Article
Clinical Neurology
Mehmet Kemal Arikan, Guven Gunver, Reyhan Ilhan, Ozden Oksuz, Baris Metin
Summary: This study found that patients who did not respond to aripiprazole had significantly higher gamma power compared to aripiprazole responders. This suggests that gamma power may serve as a potential biomarker for unresponsiveness to aripiprazole treatment in patients with bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Duan Liu, Yongxian Zhuang, Lingxin Zhang, Huanyao Gao, Drew Neavin, Tania Carrillo-Roa, Yani Wang, Jia Yu, Sisi Qin, Daniel C. Kim, Erica Liu, Thanh Thanh Le Nguyen, Joanna M. Biernacka, Rima Kaddurah-Daouk, Boadie W. Dunlop, W. Edward Craighead, Helen S. Mayberg, Elisabeth B. Binder, Mark A. Frye, Liewei Wang, Richard M. Weinshilboum
Summary: ERICH3 gene may play a significant role in vesicular function in serotonergic and other neuronal cell types, which could help explain its association with plasma serotonin concentrations and SSRI clinical response.
MOLECULAR PSYCHIATRY
(2021)
Article
Chemistry, Analytical
Seong Soon Kim, Ha-Yeon Lee, Jin Sook Song, Myung-Ae Bae, Sunjoo Ahn
Summary: Depression is often characterized by deficiencies in monoamine neurotransmitters in the central nervous system. Antidepressants work by increasing levels of neurotransmitters such as dopamine, norepinephrine, and serotonin. Neurochemical profiling can help understand brain chemistry and neurotoxicity in the discovery and development of CNS drugs. Through this approach, researchers confirmed the modulation of serotonin and dopamine in the mouse brain following treatment with nefazodone.
MICROCHEMICAL JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Emilio Berna-Rico, Javier Perez-Bootello, Carlota Abbad-Jaime de Arago, Alvaro Gonzalez-Cantero
Summary: Psoriasis is a chronic inflammatory disease with a genetic background. Genetic variations in HLA-Cw*06 allele and genes related to inflammation and keratinocyte proliferation have been associated with disease development. This review assessed the evidence on how these genetic variations may affect the response to psoriasis treatment. Variations in VDR gene may influence topical vitamin D and phototherapy response, while variations in ABC transporter genes are associated with methotrexate and cyclosporine outcomes. Multiple single-nucleotide polymorphisms related to anti-TNF-α response modulation show conflicting results. HLA-Cw*06 has been extensively studied and related to ustekinumab response. Further research is needed to establish the usefulness of these genetic biomarkers in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Anne Krogh Nohr, Annika Forsingdal, Ida Moltke, Oliver D. Howes, Morana Vitezic, Anders Albrechtsen, Maria Dalby
Summary: This study investigates the association between polygenic risk scores (PRSs) for relevant complex traits and response to vortioxetine treatment and placebo. The results suggest that PRSs may be associated with treatment response and placebo response, but the explained variance is relatively low.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychology, Multidisciplinary
Marek Susta, Gustav Bizik, Anna Yamamotova, Svojmil Petranek, Marie Kadochova, Hana Papezova
Summary: This study aims to identify the differences in brain activity between participants with anorexia nervosa and healthy controls using visual stimulus conditions combined with the quantitative dense-array EEG recording analysis method called Brain Activation Sequences (BAS). The results showed distinct patterns of brain activation in response to facial expressions of disgust and body images in individuals with anorexia, which may contribute to social-cognitive and behavioral impairments. The differences in brain activation patterns within the participants with anorexia and its association with treatment resistance deserve special attention, as they have the potential to develop clinically useful prediction tools and identify targets for neuromodulatory treatments and/or individualized psychotherapy.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Medicine, General & Internal
Michal Skalski, Anna Mach, Piotr Januszko, Beata Ryszewska-Pokrasniewicz, Agata Biernacka, Gabriel Nowak, Andrzej Pilc, Ewa Poleszak, Maria Radziwon-Zaleska
Summary: The study aimed to evaluate the effects of psychotropic medications on the bioelectrical activity of the brain using pharmaco-EEG. Results showed the highest treatment response in the group receiving fluoxetine augmented with Mg ions, while the group receiving tricyclic antidepressants had the lowest response rates. Achieving remission was associated with a positive pharmaco-EEG profile 6 hours after administration of the first dose in the fluoxetine+Mg group.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Roselinde H. Kaiser, Henry W. Chase, Mary L. Phillips, Thilo Deckersbach, Ramin V. Parsey, Maurizio Fava, Patrick J. McGrath, Myrna Weissman, Maria A. Oquendo, Melvin G. McInnis, Thomas Carmody, Crystal M. Cooper, Madhukar H. Trivedi, Diego A. Pizzagalli
Summary: This study aimed to address the lack of objective tools for predicting or monitoring antidepressant treatment response by testing novel dynamic resting-state functional network markers. The findings suggest that early dynamic network markers of sertraline response may assist in the development of clinical tools for monitoring and predicting effective intervention.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Tomasz Wysocki, Agnieszka Paradowska-Gorycka
Summary: Rheumatoid arthritis is a common inflammatory arthritis in which tumor necrosis factor plays a key role. However, there is variation in response to TNF-targeting drugs, which may be influenced by genetic factors. The field of pharmacogenomics offers potential for developing novel prognostic tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Caren Armstrong, Alexis Zavez, Patrick J. Mulcahey, Yoshimi Sogawa, Jill M. Gotoff, Samantha Hagopian, Jennie Minnick, Eric D. Marsh
Summary: This study analyzed the effects of cannabidiol (CBD) treatment on the EEG of patients with refractory epilepsy. The results suggest that there are subtle changes in certain metrics detected by quantitative EEG (qEEG) even at baseline that may be used as a biomarker to predict a patient's clinical response to CBD administration. This finding is important for reducing unnecessary medication exposure and improving outcomes for patients with epilepsy.
