Article
Multidisciplinary Sciences
Lashodya V. Dissanayake, Adrian Zietara, Vladislav Levchenko, Denisha R. Spires, Mariana Burgos Angulo, Ashraf El-Meanawy, Aron M. Geurts, Melinda R. Dwinell, Oleg Palygin, Alexander Staruschenko
Summary: The dysregulation of uric acid homeostasis is detrimental to cardiovascular and kidney health. This study established a rat model with the genetic ablation of the Xdh gene and found that the absence of Xdh leads to the accumulation of uric acid metabolites in the kidney, resulting in severe kidney injury and functional decline.
Article
Biochemistry & Molecular Biology
Dean Gilham, Sylwia Wasiak, Brooke D. Rakai, Li Fu, Laura M. Tsujikawa, Christopher D. Sarsons, Agostina Carestia, Kenneth Lebioda, Jan O. Johansson, Michael Sweeney, Kamyar Kalantar-Zadeh, Ewelina Kulikowski
Summary: Apabetalone can inhibit the progression of chronic kidney disease by suppressing the activation of renal mesangial cells and reducing the expression of genes associated with fibrosis, inflammation, and calcification. This drug also reduces the risk of major adverse cardiac events in CKD patients.
Article
Biochemistry & Molecular Biology
Wei-Sheng Wu, Tzu-Hsien Yang, Kuang-Den Chen, Po-Heng Lin, Guan-Ru Chen, Ho-Chang Kuo
Summary: Kawasaki disease (KD) is an acute systemic vasculitis that primarily affects children and is the most common cause of acquired heart disease. The etiology of KD is unknown, but differential methylation and gene expression analysis have identified genes involved in the disease mechanisms. Researchers have developed a database called KDmarkers to provide access to these potential KD biomarkers.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Peripheral Vascular Disease
Jing Liu, Yong Liu, Feng Wang, Mingyu Liang
Summary: miR-204 is a high-value microRNA that plays a critical role in regulating cardiovascular and renal physiology, exhibiting tissue-specific expression patterns and being influenced by multiple regulatory mechanisms. It attenuates pulmonary arterial hypertension and renal injury while promoting hypertension and endothelial dysfunction, potentially impacting disease processes through targeting various biological pathways. Dysregulation of miR-204 in cardiovascular and renal diseases highlights its unequivocal functional roles and clinical relevance.
Article
Multidisciplinary Sciences
Christian Escoto-Sandoval, Alan Flores-Diaz, M. Humberto Reyes-Valdes, Neftali Ochoa-Alejo, Octavio Martinez
Summary: A methodology was developed to transform RNA-Seq data from time course experiments into standardized expression profiles, facilitating analysis of gene expression changes during chili pepper fruit development. The developed R package Salsa provides researchers with valuable tools and insights for studying fruit development in chili peppers and other angiosperms.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yimin Zheng, Yitian Chen, Xianting Ding, Koon Ho Wong, Edwin Cheung
Summary: Spatial omics is an approach that integrates spatial knowledge with transcript or protein expression information to explore tissue microenvironment and cellular networks. However, there is a lack of databases for users to access and analyze spatial omics data. To address this limitation, Aquila, a comprehensive platform for managing and analyzing spatial omics data, has been developed. Aquila contains 107 datasets from 30 diseases, covering studies using different technologies.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yang Li, Xiuli Lu, Zhihao Yu, Haozhen Wang, Bing Gao
Summary: In this study, it was found that ATP1A1 may be a key susceptibility gene involved in calcium stone formation. The down-regulation of ATP1A1 was associated with crystal deposition and activation of related signaling pathways. Overexpression of ATP1A1 or treatment with a specific inhibitor alleviated oxidative stress, inflammation, apoptosis, crystal-cell adhesion, and stone formation. These findings suggest that ATP1A1 could be a potential therapeutic target for treating calcium stones.
