular volume obtained at baseline are better predictors of clinical disability and cognitive impairment.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Massimo Filippi, Paolo Preziosa, Douglas L. Arnold, Frederik Barkhof, Daniel M. Harrison, Pietro Maggi, Caterina Mainero, Xavier Montalban, Elia Sechi, Brian G. Weinshenker, Maria A. Rocca
Summary: The use of MRI in the diagnosis of MS has evolved considerably, with the introduction of the 2017 McDonald criteria and new MRI markers. Artificial intelligence tools may complement human assessment in improving diagnosis and patient classification.
JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Konstantin Huhn, Peter Linz, Franziska Pemsel, Bernhard Michalke, Stefan Seyferth, Christoph Kopp, Mohammad Anwar Chaudri, Veit Rothhammer, Arnd Doerfler, Michael Uder, Armin M. Nagel, Dominik N. Mueller, Anne Waschbisch, De-Hyung Lee, Tobias Baeuerle, Ralf A. Linker, Stefanie Haase
Summary: Novel MRI techniques reveal the skin as a significant compartment of sodium storage in health and disease, with potential links to MS immunopathology. Increased sodium content in skin, as detected by Na-23-MRI, may predict future disease activity in male patients with RRMS. The skin's role as a storage compartment for sodium and its potential implications in autoimmune neuroinflammation, such as in MS, warrant further investigation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Clinical Neurology
Christopher Hollen, Lee E. Neilson, Ramon F. Barajas, Ian Greenhouse, Rebecca I. Spain
Summary: Conventional MRI is important for evaluating patients with multiple sclerosis, but its role in detecting the underlying pathophysiology of neurodegeneration is limited. Biomarkers that identify processes underlying neurodegeneration before irreversible damage occurs are needed. Oxidative stress is believed to play a major role in the pathogenesis of multiple neurodegenerative diseases, including multiple sclerosis. Non-invasive imaging techniques offer real-time assessment of oxidative stress within the brain, which is an area of unrealized potential.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Kelly A. Clark, Abby R. Manning, Luyun Chen, Fang Liu, Quy Cao, Amit Bar-Or, Russell T. Shinohara, Elizabeth Sweeney, Matthew K. Schindler
Summary: This study aimed to identify early MRI features of new multiple sclerosis (MS) lesions that would develop into paramagnetic rim lesions (PRLs) associated with progressive tissue injury in MS. Contrast-enhancing lesions in MS patients were imaged at 7 T within 4 weeks of observation and 3 and 6 months later. The study found that certain characteristics of early lesions were predictive of subsequent PRL status.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Mikkel K. E. Nygaard, Martin Langeskov-Christensen, Ulrik Dalgas, Simon F. Eskildsen
Summary: The study found that cortical diffusion and thalamic volume are closely associated with walking and cognitive performance in patients with relapsing-remitting multiple sclerosis (RRMS), and are highly affected by the presence of white matter lesions.
JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiali Shao, Xuewei Zhang, Wenrui Xu, Zhe Zhang, Jieying Zhang, Hua Guo, Tao Jiang, Weihong Zhang
Summary: The study found that NODDI has good reliability in evaluating epileptogenic tubers in TSC patients. ICVF showed advantages in detecting subtle epileptogenic tubers, and NODDI parameters have the potential to identify epileptogenicity.