Article
Clinical Neurology
Giuseppe Fanelli, Katharina Domschke, Alessandra Minelli, Massimo Gennarelli, Paolo Martini, Marco Bortolomasi, Eduard Maron, Alessio Squassina, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Diego Albani, Gianluigi Forloni, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Diana De Ronchi, Bernhard T. Baune, Alessandro Serretti, Chiara Fabbri
Summary: The study investigated the possible association of polygenic risk scores (PRSs) for bipolar disorder, major depressive disorder (MDD), neuroticism, and schizophrenia (SCZ) with antidepressant non-response or non-remission in patients with MDD. Results did not show significant associations after Bonferroni correction, but a potential link was found between MDD-PRS and non-remission. Methodological improvements in PRS calculation may enhance their predictive performance in precision psychiatry.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Dekel Taliaz, Amit Spinrad, Ran Barzilay, Zohar Barnett-Itzhaki, Dana Averbuch, Omri Teltsh, Roy Schurr, Sne Darki-Morag, Bernard Lerer
Summary: This study utilized machine learning algorithms to analyze genetic, clinical, and demographic factors in patients with major depressive disorder, generating an accurate predictive algorithm for antidepressant response. The results showed improved accuracy in individualized antidepressant prescription, supporting the feasibility of using ML algorithms applied to large datasets to enhance treatment selection.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Immunology
Bryna L. Fitzgerald, Barbara Graham, Mark J. Delorey, Adoracion Pegalajar-Jurado, M. Nurul Islam, Gary P. Wormser, John N. Aucott, Alison W. Rebman, Mark J. Soloski, John T. Belisle, Claudia R. Molins
Summary: This study used metabolomics to analyze metabolic responses in patients with Post-treatment Lyme disease symptoms/syndrome (PTLDS) compared to clinically cured non-PTLDS patients. The findings revealed observable metabolic differences between PTLDS and non-PTLDS patients at multiple time points, with distinct patterns of metabolite abundance. A small number of metabolites could be used to define PTLDS versus non-PTLDS patients at specific time points, and these findings were validated in a second patient cohort. These results suggest that metabolite-based measurement can help distinguish patients with PTLDS and provide insights into the underlying biochemistry of PTLDS.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Medicine, General & Internal
Jacob T. Bjerrum, Yulan L. Wang, Jakob B. Seidelin, Ole H. Nielsen
Summary: Metabonomics in inflammatory bowel disease (IBD) aims to describe molecular phenotypes, predict disease course and response to treatment, and facilitate precision medicine. While promising for clinical applications, understanding and implementation of metabonomics in IBD remains a challenge.
Article
Psychology, Clinical
E. Loeb, K. El Asmar, S. Trabado, F. Gressier, R. Colle, A. Rigal, S. Martin, C. Verstuyft, B. Feve, P. Chanson, L. Becquemont, E. Corruble
Summary: This study found that depressed patients have decreased NOS activity compared to healthy controls, and it improves after antidepressant treatment. NOS activity may be a promising biomarker for major depressive episodes in the context of major depressive disorder.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Nako Nakatsuka, John M. Abendroth, Kyung-Ae Yang, Anne M. Andrews
Summary: Oligonucleotide receptors (aptamers) undergo conformational changes upon target recognition, with the new dopamine aptamer showing significant responses to Mg2+ and Ca2+ in high ionic-strength conditions. While divalent cation-associated signal amplification was observed for the new dopamine aptamer, it was not seen in the serotonin aptamer or the old dopamine aptamer, indicating allosteric binding interactions between divalent cations and dopamine for the new dopamine aptamer.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Chuanzhen Zhao, Qingzhou Liu, Kevin M. Cheung, Wenfei Liu, Qing Yang, Xiaobin Xu, Tianxing Man, Paul S. Weiss, Chongwu Zhou, Anne M. Andrews
Summary: Wafer-scale nanoribbon field-effect transistor (FET) biosensors fabricated by straightforward top-down processes are demonstrated as sensing platforms with high sensitivity to a broad range of biological targets. Large-area, uniform In2O3 nanoribbon FETs show better detection sensitivities for ions, small molecules, and oligonucleotides due to their higher surface-to-volume ratios.
