Article
Nutrition & Dietetics
Matthew J. Granger, Peter K. Eck, Itzel Vazquez-Vidal, Maryam Shamloo, James D. House, Dylan S. Mackay
Summary: The GenePredict Plant Sterol study aimed to validate the associations of LDL cholesterol lowering with specific APOE and CYP7A1 genosets through a priori recruitment, but the recruitment target could not be reached. Despite the shortfall, reductions in LDL cholesterol were similar across all genosets, indicating that the trial's objective may still have been met. In conclusion, APOE and CYP7A1 genotypes did not influence the effectiveness of LDL cholesterol reductions through dietary intervention with plant sterols, and it is challenging to obtain adequate numbers of participants in trials using genoset-based recruitment.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Changge Guan, Shun Iwatani, Xin-hui Xing, Naoyuki Yamamoto
Summary: Researchers isolated various peptides with inhibitory activity against human dipeptidyl peptidase-IV (hDPP-IV) from synthetic tripeptide mixtures, finding that VPV, VPI, and IPI showed the highest hDPP-IV inhibitory activity. Analysis of dissociation constants and IC(50) values provided insight into the reasons for the potent inhibitory activity of these tripeptides, with peptides having lower Ki and IC(50) values showing slower degradation when incubated with hDPP-IV.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2021)
Article
Chemistry, Analytical
Nadia Mabel Perez-Vielma, Modesto Gomez-Lopez, Jesus Maldonado, Jose Correa-Basurto, Maria de los angeles Martinez-Godinez, Angel Miliar-Garcia
Summary: Bioactive peptides play a crucial role in regulating various physiological functions, such as oxidative stress and hypertension. This study investigates the interaction between the milk-derived peptide VPP and the genes SOD and CAT in obese children using a QCM-D biosensor and molecular docking. Both experimental and simulation results show that VPP interacts with the minimal promoter regions of CAT and SOD genes, providing insights into the interaction of small peptides with specific gene sequences.
ANALYTICAL METHODS
(2023)
Article
Multidisciplinary Sciences
Ewelina Wozniak, Marlena Broncel, Mateusz Niedzielski, Agnieszka Wozniak, Paulina Gorzelak-Pabis
Summary: The study compared the pleiotropic effects of two commonly-used statins (atorvastatin, rosuvastatin), ezetimibe, and their combinations, on the mRNA expression of pro-inflammatory and anti-inflammatory genes in endothelial cells damaged by 25-OHC. The results showed that rosuvastatin had the strongest anti-inflammatory effects and was most effective at reducing the effect of oxysterols. Both statins had stronger anti-inflammatory effects compared to ezetimibe. The combination therapies' anti-inflammatory effects seemed to be based on the statins alone, rather than their combination with ezetimibe.
Article
Biochemistry & Molecular Biology
Zi-Chun Wang, Yu-Xi Ling, Ya-Xin Liang, Zi-Qi Li, Jie Dai, Di-Feng Ren
Summary: The walnut meal is a by-product of walnut oil pressing, which contains a large amount of protein and active compounds. Peptides identified from walnut meal, such as YVPHW and LAPF, showed a strong inhibitory effect on acetylcholinesterase.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2023)
Article
Nutrition & Dietetics
Reetta Holma, Reijo Laatikainen, Helena Orell, Heikki Joensuu, Katri Peuhkuri, Tuija Poussa, Riitta Korpela, Pia Osterlund
Article
Multidisciplinary Sciences
Stefania Noerman, Anton Klavus, Elina Jarvela-Reijonen, Leila Karhunen, Seppo Auriola, Riitta Korpela, Raimo Lappalainen, Urho M. Kujala, Sampsa Puttonen, Marjukka Kolehmainen, Kati Hanhineva
SCIENTIFIC REPORTS
(2020)
Review
Pharmacology & Pharmacy
Hanne Salmenkari, Riitta Korpela, Heikki Vapaatalo
Summary: Inflammatory bowel diseases require new treatment options to control inflammation and fibrosis, and RAS inhibitors may be a cost-effective and effective alternative. While animal studies have shown the efficacy of RAS inhibitors in colitis, human data are still limited. Retrospective studies indicate that IBD patients using RAS inhibitors have a milder disease course and fewer hospitalizations.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Elina Jarvela-Reijonen, Suvi Jarvinen, Leila Karhunen, Tiina Fohr, Tero Myllymaki, Essi Sairanen, Sanni Lindroos, Katri Peuhkuri, Maarit Hallikainen, Jussi Pihlajamaki, Sampsa Puttonen, Riitta Korpela, Miikka Ermes, Raimo Lappalainen, Urho M. Kujala, Marjukka Kolehmainen, Jaana Laitinen
Summary: The study found that better nocturnal recovery was associated with better diet quality, lower alcohol consumption, and possibly less intuitive eating.
JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tuulia Onali, Anne Kivimaki, Matti Mauramo, Tuula Salo, Riitta Korpela
Summary: Wild berries such as lingonberry and bilberry are rich in phytochemicals and demonstrate anticancer effects on digestive tract cancers. Studies indicate that these berries inhibit tumor formation and cancer cell growth in colorectal cancer, supporting their potential as antiproliferative and antitumor agents.
Article
Medicine, Research & Experimental
Zan Pang, Hanna Launonen, Riitta Korpela, Heikki Vapaatalo
Summary: This study found that low sodium diet, dibutyryl-cAMP and Ang II can stimulate the local synthesis of aldosterone in the large intestine, similar to the adrenal glands.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Hanna Launonen, Lotta Luiskari, Jere Linden, Aino Siltari, Hanne Salmenkari, Riitta Korpela, Heikki Vapaatalo
Summary: In this study, we examined the effect of the aldosterone synthase inhibitor FAD286 on intestinal inflammation. Contrary to expectations, FAD286 did not inhibit intestinal aldosterone synthesis and even exacerbated the signs of inflammation, indicating its harmful effects.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Physiology
Z. Pang, R. Korpela, H. Vapaatalo
Summary: In this study, the presence of the complete aldosterone production process from precursor corticosterone to final product aldosterone was detected in the murine large intestine. The enzyme activity of CYP11B2, involved in aldosterone synthesis, was higher in the large intestine compared to the small intestine, and increased during the dark period in the ileum and colon. The highest concentration of aldosterone was detected in the large intestine during the dark period. Overall, this study highlights the widespread presence of CYP11B2 enzyme activity throughout the intestine, with higher aldosterone production occurring in the large intestine during the dark period, and no differences observed between early and late light hours.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2022)
Article
Physiology
H. Launonen, Z. Pang, J. Linden, A. Siltari, R. Korpela, H. Vapaatalo
Summary: Aldosterone, the main mineralocorticoid, is synthesized from cholesterol in the adrenal cortex and regulates sodium and potassium balance. Recent studies show that aldosterone can be locally produced in tissues other than the adrenal cortex, such as the brain, heart, blood vessels, kidneys, and adipocytes. The research suggests that aldosterone may also be synthesized in the intestine.
