Article
Medicine, General & Internal
Maria Pina Dore, Giuseppe Fanciulli, Alessandra Manca, Giovanni Mario Pes
Summary: This study investigated the relationship between thyroid diseases (TDs) and Helicobacter pylori infection. The results showed that long-lasting H. pylori infection was significantly associated with autoimmune thyroid diseases (AITD), but not with non-autoimmune TD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Ivani Novato Silva, Lara Vieira Marcal, Dulciene Maria Magalhaes Queiroz
Summary: Helicobacter pylori (H. pylori) infection is associated with autoimmune thyroid disease (ATD) in children, and the prevalence of infection in this study cohort was 19.44%. While there were no differences in thyroid hormone levels and antithyroid antibodies, the infection may lead to impairment in the thyroid hormonal balance.
FRONTIERS IN PEDIATRICS
(2022)
Review
Immunology
Li Wang, Zheng-Min Cao, Li-Li Zhang, Xin-can Dai, Zhen-ju Liu, Yi-xian Zeng, Xin-Ye Li, Qing-Juan Wu, Wen-liang Lv
Summary: Through nearly 40 years of research, it has been found that Helicobacter pylori is associated with the natural history of many upper gastrointestinal diseases and may be associated with other types of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Sebla Gunes, Jiangping Wu, Berk Ozyilmaz, Reyhan Deveci Sevim, Tolga Unuvar, Ahmet Anik
Summary: This study reports the association of EFNB1 mutation with T1DM and autoimmune thyroiditis in CFNS patients for the first time.
Review
Endocrinology & Metabolism
Om Saswat Sahoo, Rhiti Mitra, Arghyadeep Bhattacharjee, Samarjit Kar, Oindrilla Mukherjee
Summary: This review examines the consistency of reports on the role of Diabetes Mellitus in the pathogenesis of Helicobacter pylori (H. pylori). Recent studies have shown conflicting findings regarding the prevalence of H. pylori infections in patients with type 2 diabetes mellitus (T2DM). The review analyzes the possible relationship between H. pylori infections and T2DM and conducts a meta-analysis to quantify the association.
CURRENT DIABETES REPORTS
(2023)
Article
Gastroenterology & Hepatology
Massimo Rugge, Ludovica Bricca, Stefano Guzzinati, Diana Sacchi, Marco Pizzi, Edoardo Savarino, Fabio Farinati, Manuel Zorzi, Matteo Fassan, Angelo Paolo Dei Tos, Peter Malfertheiner, Robert M. Genta, David Y. Graham
Summary: The study found that autoimmune gastritis (AIG) patients exhibit oxyntic-predominant-mononuclear inflammation, PPM (more than IM), and ECL-cell hyperplasia/neoplasia as histological hallmarks. Over a cumulative follow-up time of 10,541 person years, there was no excess risk of gastric or other malignancies found, except for a (marginally significant) risk of thyroid cancer.