EUROPEAN RADIOLOGY
(2021)
Article
Clinical Neurology
Sara Collorone, Ferran Prados, Baris Kanber, Niamh M. Cawley, Carmen Tur, Francesco Grussu, Bhavana S. Solanky, Marios Yiannakas, Indran Davagnanam, Claudia A. M. Gandini Wheeler-Kingshott, Frederik Barkhof, Olga Ciccarelli, Ahmed T. Toosy
Summary: Through the use of multi-parametric quantitative MRI, early multiple sclerosis patients were found to have alterations in neurite orientation dispersion and total sodium concentration in normal brain tissues, which may be related to the disease pathophysiology. Differences in neurite density, orientation dispersion, and total sodium concentration were observed in white and grey matter regions between patients and healthy controls, suggesting clinically relevant pathology.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dan Luo, Yuling Peng, Qiyuan Zhu, Qiao Zheng, Qi Luo, Yongliang Han, Xiaoya Chen, Yongmei Li
Summary: This study evaluated the diffusion kurtosis and susceptibility change in the U-fiber region of pwRRMS patients and found correlations with cognitive status and degeneration. The findings provide insights into cognitive impairment and brain atrophy in multiple sclerosis.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Tomoko Maekawa, Akifumi Hagiwara, Kazumasa Yokoyama, Masaaki Hori, Christina Andica, Shohei Fujita, Koji Kamagata, Akihiko Wada, Osamu Abe, Yuji Tomizawa, Nobutaka Hattori, Shigeki Aoki
Summary: The study hypothesized that myelin is more vulnerable to damage over time than axons in multiple sclerosis (MS) plaques. By analyzing quantitative MRI metrics, including myelin volume fraction (MVF) and g-ratio, the results indicated that longer duration from onset of MS plaques was associated with lower MVF and higher g-ratio, suggesting continuous damage to myelin in plaques. Myelin imaging using SyMRI and NODDI could be valuable for evaluating temporal changes in MS plaques.
Review
Clinical Neurology
Fabio Giuseppe Masuccio, Giulia Gamberini, Massimiliano Calabrese, Claudio Solaro
Summary: The study reveals a link between brain pathology and depressive symptoms in patients with multiple sclerosis, supporting the hypothesis that structural and functional brain impairment might substantially contribute to the development of depression in these patients. This suggests that depression in multiple sclerosis patients may have a neuro-biological basis and is not merely a consequence of neurological impairment.
NEUROLOGICAL SCIENCES
(2021)
Review
Clinical Neurology
Jacopo Pasquini, Michael J. Firbank, Roberto Ceravolo, Vincenzo Silani, Nicola Pavese
Summary: This review summarizes the literature on the application of diffusion magnetic resonance imaging (dMRI) in multiple system atrophy (MSA), focusing on microstructural abnormalities, diagnostic applications, and pathophysiological correlates. The studies included in this review identified widespread microstructural abnormalities in white matter, especially in specific brain regions. Gray matter degeneration and its involvement in subcortical structures were also observed. Diagnostic applications of dMRI, particularly for differentiating MSA parkinsonism from Parkinson's disease, showed promising results with high diagnostic accuracy using machine learning algorithms. Additionally, some studies explored the clinical correlates of microstructural abnormalities, highlighting links with motor, ocular, and cognitive impairments. However, the correct diagnosis of MSA in the early stages and further investigation of the pathophysiological mechanisms underlying microstructural abnormalities are still challenging.
MOVEMENT DISORDERS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jerome Hodel, Meike W. Vernooij, Mona K. Beyer, Mariasavina Severino, Xavier Leclerc, Alain Creange, Abir Wahab, Neesmah Badat, Sarah Toledano, Luc van den Hauwe, Ana Ramos, Antonella Castellano, Alexandre Krainik, Tarek Yousry, Alex Rovira
Summary: This study evaluated compliance with recommendations in imaging for multiple sclerosis (MS). The results showed that while MS imaging practices are relatively consistent across Europe, there is still partial adherence to recommendations.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Isabelle Riederer, Mark Muehlau, Claus Zimmer, Magaly Gutbrod-Fernandez, Nico Sollmann, Jan S. Kirschke
Summary: The study found that pre-contrast T1-w imaging does not significantly increase diagnostic confidence or detection rate of contrast-enhancing lesions in spinal cord MRI follow-up exams for patients with multiple sclerosis (MS).