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Physiology
L. Varmavuori, H. Launonen, R. Korpela, H. Vapaatalo
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2020)
Article
Medicine, Research & Experimental
L-U Suojanen, A. J. Ahola, S. Kupila, R. Korpela, K. H. Pietilainen
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2020)
Article
Dentistry, Oral Surgery & Medicine
Qingru Jiang, Veera Kainulainen, Iva Stamatova, Sok-Ja Janket, Jukka H. Meurman, Riitta Korpela
Article
Psychology, Clinical
Elina Jarvela-Reijonen, Sampsa Puttonen, Leila Karhunen, Essi Sairanen, Jaana Laitinen, Mikko Kolehmainen, Jussi Pihlajamaki, Urho M. Kujala, Riitta Korpela, Miikka Ermes, Raimo Lappalainen, Marjukka Kolehmainen
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2020)
Article
Physiology
L. Pasanen, H. Launonen, A. Siltari, R. Korpela, H. Vapaatalo, H. Salmenkari, R. A. Forsgard
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2019)
Article
Nutrition & Dietetics
Reijo Laatikainen, Jonna Jalanka, Jussi Loponen, Sanna-Maria Hongisto, Markku Hillila, Jari Koskenpato, Riitta Korpela, Anne Salonen
Article
Biochemistry & Molecular Biology
Davide Risso, Gillian Dunngalvin, Sameer Saxena, Andrea Doolan, Lisa Spence, Kavita Karnik
Summary: This study investigated the gastrointestinal tolerance of low-calorie sugar D-allulose in young children and found that it was well tolerated. It can be considered as a candidate for replacing added sugars with lower caloric content in commercially produced goods.
Article
Biochemistry & Molecular Biology
Xinying Suo, Anna Baggio, Nicoletta Pellegrini, Silvia Vincenzetti, Elena Vittadini
Summary: This study investigated the effects of shape, gluten, and structural breakdown on the starch digestibility and glycemic index of gluten-containing and gluten-free pasta. The results showed that mastication effort, shape, and gluten content had significant impacts on starch digestion and glycemic index, with gluten being the major factor affecting the amount of digested starch.
Article
Biochemistry & Molecular Biology
Xinnuo Hu, Yanjun Yang, Cuihua Chang, Junhua Li, Yujie Su, Luping Gu
Summary: Fish collagen was enzymatically hydrolyzed using alkaline, papain, and ginger protease. The addition of ginger protease increased the degree of hydrolysis and resulted in changes in the amino acid composition and molecular weight distribution of the peptides. Combined hydrolysis with ginger protease improved the ACE inhibitory activity of the sample but affected fibroblast proliferation activity.
Article
Biochemistry & Molecular Biology
Tong Nie, Xin Wang, Aqun Li, Anshan Shan, Jun Ma
Summary: This study investigated the mechanism by which hesperidin prevents nonalcoholic fatty liver disease (NAFLD) by modulating fatty acid beta oxidation. The results suggest that hesperidin promotes fatty acid beta oxidation by activating SIRT1/PGC1 alpha, thus improving NAFLD.
Article
Biochemistry & Molecular Biology
Li Li, Jing Zhao, Jinxue Wang, Qianqian Xiong, Xuechun Lin, Xiaolei Guo, Fan Peng, Wangqun Liang, Xuezhi Zuo, Chenjiang Ying
Summary: The daily administration of 10 g d-1 inulin-type fructans significantly reduced the circulating arsenic retention in end-stage renal disease by increasing the arsenic clearance rate through urine and dialysis. However, it was found to be ineffective for other trace elements.
Article
Biochemistry & Molecular Biology
Chuanchuan Wang, Weixuan Chen, Yishan Jiang, Xiao Xiao, Qianhui Zou, Jiarui Liang, Yu Zhao, Qianxu Wang, Tian Yuan, Rui Guo, Xuebo Liu, Zhigang Liu
Summary: Autism Spectrum Disorder (ASD) symptoms may be improved through modulation of gut microbiota. This study investigated the effects of a synbiotic treatment on an ASD-like mouse model, and found that it rectified social impairments, attenuated inflammatory cytokine expressions, protected gut barrier integrity, and altered gut microbiota composition. The synbiotic treatment elevated beneficial metabolites and upregulated genes associated with their synthesis. Overall, the synbiotic combination mitigated ASD-related social impairments through regulation of the gut-brain axis.
Review
Biochemistry & Molecular Biology
Chunli Kong, Caiping Duan, Yixuan Zhang, Yiying Wang, Zheng Yan, Sumei Zhou
Summary: This review critically discusses the physicochemical properties of bioactive molecules in kidney beans and focuses on the current knowledge of non-starch polysaccharide (NSP) structure and function on intestinal health and metabolism. It also provides suggestions for further investigation and development of NSPs as novel plant carbohydrate resources.
