Article
Clinical Neurology
Tong Guo, Yuan Yang, Qian Zhao, Lei Zhang, Chee H. Ng, Teris Cheung, Yang Li, Xue-Quan Zhu, Xiao-Hong Li, Yu-Tao Xiang
Summary: The study aimed to assess the clinical phenomenology and characteristics of prodromal symptoms in Chinese patients with bipolar disorder prior to their index mood episode. The findings indicated that identifying prodromal symptoms of BPD may be beneficial for early diagnosis and intervention before the development of full episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Raphael O. Cerqueira, Carolina Ziebold, Daniel Cavalcante, Giovany Oliveira, Javiera Vasquez, Juan Undurraga, Alfonso Gonzalez-Valderrama, Ruben Nachar, Carlos Lopez-Jaramillo, Cristiano Noto, Nicolas Crossley, Ary Gadelha
Summary: This study compares patients with affective and non-affective psychosis (A-FEP and NA-FEP) in a Latin American sample. The findings suggest that characteristics of FEP patients could be utilized to enhance diagnosis and inform treatment decisions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Michael J. Spoelma, Katherine M. Ponte, Gordon Parker
Summary: This study aimed to identify common concerns of caregivers in the management of individuals with bipolar disorder. The results showed that concerns about work capacity and family impacts were almost ubiquitous, along with general feelings of ineffectiveness and irritation. Caregivers were more likely to fear suicide during depressive phases, while they were more likely to experience anger, concerns for their own safety, and take safety precautions during hypo/manic phases.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Psychiatry
Marta Migo, Kendra Simpson, Amy Peters, Kristen K. Ellard, Tina Chou, Andrew A. Nierenberg, Darin D. Dougherty, Thilo Deckersbach
Summary: By dimensionally analyzing symptom severity in patients with bipolar disorder, more accurate differences in neural responses to emotional stimuli can be captured. There is a correlation between symptom severity and brain activation, with depression severity associated with increased activation in various brain regions and mania severity associated with both increased and decreased activation.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Gordon Parker, Michael J. Spoelma, Gabriela Tavella, Martin Alda, Tomas Hajek, David L. Dunner, Claire O'Donovan, Janusz K. Rybakowski, Joseph F. Goldberg, Adam Bayes, Verinder Sharma, Philip Boyce, Vijaya Manicavasagar
Summary: The study used machine learning to identify highly discriminating symptoms between bipolar disorder and unipolar depression patients, assisting clinicians in distinguishing between the two conditions. Despite the unbalanced sample, the prediction rule ensembles showed potential in accuracy and may supersede traditional classificatory approaches.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Alexandru I. Tiba, Simona Trip, Carmen H. Bora, Marius Drugas, Feliciana Borz, Daiana C. Miclaus, Laura Voss, Sorin C. Iova, Simona Pop
Summary: Primary irrational beliefs, especially those related to positive events, are found to be significantly associated with the risk of Bipolar Disorder. These findings highlight the importance of addressing positive primary irrational beliefs in the treatment of BPD.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Psychiatry
Anna Grunze, Christoph Born, Mette U. Fredskild, Heinz Grunze
Summary: The DSM-5 redefined the criteria for diagnosing hypomanic/manic episodes, adding increased energy/activity to the previous mood change criterion. Research indicates that this change may lead to a decrease of at least one third in the prevalence of manic/hypomanic episodes, but its impact on clinical practice and research requires further evaluation.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Digby J. Quested, Jessica C. Gibson, Ann L. Sharpley, Julia H. Cordey, Alexis Economou, Franco De Crescenzo, Merryn Voysey, Jennifer Lawson, Jennifer M. Rendell, Hasanen Al-Taiar, Alison Lennox, Farooq Ahmad, John R. Geddes
Summary: The study compared the effectiveness and safety of adding melatonin in treating emergent episodes of hypomania or mania in bipolar disorder over a 3-week period. The results showed that melatonin did not effectively treat emerging hypomania or mania, as there was no significant difference between melatonin and placebo on the primary outcome.