Article
Endocrinology & Metabolism
Shen Li, Mengxuan Cui, Yingshu Liu, Xuhan Liu, Lan Luo, Wei Zhao, Xiaolan Gu, Linfeng Li, Chao Liu, Lan Bai, Di Li, Bo Liu, Defei Che, Xinyu Li, Yao Wang, Zhengnan Gao
Summary: By studying patients with T2D, we identified 6 prevalent metabolic profiles and found that severe hyperglycemia and moderate dyslipidemia are significant risk markers for DKD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Ruofan Ding, Qixuan Wang, Lihai Gong, Ting Zhang, Xudong Zou, Kewei Xiong, Qi Liao, Mireya Plass, Lei Li
Summary: Researchers have developed a comprehensive database called scQTLbase for searching, analyzing, and visualizing single-cell expression quantitative trait loci (sc-eQTLs). The database includes 304 datasets spanning 57 cell types and 95 cell states. It offers various functionalities such as gene expression visualization, a genome browser, and colocalization visualization based on GWAS datasets.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Oncology
Landon C. Brown, Jason Zhu, Kunal Desai, Emily Kinsey, Chester Kao, Yong Hee Lee, Sarabjot Pabla, Matthew K. Labriola, Jennifer Tran, Konstantin H. Dragnev, Laura J. Tafe, Farshid Dayyani, Rajan T. Gupta, Shannon McCall, Daniel J. George, Sean T. Glenn, Mary K. Nesline, Saby George, Matthew Zibelman, Carl Morrison, Moshe C. Ornstein, Tian Zhang
Summary: This study utilized the OmniSeq transcriptome-based platform to develop biomarkers of response to immunotherapy. A 5-gene panel was identified that was associated with improved objective response rate (ORR) in patients treated with nivolumab monotherapy for metastatic renal cell carcinoma (mRCC). However, this gene panel was not predictive for treatment response in patients receiving ipilimumab and nivolumab combination therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Jung Kwon Kim, Gyoohwan Jung, Cheol Kwak, Chang Wook Jeong, Seok Ho Kang, Sung-Hoo Hong, Yong-June Kim, Jinsoo Chung, Eu Chang Hwang, Tae Gyun Kwon, Seok-Soo Byun
Summary: In this study, the survival outcomes of octogenarian and younger renal cell carcinoma (RCC) patients were compared after surgery. The results showed that the octogenarian group had comparable survival outcomes as the younger group after propensity score matching analysis. Therefore, active treatment can be considered in octogenarian patients with good performance status.
Article
Oncology
Robert J. Motzer, Toni K. Choueiri, David F. McDermott, Thomas Powles, Yann-Alexandre Vano, Saurabh Gupta, Jin Yao, Celine Han, Ron Ammar, Simon Papillon-Cavanagh, Shruti S. Saggi, M. Brent McHenry, Petra Ross-Macdonald, Megan Wind-Rotolo
Summary: The study found that biomarkers previously associated with immune checkpoint inhibitor-containing regimens were not predictive for survival in RCC patients treated with nivolumab plus ipilimumab. However, gene expression analysis revealed an association between an inflammatory response and progression-free survival in patients receiving this treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Olga Haberkiewicz, Pawel Lipinski, Rafal R. Starzynski, Aneta Jonczy, Patrycja Kurowska, Mateusz Ogorek, Aleksandra Bednarz, Sylwia Herman, Dawid Hatala, Pawel Grzmil, Zenon Rajfur, Zbigniew Baster, Malgorzata Lenartowicz
Summary: Kidneys play a unique role in copper redistribution in the body, controlling copper uptake and release through copper transporters. The study showed changes in the expression and localization of CTR1 protein in the kidneys of copper-overloaded mosaic mutant mice, preventing copper transport and protecting cells from copper toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Mingrui Li, Minxin He, Fangshi Xu, Yibing Guan, Juanhua Tian, Ziyan Wan, Haibin Zhou, Mei Gao, Tie Chong
Summary: This study investigated the role and significance of AQPs in ccRCC, identifying AQPs that are associated with the prognosis of ccRCC and suggesting their potential as new survival markers for targeted therapy.