Article
Biochemistry & Molecular Biology
Fei Shen, Qianqian Wang, Sami Ullah, Ya Pan, Minjie Zhao, Jing Wang, Ming Chen, Fengqin Feng, Hao Zhong
Summary: This study investigated the peristalsis-promoting potential of Ligilactobacillus acidipiscis YJ5 and its underlying molecular mechanism in relieving constipation. The results showed that L. acidipiscis YJ5 intervention increased intestinal peristalsis in zebrafish and mouse models, reduced colonic aquaporin expression, repaired intestinal morphological damage, enhanced the colonic mucosal barrier, and reversed the gut microbiota structure. The positive effects of L. acidipiscis YJ5 were attributed to its metabolites such as malic acid and heliangin.
Article
Biochemistry & Molecular Biology
Zhuo Qu, Jiahui Tian, Jiachen Sun, Ying Shi, Jianqiang Yu, Wannian Zhang, Chunlin Zhuang
Summary: Smoking is the main risk factor for lung cancer, but garlic oil compound DATS shows potential as a chemopreventive agent. DATS can inhibit the carcinogenic effects of tobacco and regulate gut microbiota, as well as activate the PPAR-gamma pathway to suppress tumor growth.
Article
Biochemistry & Molecular Biology
Yanli Zhang, Jielun Hu, Yadong Zhong, Shuai Liu, Liandi Liu, Xinyi Mu, Chunhua Chen, Shenji Yang, Guohao Li, Duoduo Zhang, Xinru Huang, Jinrui Yang, Xiaojun Huang, Shuigen Bian, Shaoping Nie
Summary: The study found that different ratios of insoluble and soluble dietary fiber have distinct effects on gut microbiota and serum metabolites. Increasing the ratio of insoluble dietary fiber increases the relative abundance and acid production of specific bacterial genera, while increasing the ratio of soluble dietary fiber increases the diversity and relative abundance of other bacterial genera and regulates metabolic pathways.
Article
Biochemistry & Molecular Biology
Enhui Tang, Tong Hu, Zhaokang Jiang, Xiaojun Shen, Huan Lin, Haiyan Xian, Xinlan Wu
Summary: Isoquercitrin alleviates lipopolysaccharide-induced intestinal mucosal barrier damage in mice by inhibiting the TLR4/MyD88/NF-kappa B signaling pathway and modulating the intestinal flora.
Article
Biochemistry & Molecular Biology
Nesma A. Abd Elrazik, Sahar A. Helmy
Summary: This study found that betanin, the major pigment in red beetroot, has a protective effect against bleomycin-induced pulmonary fibrosis in rats. The protective effect may be attributed to the attenuation of the NLRP3/IL-1 beta/TGF-beta 1 signaling pathway and the suppression of the EMT process.
Article
Biochemistry & Molecular Biology
Sha Li, Longchen Shang, Yuanyuan Chen, Rong Song, Jing Li, Bin Li
Summary: A new form of konjac fiber was prepared that could instantly expand in contact with digestive fluid, inhibiting the digestion of food. The digestion regulation ability of the fiber was influenced by the freezing temperature used during preparation, with the fiber prepared at -20 degrees C showing the best performance in delaying gastric emptying and preventing intestinal starch hydrolysis.
Article
Biochemistry & Molecular Biology
Xian Xia, Jiangdong Li, Rui Liang, Yi Li, Xiaojuan Ma, Ying Yang, Daniel Lozano-Ojalvo
Summary: This study aimed to reduce the allergenicity of ovomucoid through unfolding-assisted glycation. The results showed that maltose glycation effectively reduced the IgG-binding capacity of the allergen. Unfolded and glycated ovomucoid exhibited enhanced antioxidant activity and metal ion chelating ability.