Article
Psychiatry
Manuel Gardea-Resendez, Javier Ortiz-Orendain, Alessandro Miola, Manuel Fuentes Salgado, Mete Ercis, Brandon J. Coombes, Peggy M. Gruhlke, J. Michael Bostwick, Ian Michel, Jennifer L. Vande Voort, Aysegul Ozerdem, Alastair McKean, Mark A. Frye, Monica Taylor-Desir
Summary: This study compares psychiatric diagnoses and psychotropic drug use before the first episode of mania or psychosis in racially diverse patients. The findings indicate that non-White patients had a shorter duration of psychiatric antecedents and sought mental health care at an older age compared to White patients. There were no significant differences in pathways to care or age of first seeking mental health between racial groups, but non-White patients had lower rates of psychotropic drug use.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Gordon Parker
Summary: The 2020 College guidelines exclude bipolar II disorder and argue against partitioning bipolar disorder into separate sub-types, but the author challenges this single-entity model and suggests potential risks in clinical management.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2021)
Review
Psychiatry
Gordon Parker, Michael J. Spoelma, Gabriela Tavella
Summary: By reviewing the criteria in the DSM-5 for defining mania/hypomania and bipolar I/II disorders, an expert taskforce has developed modified criteria and a potential bipolar screening measure to differentiate between bipolar and unipolar status. This revised criteria aims to overcome limitations in defining and differentiating the two bipolar sub-types, while still respecting the DSM template, pending further validation of its superiority over existing measures.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Clinical
Chiao-Erh Chang, Jui Wang, Yi-Ting Lin, Chih-Chiang Chiu, Ming-Hsien Hsieh, Ming-Chyi Huang, Mong-Liang Lu, Hsi-Chung Chen, Wei J. Chen, Po-Hsiu Kuo
Summary: This study compared the clinical features, psychosocial characteristics, and comorbidity patterns between the unipolar mania (UM) and depressive-manic (D-M) subgroups. The results showed that compared to the D-M group, the UM group had more psychotic symptoms, a higher proportion of morningness chronotype, better sleep quality, higher extraversion, lower neuroticism, and less harm avoidance personality traits. Additionally, different lifetime comorbidity patterns were observed between the two groups.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychiatry
Julie Ramain, Philippe Conus, Philippe Golay
Summary: This study aimed to consolidate current knowledge on first-episode affective psychoses and identify areas for further investigation. The results showed heterogeneity in diagnosis-related grouping under the concept of affective psychoses, indicating a need for specialized intervention for patients with different psychopathological and neurocognitive profiles.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Christoph Born, Heinz Grunze, Robert M. Post, Lori L. Altshuler, Ralph Kupka, Susan L. McElroy, Mark A. Frye, Trisha Suppes, Paul E. Keck, Willem A. Nolen, Lars Schaerer
Summary: This study analyzed the presence of depressive symptoms in bipolar disorder patients and found that (hypo)manic states are associated with a higher burden of depression compared to non-(hypo)manic states. Female patients were more likely to exhibit depressive symptoms, and mania and depression were shown to complement each other rather than being opposing poles.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2021)
Article
Psychology, Clinical
Talia R. Berson, Kathryn C. Kemp, Alyssa J. Bathery, Neus Barrantes-Vidal, Thomas R. Kwapil
Summary: The study found that subclinical expressions of bipolar spectrum psychopathology are associated with psychotic-like and schizotypic symptoms consistent with features of bipolar disorders. There is a shared dimension of psychosis that extends through subclinical functioning in both the bipolar and schizophrenia spectrum psychopathologies.
JOURNAL OF PSYCHOPATHOLOGY AND BEHAVIORAL ASSESSMENT
(2021)
Article
Biochemistry & Molecular Biology
Maria Rogdaki, Celine Devroye, Mariasole Ciampoli, Mattia Veronese, Abhishekh Ashok, Robert A. McCutcheon, Sameer Jauhar, Ilaria Bonoldi, Maria Gudbrandsen, Eileen Daly, Therese van Amelsvoort, Marianne Van Den Bree, Michael J. Owen, Federico Turkheimer, Francesco Papaleo, Oliver D. Howes
Summary: Dopaminergic dysfunction is associated with genetic risk for psychosis, particularly in individuals with 22q11.2 deletion. This study found increased striatal dopamine synthesis capacity in individuals with 22q11.2 deletion compared to healthy controls and individuals with 22q11.2 duplication. Furthermore, dopamine synthesis was positively correlated with the severity of psychosis-risk symptoms.