Article
Biochemical Research Methods
Cameron S. Movassaghi, Katie A. Perrotta, Hongyan Yang, Rahul Iyer, Xinyi Cheng, Merel Dagher, Miguel Alcaniz Fillol, Anne M. Andrews
Summary: This study introduces a proof-of-concept for rapid pulse voltammetry coupled with partial least squares regression (RPV-PLSR), which successfully monitored basal and stimulated levels of dopamine and serotonin in the brain, demonstrating better differentiation and quantification compared to other techniques.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Immunology
Tao Jiang, Syamil Yakin, Jennifer Crocker, Baldwin M. Way
Summary: This study found that the perception of being able to provide support moderated the relationship between positive social relationships and systemic inflammation, indicating that positive social relationships are associated with lower inflammation levels only for individuals who believe they can provide more support in those relationships. Furthermore, the moderating effects of perceived support-giving may vary by gender, being significant only in women based on preliminary evidence.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Psychology, Social
David S. Lee, Tao Jiang, Jennifer Crocker, Baldwin M. Way
Summary: Social media use is positively correlated with higher levels of chronic inflammation, more somatic symptoms, and more visits to the doctor or health centers for an illness. This correlation persists even after controlling for other factors. Therefore, further research is needed to explore the relationship between social media use and physical health.
CYBERPSYCHOLOGY BEHAVIOR AND SOCIAL NETWORKING
(2022)
Article
Biochemistry & Molecular Biology
Merel Dagher, Katie A. Perrotta, Sara A. Erwin, Ayaka Hachisuka, Rahul Iyer, Sotiris C. Masmanidis, Hongyan Yang, Anne M. Andrews
Summary: Targeting neurons with light-driven opsins is a commonly used approach to study cell-specific responses. In this study, the activation of dopamine neurons resulted in the release of dopamine and serotonin in the striatum, suggesting a potential interaction between these two neurotransmitters.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Yen-Ping Chang, Baldwin M. Way, Paschal Sheeran, Laura E. Kurtz, Donald H. Baucom, Sara B. Algoe
Summary: Close social connections have a positive impact on mental and physical health, and can contribute to longevity. Expressing gratitude may play a key role in strengthening close bonds. This study provides the first evidence that a brief and low-cost behavioral technique can increase the amount of time couples spend expressing gratitude to each other in everyday life. The effect is mediated by the change in expressed gratitude.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Tatum A. Jolink, Baldwin M. Way, Ayana Younge, Christopher Oveis, Sara B. Algoe
Summary: This study demonstrates that spending more time with a romantic partner is associated with lower levels of inflammation, independent of social relationship quality and other factors. These findings provide a new perspective on the link between high-quality relationships and physical health in adults.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
Annelise A. Madison, Baldwin Way, Kyle G. Ratner, Megan Renna, Rebecca Andridge, Juan Peng, M. Rosie Shrout, John Sheridan, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Jeffrey B. VanDeusen, Nicole O. Williams, Sagar D. Sardesai, Anne M. Noonan, Raquel E. Reinbolt, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Janice K. Kiecolt-Glaser
Summary: This study examined whether a typhoid vaccine would increase social disconnection and avoidance behavior, and found that mild inflammatory stimuli did not affect social processes.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Chemistry, Multidisciplinary
Chuanzhen Zhao, Tianxing Man, Yan Cao, Paul S. Weiss, Harold G. Monbouquette, Anne M. Andrews
Summary: Monitoring neurochemical signaling is crucial for understanding brain function. This study developed flexible and implantable neuroprobes with aptamer-FET biosensors, which showed improved sensitivity and reduced tissue damage. These probes successfully detected serotonin at femtomolar concentrations. This research provides an important tool for studying brain function.