Article
Immunology
Fabiana Zingone, Valentina Pilotto, Romilda Cardin, Gemma Maddalo, Costanza Orlando, Matteo Fassan, Ilaria Marsilio, Eugenio Collesei, Filippo Pelizzaro, Fabio Farinati
Summary: This study analyzed the expression profile of selected miRNAs in patients with autoimmune atrophic gastritis, non-autoimmune multifocal atrophic gastritis, and healthy control subjects. The results showed that miR-21 was overexpressed in patients with gastric precancerous conditions, while miR-142 and miR-223 were underexpressed compared to healthy controls. Controlling miRNA expression could have significant implications for treating chronic autoimmune diseases and cancer progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Cheuk Wun Li, Roman Osman, Francesca Menconi, Larissa C. Faustino, Kookjoo Kim, Oliver B. Clarke, Hanxi Hou, Yaron Tomer
Summary: APS3v is an autoimmune syndrome characterized by the co-occurrence of T1D and AITD. Blocking the specific APS3v-HLA-DR3 pocket can potentially inhibit the autoimmune response, with small molecules such as S9, S5, S53, and S15 showing promise as inhibitors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Saeda Haj, Gabriel Chodick, Sophy Goren, Wasef Na'amnih, Varda Shalev, Khitam Muhsen
Summary: This study found that men infected with H. pylori were more likely to have HbA1c>7.0%, while this association was not seen in women. Additionally, both men and women infected with H. pylori had higher levels of total cholesterol and low-density lipoprotein (LDL) compared to those uninfected. No significant differences were found in glucose and high-density lipoprotein (HDL) levels based on H. pylori infection status.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Kaio Takahashi, Takatoshi Anno, Akio Matsuda, Yukiko Kimura, Fumiko Kawasaki, Kohei Kaku, Koichi Tomoda, Hirofumi Kawamoto, Hideaki Kaneto
Summary: This report presents a case of a patient with ulcerative colitis and Sjogren's syndrome who developed type 1 diabetes mellitus. The case highlights the importance of testing for thyroid-associated antibodies under various autoimmune disease conditions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Anne Chang, Anna Chang, Wan-Ting Chen, Lung Chan, Chien-Tai Hong, Li-Nien Chien
Summary: The global incidence of type 2 diabetes mellitus is increasing, and the use of antibiotics along with insulin or sulfonylureas may further increase the risk of hypoglycemia. This study found a significant association between triple therapy treatment for H. pylori infection and hypoglycemia in diabetic patients with peptic ulcer disease.
Article
Biochemistry & Molecular Biology
Ji Yeong Yang, Jong-Bae Kim, Pyeongjae Lee, Sa-Hyun Kim
Summary: Evodiamine inhibits the growth of H. pylori by downregulating gene expressions related to replication and transcription machineries of the bacteria. Moreover, evodiamine also suppresses urease expression, leading to reduced translocation of CagA and VacA proteins into AGS cells. Additionally, evodiamine inhibits the activation of signaling proteins induced by H. pylori infection, contributing to reduction of IL-8 production in AGS cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Silvia Martina Ferrari, Francesca Ragusa, Giusy Elia, Sabrina Rosaria Paparo, Valeria Mazzi, Enke Baldini, Salvatore Benvenga, Alessandro Antonelli, Poupak Fallahi
Summary: Autoimmune thyroid diseases, such as Hashimoto's thyroiditis and Graves' disease, are treated with daily synthetic L-thyroxine. Treatment with myoinositol and selenium can significantly reduce TSH and antithyroid autoantibodies levels. In rare cases, thyroidectomy may be recommended in patients with autoimmune thyroiditis. Further research is needed to investigate the impact of these new treatments on quality of life in a larger population.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Samuel Tanner, Jeffry Katz, Fabio Cominelli, Miguel Regueiro, Gregory Cooper, Emad Mansoor
Summary: This article examines the prevalence of inflammatory bowel disease in patients with gastritis, duodenitis, and peptic ulcer disease, taking into consideration the presence of Helicobacter pylori infection. It is found that inflammatory bowel disease is less common in patients with H. pylori, and there is no increased risk of developing IBD after undergoing H. pylori eradication therapy.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Pediatrics
Lihong Yang, Dongqiong Xiao, Xihong Li, Chunqi Lai, Yuhao Chen, Lingli Pan
Summary: Immune thrombocytopenia (ITP) is a common bleeding disorder in children, characterized by decreased platelet count. It can be classified into primary and secondary subtypes. The underlying mechanisms of ITP are complex and not fully understood. In this case report, an 11-year-old patient was diagnosed with ITP, Hashimoto's thyroiditis, and Helicobacter pylori (H. pylori) infection. After anti-H. pylori treatment and thyroxine supplementation, the child's platelet count increased. The limitations of this report prevent us from determining the individual effects of anti-H. pylori and thyroxine supplementation on platelet count.