MOLECULAR PSYCHIATRY
(2023)
Correction
Biochemistry & Molecular Biology
Maria Rogdaki, Celine Devroye, Mariasole Ciampoli, Mattia Veronese, Abhishekh H. Ashok, Robert A. McCutcheon, Sameer Jauhar, Ilaria Bonoldi, Maria Gudbrandsen, Eileen Daly, Therese van Amelsvoort, Marianne Van Den Bree, Michael J. Owen, Federico Turkheimer, Francesco Papaleo, Oliver D. Howes
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Clinical
Toby Pillinger, Robert A. McCutcheon, Oliver D. Howes
Summary: Patients with first-episode psychosis (FEP) show greater variability in metabolic parameters compared to controls, indicating potential subgroups of patients with more susceptibility to metabolic dysregulation. Female sex and higher symptom severity are associated with poorer metabolic outcomes.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Emma Butler, Toby Pillinger, Kirsten Brown, Faith Borgan, Alice Bowen, Katherine Beck, Enrico D'Ambrosio, Lisa Donaldson, Sameer Jauhar, Stephen Kaar, Tiago Reis Marques, Robert A. McCutcheon, Maria Rogdaki, Fiona Gaughran, James MacCabe, Rosalind Ramsay, David Taylor, Paul McCrone, Alice Egerton, Oliver D. Howes
Summary: This study demonstrates the feasibility of community initiation of clozapine for treatment-resistant schizophrenia. It is associated with significant reductions in costs, service use, and symptom severity.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
Matthew B. Wall, Tom P. Freeman, Chandni Hindocha, Lysia Demetriou, Natalie Ertl, Abigail M. Freeman, Augustus P. M. Jones, Will Lawn, Rebecca Pope, Claire Mokrysz, Daniel Solomons, Ben Statton, Hannah R. Walker, Yumeya Yamamori, Zixu Yang, Jocelyn L. L. Yim, David J. Nutt, Oliver D. Howes, H. Valerie Curran, Michael A. P. Bloomfield
Summary: This study aimed to investigate the effects of THC, CBD, and THC + CBD on functional connectivity in the brain. The results showed that both THC and THC + CBD had strong disruptive effects on the associative and sensorimotor networks, but only THC had a specific effect on the limbic striatum network. In addition, oral CBD increased connectivity in the associative network, but had relatively minor effects on the limbic and sensorimotor networks.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Review
Psychology, Clinical
Leigh Townsend, Toby Pillinger, Pierluigi Selvaggi, Mattia Veronese, Federico Turkheimer, Oliver Howes
Summary: This study investigates brain metabolism in patients with schizophrenia and finds evidence of lower glucose metabolism in the frontal cortex, supporting the hypothesis of hypofrontality in schizophrenia. However, there were no consistent alterations in other brain regions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Enrico D'Ambrosio, Giulio Pergola, Antonio F. Pardinas, Tarik Dahoun, Mattia Veronese, Leonardo Sportelli, Paolo Taurisano, Kira Griffiths, Sameer Jauhar, Maria Rogdaki, Michael A. P. Bloomfield, Sean Froudist-Walsh, Ilaria Bonoldi, James T. R. Walters, Giuseppe Blasi, Alessandro Bertolino, Oliver D. Howes
Summary: The D2 dopamine receptor is crucial for the therapeutic effects of antipsychotics and plays a role in various brain functions related to schizophrenia. The gene coding for D2 receptor has been associated with schizophrenia, and recent studies suggest a link between a network of genes co-expressed with D2 receptor and antipsychotic response and brain function in schizophrenia patients. This study investigates the relationship between the DRD2 gene network and striatal dopaminergic function in healthy subjects, and findings suggest a potential mechanism involving the regulation of dopamine synthesis.
