期刊
DRUG DESIGN DEVELOPMENT AND THERAPY
卷 7, 期 -, 页码 127-129出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/DDDT.S41756
关键词
beta-blocker; epistaxis; children
资金
- Ministry of Science and Technology of the Republic of Serbia [175092]
We hypothesized that some characteristics of beta-blockers, including negative inotropic, peripheral vasoconstrictor, and antiangiogenic effects, might be potentially useful in treating children with epistaxis. From June 2010 to March 2012, a total of seven children with recurrent primary epistaxis resistant to conventional management were observed at our institution. An overall effectiveness of propranolol was noted in all seven children when given a dose of 1.5-2 mg/kg/day (divided into three doses) as a second line therapy for terminating epistaxis. Based on our first experience, we believe that propranolol could be a favorable treatment option for patients with primary epistaxis.
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