FRONTIERS IN PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Mervat M. El-Eshmawy, Mona M. Arafa, Rasha R. Elzehery, Rania M. Elhelaly, Mohamed M. Elrakhawy, Azza A. El-Baiomy
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2016)
Article
Endocrinology & Metabolism
Mervat M. El-Eshmawy, Enas M. Elkhamisy, Eman Elsayed, Shaheer Kamal
DIABETES & METABOLISM JOURNAL
(2017)
Article
Rheumatology
Abd EL-Moaty Ali Afifi, Reham Magdy Shaat, OLa M. Gharbia, Yosra EL Boghdadi, Mervat Mohammad EL Eshmawy, Ola Ali El-Emam
CLINICAL RHEUMATOLOGY
(2018)
Review
Endocrinology & Metabolism
Mervat M. El-Eshmawy Supsup, Maha Shahin
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2020)
Article
Biochemistry & Molecular Biology
Hamada A. Abd El Daim, Afaf M. Elsaid, Amany A. Mousa, Mervat M. El-Eshmawy, Lashin S. Lashin, Eman A. Toraih, Rami M. Elshazli
BIOCHEMICAL GENETICS
(2020)
Article
Endocrinology & Metabolism
Mervat M. El-Eshmawy, Doaa F. Gad, Azza A. El-Baiomy
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2020)
Article
Endocrinology & Metabolism
Mervat M. El-Eshmawy, Nancy Mahsoub, Mohamed Asar, Ibrahim Elsehely
Summary: This study found an association between total bilirubin levels and metabolic and cardiovascular risk factors related to obesity. Obese adults had lower levels of total bilirubin, high density lipoprotein cholesterol (HDL-C), and AST/ALT ratio, while having higher levels of fasting insulin, insulin resistance, total cholesterol, triglycerides, low density lipoprotein cholesterol, neutrophil to lymphocyte ratio (NLR), uric acid, and gamma glutamyl transpeptidase (GGT). Total bilirubin was negatively associated with body mass index, waist circumference, fasting insulin, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), uric acid, and positively associated with HDL-C. HDL-C and NLR were independent predictor variables of total bilirubin.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Article
Endocrinology & Metabolism
Amr A. El-Sehrawy, Enas M. Elkhamisy, Amani E. Badawi, Heba A. Elshahawy, Eman El-sayed, Nehal T. Mohammed, Mervat M. El-Eshmawy
Summary: This study investigated the relationship between Subclinical Hypothyroidism (SCH) and Vascular Endothelial Growth Factor (VEGF) levels in patients with Diabetic Retinopathy (DR). The results showed that DR patients with SCH had older age, longer diabetes duration, higher HbA1c, insulin resistance, and VEGF levels compared to those with euthyroidism. In addition, Proliferative Diabetic Retinopathy (PDR), insulin resistance, and VEGF levels were significant predictors of SCH.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Editorial Material
Endocrinology & Metabolism
Mervat M. El-Eshmawy
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Article
Endocrinology & Metabolism
Mervat M. El-Eshmawy, Asmaa Ibrahim, Rania Bahriz, Nermeen Shams-Eldin, Nancy Mahsoub
Summary: This study investigates the relationship between serum uric acid/creatinine (UA/Cr) ratio and polycystic ovary syndrome (PCOS) in obese women. It finds that UA/Cr ratio is significantly higher in obese women with PCOS and is correlated with various metabolic factors. Additionally, the study shows that UA/Cr ratio and free androgen index (FAI) have an additive interaction for the detection of PCOS risk in obese women.
BMC ENDOCRINE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Sally S. S. Ahmed, Hala A. Abd El-Hafez, Mohamed Mohsen, Azza A. A. El-Baiomy, Enas T. T. Elkhamisy, Mervat M. M. El-Eshmawy
Summary: This study aimed to explore the possible association between vitamin B12 deficiency and gastroparesis in patients with type 2 diabetes. The results found that vitamin B12 deficiency is an independent predictor of gastroparesis in patients with type 2 diabetes.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zizi Moustafa Hassan El-Mewafy, Ahmed Abdel Khalek Abdel Razek, Mervat Mohamed El-Eshmawy, Nader Ramadan Abo El-Eneen, Azaa Abdel Baky EL-Biaomy
POLISH JOURNAL OF RADIOLOGY
(2018)