EUROPEAN RADIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ido Ben-Shalom, Arnon Karni, Hadar Kolb
Summary: The introduction of new disease-modifying therapies in multiple sclerosis (MS) has significantly improved the quality of life for patients, but reducing long-term disability remains a challenge. Standard MRI lacks the ability to explore the underlying molecular-based processes, making it difficult to investigate silent disease progression. Novel modalities utilizing molecular imaging biomarkers have the potential to bridge this gap and become the first valid biomarkers for neuroprotection and remyelination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Marc E. Wolf, Beate Luz, Ludwig Niehaus, Pervinder Bhogal, Hansjoerg Baezner, Hans Henkes
Summary: The study focused on clinical manifestations and management of patients with cranial venous sinus thrombosis following exposure to the COVID-19 vaccine AstraZeneca, showing that these patients shared similarities in diagnosis and treatment processes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Joachim Runge, Luisa Cassini Ascencao, Christian Blahak, Thomas M. Kinfe, Christoph Schrader, Marc E. Wolf, Assel Saryyeva, Joachim K. Krauss
Summary: Deep brain stimulation surgery in patients on chronic antiplatelet or anticoagulation treatment is feasible with no increased risk of hemorrhage in the first year of follow-up. Appropriate patient selection and standardized perioperative management are necessary to reduce the risk of intracranial hemorrhage and thromboembolic complications.
ACTA NEUROCHIRURGICA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Claudia E. Weber, Julia Kramer, Matthias Wittayer, Johannes Gregori, Sigurd Randoll, Florian Weiler, Stefan Heldmann, Christina Rossmanith, Michael Platten, Achim Gass, Philipp Eisele
Summary: In patients with relapsing MS, the presence of IRLs was associated with more aggressive MRI disease characteristics both in terms of cross-sectional and longitudinal analyses. The study found that patients with IRLs had higher EDSS scores, lesion loads, and brain atrophy rates compared to those without IRLs.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Paola Valsasina, Claudio Gobbi, Chiara Zecca, Alex Rovira, Jaume Sastre-Garriga, Hugh Kearney, Marios Yiannakas, Lucy Matthews, Jacqueline Palace, Antonio Gallo, Alvino Bisecco, Achim Gass, Philipp Eisele, Massimo Filippi, Maria A. Rocca
Summary: This study evaluated the voxel-wise distribution and 1-year changes of cervical cord atrophy in a multicentre MS cohort, showing baseline and 1-year volume changes in different MS phenotypes. The results highlighted the correlation between baseline cord atrophy and disability, providing insights into spinal cord neurodegeneration over time in MS.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Claudia E. Weber, Matthias Wittayer, Matthias Kraemer, Andreas Dabringhaus, Kathrin Bail, Michael Platten, Lucas Schirmer, Achim Gass, Philipp Eisele
Summary: This study investigates the long-term dynamics of iron rim lesions (IRLs) in multiple sclerosis (MS) patients and finds that persistent IRLs tend to enlarge while non-IRLs tend to shrink over time. Moreover, IRLs are associated with sustained tissue damage.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Matthias Reichl, Matthias Wittayer, Claudia E. Weber, Michael Platten, Achim Gass, Philipp Eisele
Summary: The study found that the central vein sign (CVS) is consistent in chronic multiple sclerosis (MS) lesions, suggesting that CVS could be a reliable imaging marker to increase the specificity of MRI in MS.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Nicolas Wenzel, Matthias Wittayer, Claudia E. Weber, Lucas Schirmer, Michael Platten, Achim Gass, Philipp Eisele
Summary: This study identified that acute contrast-enhancing lesions in MS patients with a ring-like contrast-enhancement pattern and a peripheral hypointense rim on ADC maps have a higher likelihood of converting into iron rim lesions. This combination of imaging parameters can be used to predict lesion evolution and could be a target for early therapeutic intervention.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Philipp Eisele, Matthias Wittayer, Claudia E. Weber, Michael Platten, Lucas Schirmer, Achim Gass
Summary: This study investigated the impact of disease-modifying therapies (DMTs) on tissue damage in iron rim lesions in patients with multiple sclerosis. The results showed that DMTs had a beneficial delayed effect on lesion evolution and tissue matrix damage.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Matthias Wittayer, Claudia E. Weber, Michael Platten, Lucas Schirmer, Achim Gass, Philipp Eisele
Summary: In multiple sclerosis, iron rim lesions on magnetic resonance imaging are associated with higher disability scores. However, the increased disability cannot be solely explained by the topography or the disruption of neural networks caused by these lesions.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Immunology
Sarah Kehr, Philipp Berg, Susanne Muller, Sarah A. Fiedler, Britta Meyer, Gabriele Ruppert-Seipp, Cornelia Witzenhausen, Marc E. Wolf, Hans H. Henkes, Doris Oberle, Brigitte Keller-Stanislawski, Markus B. Funk
Summary: This study presents the long-term outcomes of 44 patients who developed cerebral venous sinus thrombosis after receiving the AdChOx1 nCoV-19 COVID-19 vaccine. The assessment showed a range of outcomes, from good recovery to severe disability or death.