SCIENTIFIC REPORTS
(2022)
Review
Neurosciences
Oliver D. Howes, Connor Cummings, George E. Chapman, Ekaterina Shatalina
Summary: This article provides an overview of the evidence on structural and metabolic brain alterations in schizophrenia, suggesting the presence of lower synaptic density in certain brain regions. However, there are still gaps in evidence that need further investigation.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Clinical
Pierluigi Selvaggi, Sameer Jauhar, Vasileia Kotoula, Fiona Pepper, Mattia Veronese, Barbara Santangelo, Fernando Zelaya, Federico E. Turkheimer, Mitul A. Mehta, Oliver D. Howes
Summary: This study found significantly lower frontal cortical blood flow in FEP patients before antipsychotic treatment. Additionally, the relative-to-global frontal cerebral blood flow measured before antipsychotic treatment may be associated with treatment response.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Stephen J. Kaar, Judith F. Nottage, Ilinca Angelescu, Tiago Reis Marques, Oliver D. Howes
Summary: A study found that a potassium channel modulator called AUT00206 has a significant effect on frontal resting gamma power in people with schizophrenia, potentially improving their symptoms.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Review
Neurosciences
Els F. Halff, Grazia Rutigliano, Anna Garcia-Hidalgo, Oliver D. Howes
Summary: Schizophrenia is a major health burden and new treatment approaches are needed. Targeting the trace amine (TA) system shows potential, as supported by genetic, preclinical, and clinical evidence. The trace amine-associated receptor 1 (TAAR1) is positioned to modulate key brain circuits for schizophrenia through its localization and function. Animal studies using TAAR1 agonists have shown promising results in inhibiting dopamine and serotonin activity, enhancing glutamatergic function, and improving symptoms and cognitive measures. Clinical trials of TAAR1 agonists may address unmet needs in the treatment of schizophrenia, including psychotic and negative symptoms and tolerability issues.
TRENDS IN NEUROSCIENCES
(2023)
Editorial Material
Psychiatry
Oliver D. Howes, Luke Baxter
Article
Endocrinology & Metabolism
Giovanna Nordio, Rubaida Easmin, Alessio Giacomel, Ottavia Dipasquale, Daniel Martins, Steven Williams, Federico Turkheimer, Oliver Howes, Mattia Veronese, Sameer Jauhar, Maria Rogdaki, Robert McCutcheon, Stephen Kaar, Luke Vano, Grazia Rutigliano, Ilinca Angelescu, Faith Borgan, Enrico D'Ambrosio, Tarik Dahoun, Euitae Kim, Seoyoung Kim, Micheal Bloomfield, Alice Egerton, Arsime Demjaha, Ilaria Bonoldi, Chiara Nosarti, James Maccabe, Philip McGuire, Julian Matthews, Peter S. Talbot
Summary: In this study, a fully automated analytical framework for FDOPA PET neuroimaging data was evaluated. The framework showed good reproducibility and sensitivity to demographic and experimental variables. It represents an effective resource for standardized and robust quantification of dopamine synthesis capacity using FDOPA PET data.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Psychiatry
Elias Wagner, Dan Siskind, Peter Falkai, Oliver Howes, Christoph Correll, Jimmy Lee, William G. Honer, John M. Kane, Emilio Fernandez-Egea, Thomas R. E. Barnes, Alkomiet Hasan
Summary: This study conducted an online Delphi survey to develop consensus recommendations for the optimization of clozapine monotherapy. The recommendations include specific treatment options for certain symptoms and management of side effects. The study results provide guidance for clinical decision-making and future research in treatment-resistant schizophrenia.
SCHIZOPHRENIA BULLETIN
(2023)
Meeting Abstract
Psychiatry
E. F. Osimo, B. Perry, P. Mallikarjun, G. Murray, O. Howes, P. Jones, R. Upthegrove, G. Khandaker
EUROPEAN PSYCHIATRY
(2022)
