Targeting adipose tissue

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

(2012) Andrew J. Whittle et al.   CELL

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

NS-1: A novel partial peroxisome proliferator-activated receptor γ agonist to improve insulin sensitivity and metabolic profile

(2012) Sumit Chaudhary et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

(2012) Marica Bordicchia et al.   JOURNAL OF CLINICAL INVESTIGATION

Balaglitazone: A Second Generation Peroxisome Proliferator-Activated Receptor (PPAR) Gamma (γ) Agonist

(2012) R. Agrawal et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes

(2011) Joo-Young Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

From PDE3B to the regulation of energy homeostasis

(2011) Eva Degerman et al.   CURRENT OPINION IN PHARMACOLOGY

Glitazone-like action of glimepiride and glibenclamide in primary human adipocytes

(2011) P. Mayer et al.   DIABETES OBESITY & METABOLISM

Efficacy and safety of the PPARγ partial agonist balaglitazone compared with pioglitazone and placebo: a phase III, randomized, parallel-group study in patients with type 2 diabetes on stable insulin therapy

(2011) Kim Henriksen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Phosphodiesterase type 5 (PDE5) in the adipocyte: a novel player in fat metabolism?

(2011) Andrea Armani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Using brown adipose tissue to treat obesity – the central issue

(2011) Andrew J. Whittle et al.   TRENDS IN MOLECULAR MEDICINE

Exposure to Phosphodiesterase Type 5 Inhibitors Stimulates Aromatase Expression in Human Adipocytes in vitro

(2010) Antonio Aversa et al.   Journal of Sexual Medicine

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

(2010) Miguel López et al.   NATURE MEDICINE

Cellular bioenergetics as a target for obesity therapy

(2010) Yu-Hua Tseng et al.   NATURE REVIEWS DRUG DISCOVERY

Deletion of Inducible Nitric-Oxide Synthase in Leptin-Deficient Mice Improves Brown Adipose Tissue Function

(2010) Sara Becerril et al.   PLoS One

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

(2010) A. Vegiopoulos et al.   SCIENCE

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Cannabinoid type 1 receptor blockade induces transdifferentiation towards a brown fat phenotype in white adipocytes

(2009) N. Perwitz et al.   DIABETES OBESITY & METABOLISM

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue

(2009) Maria Cristina Zingaretti et al.   FASEB JOURNAL

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues

(2009) B. Xue et al.   MOLECULAR AND CELLULAR BIOLOGY

C/EBP  and the Corepressors CtBP1 and CtBP2 Regulate Repression of Select Visceral White Adipose Genes during Induction of the Brown Phenotype in White Adipocytes by Peroxisome Proliferator-Activated Receptor   Agonists

(2009) C. Vernochet et al.   MOLECULAR AND CELLULAR BIOLOGY

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

(2009) Shingo Kajimura et al.   NATURE

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protein Kinase G Controls Brown Fat Cell Differentiation and Mitochondrial Biogenesis

(2009) B. Haas et al.   Science Signaling

BAT: a new target for human obesity?

(2009) Gema Frühbeck et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor β subtype selective agonist KB-141

(2008) Galina Bryzgalova et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE

The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from β3-adrenoceptor agonists

(2008) Jonathan R. S. Arch   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

White Fat Progenitor Cells Reside in the Adipose Vasculature

(2008) W. Tang et al.   SCIENCE