Review
Chemistry, Multidisciplinary
Yifei Luo, Mohammad Reza Abidian, Jong-Hyun Ahn, Deji Akinwande, Anne M. Andrews, Markus Antonietti, Zhenan Bao, Magnus Berggren, Christopher A. Berkey, Christopher John Bettinger, Jun Chen, Peng Chen, Wenlong Cheng, Xu Cheng, Seon-Jin Choi, Alex Chortos, Canan Dagdeviren, Reinhold H. Dauskardt, Chong-an Di, Michael D. Dickey, Xiangfeng Duan, Antonio Facchetti, Zhiyong Fan, Yin Fang, Jianyou Feng, Xue Feng, Huajian Gao, Wei Gao, Xiwen Gong, Chuan Fei Guo, Xiaojun Guo, Martin C. Hartel, Zihan He, John S. Ho, Youfan Hu, Qiyao Huang, Yu Huang, Fengwei Huo, Muhammad M. Hussain, Ali Javey, Unyong Jeong, Chen Jiang, Xingyu Jiang, Jiheong Kang, Daniil Karnaushenko, Ali Khademhosseini, Dae-Hyeong Kim, Il-Doo Kim, Dmitry Kireev, Lingxuan Kong, Chengkuo Lee, Nae-Eung Lee, Pooi See Lee, Tae-Woo Lee, Fengyu Li, Jinxing Li, Cuiyuan Liang, Chwee Teck Lim, Yuanjing Lin, Darren J. Lipomi, Jia Liu, Kai Liu, Nan Liu, Ren Liu, Yuxin Liu, Yuxuan Liu, Zhiyuan Liu, Zhuangjian Liu, Xian Jun Loh, Nanshu Lu, Zhisheng Lv, Shlomo Magdassi, George G. Malliaras, Naoji Matsuhisa, Arokia Nathan, Simiao Niu, Jieming Pan, Changhyun Pang, Qibing Pei, Huisheng Peng, Dianpeng Qi, Huaying Ren, John A. Rogers, Aaron Rowe, Oliver G. Schmidt, Tsuyoshi Sekitani, Dae-Gyo Seo, Guozhen Shen, Xing Sheng, Qiongfeng Shi, Takao Someya, Yanlin Song, Eleni Stavrinidou, Meng Su, Xuemei Sun, Kuniharu Takei, Xiao-Ming Tao, Benjamin C. K. Tee, Aaron Voon-Yew Thean, Tran Quang Trung, Changjin Wan, Huiliang Wang, Joseph Wang, Ming Wang, Sihong Wang, Ting Wang, Zhong Lin Wang, Paul S. Weiss, Hanqi Wen, Sheng Xu, Tailin Xu, Hongping Yan, Xuzhou Yan, Hui Yang, Le Yang, Shuaijian Yang, Lan Yin, Cunjiang Yu, Guihua Yu, Jing Yu, Shu-Hong Yu, Xinge Yu, Evgeny Zamburg, Haixia Zhang, Xiangyu Zhang, Xiaosheng Zhang, Xueji Zhang, Yihui Zhang, Yu Zhang, Siyuan Zhao, Xuanhe Zhao, Yuanjin Zheng, Yu-Qing Zheng, Zijian Zheng, Tao Zhou, Bowen Zhu, Ming Zhu, Rong Zhu, Yangzhi Zhu, Yong Zhu, Guijin Zou, Xiaodong Chen
Summary: Humans are increasingly relying on flexible sensors to address challenges and improve quality of life in the digital and big data era. However, the market adoption of flexible sensors is still limited despite advancements in research. In this paper, we identify the bottlenecks hindering the maturation of flexible sensors and propose potential solutions to expedite their deployment and commercialization.
Article
Immunology
David S. Lee, Tao Jiang, Jennifer Crocker, Baldwin M. Way
Summary: Drawing on recent evidence, this research proposes that inflammation may be associated with more social media use. In a nationally representative sample, Study 1 found a positive association between CRP and the amount of social media use by middle-aged adults. Study 2 showed that among college students, CRP was prospectively associated with more social media use 6 weeks later.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Endocrinology & Metabolism
Christopher R. Browning, Jodi L. Ford, Jake Tarrence, Darlene A. Kertes, Rita H. Pickler, Baldwin M. Way, Catherine A. Calder
Summary: By examining real-time perceptions of safety in everyday routines, this study sheds light on the sources of racial differences in chronic stress among adolescents. We found that perceived unsafety was associated with higher hair cortisol concentration for Black youth, but not for White youth.
PSYCHONEUROENDOCRINOLOGY
(2023)
Meeting Abstract
Psychiatry
Kendra Wilson, Lexi Keaveney, Russell Fazio, Baldwin Way
PSYCHOSOMATIC MEDICINE
(2022)
Meeting Abstract
Psychiatry
Tatum A. Jolink, Baldwin Way, Ayana Younge, Chris Oveis, Sara B. Algoe
PSYCHOSOMATIC MEDICINE
(2022)