Article
Biochemistry & Molecular Biology
Yushan Deng, Yubao Lu, Mengrou Li, Jiayi Shen, Siying Qin, Wei Zhang, Qiang Zhang, Zhaoyang Shen, Changxiao Li, Tengfei Jia, Peixin Chen, Lingmin Peng, Yangfeng Chen, Wensheng Zhang, Hebin Liu, Liangming Zhang, Limin Rong, Xiangdong Wang, Dongsheng Chen
Summary: The nervous system is a complex and mysterious system in the animal kingdom. Recent advancements in spatial transcriptomics and single-cell RNA sequencing technologies have allowed for a better understanding of the cellular heterogeneity and spatial locations of the nervous system. This study collected and analyzed a large amount of high-quality data to comprehensively explore the neural system. Additionally, the study systematically analyzed various neurological disorders to identify potential biomarkers.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Clinical Neurology
Bo Yang, Jiaruo Xu, Qiang Xue, Tingting Wei, Jing Xu, Chaoyang Ye, Changlin Mei, Zhiguo Mao
SLEEP MEDICINE REVIEWS
(2015)
Review
Medicine, General & Internal
Bo Yang, Sixiu Chen, Guang Yang, Changlin Mei, Albert Ong, Zhiguo Mao
Article
Urology & Nephrology
Cheng Xue, Bo Yang, Chenchen Zhou, Bing Dai, Yawei Liu, Zhiguo Mao, Shengqiang Yu, Changlin Mei
AMERICAN JOURNAL OF NEPHROLOGY
(2017)
Article
Genetics & Heredity
Wen Li, Yiyi Ma, Shengqiang Yu, Ningxia Sun, Liang Wang, Dongping Chen, Guijiang Yang, Sijia Lu, Yangyang Li, Bo Yang, Changlin Mei
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2017)
Article
Biotechnology & Applied Microbiology
Mohan Babu, Cedoljub Bundalovic-Torma, Charles Calmettes, Sadhna Phanse, Qingzhou Zhang, Yue Jiang, Zoran Minic, Sunyoung Kim, Jitender Mehla, Alla Gagarinova, Irina Rodionova, Ashwani Kumar, Hongbo Guo, Olga Kagan, Oxana Pogoutse, Hiroyuki Aoki, Viktor Deineko, J. Harry Caufield, Erik Holtzapple, Zhongge Zhang, Ake Vastermark, Yogee Pandya, Christine Chieh-lin Lai, Majida El Bakkouri, Yogesh Hooda, Megha Shah, Dan Burnside, Mohsen Hooshyar, James Vlasblom, Sessandra V. Rajagopala, Ashkan Golshani, Stefan Wuchty, Jack F. Greenblatt, Milton Saier, Peter Uetz, Trevor F. Moraes, John Parkinson, Andrew Emili
NATURE BIOTECHNOLOGY
(2018)
Article
Oncology
Gerrit Kuerschner, Qingzhou Zhang, Rosanna Clima, Yi Xiao, Jonas Felix Busch, Ergin Kilic, Klaus Jung, Nikolaus Berndt, Sascha Bulik, Hermann-Georg Hoelzhutter, Giuseppe Gasparre, Marcella Attimonelli, Mohan Babu, David Meierhofer
Article
Multidisciplinary Sciences
Bo Yang, Sixiu Chen, Ming Wu, Lin Zhang, Mengna Ruan, Xujiao Chen, Zhengjun Chen, Changlin Mei, Zhiguo Mao
SCIENTIFIC REPORTS
(2017)
Article
Medicine, General & Internal
Cheng Xue, Chenchen Zhou, Bo Yang, Jiayi Lv, Bing Dai, Shengqiang Yu, Yi Wang, Guanren Zhao, Changlin Mei
Review
Urology & Nephrology
Cheng Xue, Bo Yang, Jing Xu, Chenchen Zhou, Liming Zhang, Xiang Gao, Bing Dai, Shengqiang Yu, Zhiguo Mao, Changlin Mei, Chenggang Xu
Summary: Rituximab (RTX) may be an effective and relatively safe alternative for the treatment of adult frequent-relapsing or steroid-dependent nephrotic syndrome patients. Patients with minimal change disease have a higher complete remission rate with RTX, while those with focal segmental glomerulosclerosis have a lower remission rate and further investigation is needed on long-term adverse events.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Urology & Nephrology
Dian Fu, Bo Yang, Jing Xu, Zhiguo Mao, Chenchen Zhou, Cheng Xue
Article
Multidisciplinary Sciences
Mohamed Taha Moutaoufik, Ramy Malty, Shahreen Amin, Qingzhou Zhang, Sadhna Phanse, Alla Gagarinova, Mara Zilocchi, Larissa Hoell, Zoran Minic, Maria Gagarinova, Hiroyuki Aoki, Jocelyn Stockwell, Matthew Jessulat, Florian Goebels, Kirsten Broderick, Nichollas E. Scott, James Vlasblom, Gabriel Musso, Bhanu Prasad, Eleonora Lamantea, Barbara Garavaglia, Alex Rajput, Kei Murayama, Yasushi Okazaki, Leonard J. Foster, Gary D. Bader, Francisco S. Cayabyab, Mohan Babu
Article
Physiology
Bo Yang, Lili Fu, Jamie R. Privratsky, Xiaohan Lu, Tiafa Ren, Changlin Mei, Steven D. Crowley
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)
Review
Pharmacology & Pharmacy
X-J Zang, B. Yang, X. Du, C-L Mei
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2019)
Article
Nutrition & Dietetics
Dongmei Liu, Ming Wu, Lin Li, Xiang Gao, Bo Yang, Shuqin Mei, Lili Fu, Changlin Mei
BRITISH JOURNAL OF NUTRITION
(2018)
Review
Medicine, General & Internal
Zui Zou, Hong B. Yuan, Bo Yang, Fengying Xu, Xiao Y. Chen, Guan J. Liu, Xue Y. Shi
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2016)