Article
Clinical Neurology
Joachim Runge, Johanna M. Nagel, Luisa Cassini Ascencao, Christian Blahak, Thomas M. Kinfe, Christoph Schrader, Marc E. Wolf, Assel Saryyeva, Joachim K. Krauss
Summary: This study investigated the impact of a transventricular trajectory compared to a transcerebral approach on the occurrence of symptomatic and asymptomatic hemorrhage after deep brain stimulation (DBS) electrode placement. The results showed that transventricular approaches can be safely performed when precautions like using a guiding cannula are applied.
OPERATIVE NEUROSURGERY
(2022)
Article
Genetics & Heredity
Joohyun Park, Arianna Tucci, Valentina Cipriani, German Demidov, Clarissa Rocca, Jan Senderek, Michaela Butryn, Ana Velic, Tanya Lam, Evangelia Galanaki, Elisa Cali, Letizia Vestito, Reza Maroofian, Natalie Deininger, Maren Rautenberg, Jakob Admard, Gesa-Astrid Hahn, Claudius Bartels, Nienke J. H. van Os, Rita Horvath, Patrick F. Chinnery, May Yung Tiet, Channa Hewamadduma, Marios Hadjivassiliou, George K. Tofaris, Nicholas W. Wood, Stefanie N. Hayer, Friedemann Bender, Benita Menden, Isabell Cordts, Katrin Klein, Huu Phuc Nguyen, Joachim K. Krauss, Christian Blahak, Tim M. Strom, Marc Sturm, Bart van de Warrenburg, Holger Lerche, Boris Macek, Matthis Synofzik, Stephan Ossowski, Dagmar Timmann, Marc E. Wolf, Damian Smedley, Olaf Riess, Ludger Schoels, Henry Houlden, Tobias B. Haack, Holger Hengel
Summary: This study investigated heterozygous variants in the UCHL1 gene and identified a novel disease mechanism associated with ataxia. Through gene-burden analyses and proteomics, it was found that haploinsufficiency of UCHL1 can cause neurodegenerative disorders.
GENETICS IN MEDICINE
(2022)
Article
Clinical Neurology
Nicolas Wenzel, Matthias Wittayer, Claudia E. Weber, Michael Platten, Achim Gass, Philipp Eisele
Summary: This study investigated tissue integrity in the spinal cord and brain of multiple sclerosis (MS) patients using the T1/T2-weighted ratio. It found that patients with iron rim lesions (IRLs) had higher disability scores and smaller cross-sectional area of the upper cervical cord, while their T1/T2w values were significantly lower compared to non-IRLs. Furthermore, T1/T2w values of lesions were lower compared to normal-appearing white and gray matter in both the brain and spinal cord. The study suggests that IRLs can serve as an imaging marker of disease severity and the T1/T2w ratio maps can provide insights into the pathophysiological processes of MS.
JOURNAL OF NEUROIMAGING
(2023)
Article
Clinical Neurology
Matthias Wittayer, Claudia E. Weber, Maximilian Kittel, Michael Platten, Lucas Schirmer, Hayrettin Tumani, Achim Gass, Philipp Eisele
Summary: In patients with multiple sclerosis, iron rim lesions (IRLs) are associated with tissue damage, disease severity, and chronic active inflammation behind the blood-brain barrier. This study investigates CSF markers of intrathecal inflammation in patients with IRLs compared to patients without IRLs, as well as tissue damage in lesions and normal-appearing white matter (NAWM) near CSF spaces.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Ann-Kathrin Nold, Matthias Wittayer, Claudia E. Weber, Michael Platten, Achim Gass, Philipp Eisele
Summary: This study aimed to investigate the short-term dynamics of brain atrophy development after initiation of disease-modifying therapy (DMT) in a real-world setting. The study found that the highest brain volume changes were observed in the first 12 months after initiation of natalizumab treatment.
JOURNAL OF NEUROIMAGING
(2023)
