Article
Physiology
Nada Starcevic Eizmarevic, Miljenko Kapovic, Dobrica Roncevic, Smiljana Ristic
Summary: Research suggests that the CCR5-Delta 32 allele may be protective against COVID-19 infection and severity, but further validation is needed.
PHYSIOLOGICAL RESEARCH
(2021)
Article
Oncology
Yuan Zhuang, Xiaomei Zhao, Baoying Yuan, Zhaochong Zeng, Yixing Chen
Summary: The study showed that the CCR5 antagonist MVC can induce macrophage polarization towards the M1 phenotype by blocking the CCL5-CCR5 signaling pathway, thereby enhancing the sensitivity and apoptosis of human hepatoma cells to radiation.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Gastroenterology & Hepatology
Jiaqi Yang, David Sontag, Yuewen Gong, Gerald Y. Minuk
Summary: The study found different CCR expression profiles in intrahepatic and extrahepatic cholangiocarcinoma cells, with CCR5 antagonists inhibiting tumor cell aggressiveness and CCR5 agonists increasing cell proliferation and invasion in specific cell types.
ANNALS OF HEPATOLOGY
(2021)
Article
Immunology
Bashar Alkhatib, Mary Jabari, Shymaa Bilasy, Husni Abdul-Rahman, Kamal Sandhu, Stephen Lai, Ghalib Alkhatib
Summary: We analyzed a case of a same-gender couple where one partner had HIV while the other partner was HIV-negative. The HIV-negative partner had a mutation in their CCR5 gene, known as CCR5 Delta 32, and a C20S missense mutation. Their cells showed resistance to HIV infection and had no response to a specific chemokine. Although CCR5-specific RNA was present in the HIV-negative partner's cells, CCR5 protein was not detectable. The combination of CCR5 Delta 32 and C20S mutations impaired CCR5 function and conferred resistance to HIV-1.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Bruce K. Patterson, Ram Yogendra, Jose Guevara-Coto, Rodrigo A. Mora-Rodriguez, Eric Osgood, John Bream, Purvi Parikh, Mark Kreimer, Devon Jeffers, Cedric Rutland, Gary Kaplan, Michael Zgoda
Summary: Post-acute sequelae of COVID (PASC), also known as long COVID, is a debilitating complication of SARS-CoV-2 infection. Recent research suggests that targeting certain receptors using drugs like maraviroc and pravastatin may improve symptoms and restore immune dysregulation in PASC. A pilot study with 18 participants showed significant clinical improvement in neurological, autonomic, respiratory, cardiac, and fatigue symptoms after 6 to 12 weeks of treatment with maraviroc and pravastatin.
FRONTIERS IN MEDICINE
(2023)
Article
Allergy
Marc Gauthier, Sagar Laxman Kale, Timothy B. Oriss, Kathryn Scholl, Sudipta Das, Huijuan Yuan, Sanmei Hu, Jie Chen, Matthew Camiolo, Prabir Ray, Sally Wenzel, Anuradha Ray
Summary: This study investigated the role of chemotactic receptors CXCR3 and CCR5 in establishing type 1 inflammation in severe asthma. The results showed a strong correlation between CXCR3, CCR5, and IFN-γ expression. Inhibiting the CCR5 pathway with maraviroc reduced airway hyperreactivity. Targeting this pathway may be a novel approach for improving lung function in individuals with type 1-high asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Stephanie M. Matt, Emily A. Nickoloff-Bybel, Yi Rong, Kaitlyn Runner, Hannah Johnson, Margaret H. O'Connor, Elias K. Haddad, Peter J. Gaskill
Summary: The study suggests that drug-induced increases in central nervous system dopamine levels may be a common mechanism by which distinct addictive substances alter neuroHIV. Dopamine can affect HIV replication and alter the conformation of immune cells, highlighting the importance of dopamine in the development of neuroHIV.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Stefanie N. Bernas, Henning Baldauf, Sarah Wendler, Falk Heidenreich, Vinzenz Lange, Jan A. Hofmann, Juergen Sauter, Alexander H. Schmidt, Johannes Schetelig
Summary: The study found that the CCR5A32 genotype is not significantly associated with the risk of contracting SARS-CoV-2 and severe COVID-19 among stem cell donors.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Biotechnology & Applied Microbiology
Renlun Huang, Lang Guo, Menghan Gao, Jing Li, Songtao Xiang
Summary: Prostate cancer (PCa) is the most common cancer of urologic neoplasms, and the CCL5/CCR5 axis plays a significant role in its development, but challenges remain in precision oncology.
ONCOTARGETS AND THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Zhifu Wang, Danyi Zheng, Ye Sing Tan, Qiang Yuan, Fang Yuan, Su-Chun Zhang
Summary: A chemical cocktail consisting of fibrinogen and CCR5 antagonist maraviroc supports the survival and maturation of neural precursors that are transplanted into the ischemic stroke cavity by blocking the inflammatory cascade, enabling the reconstitution of the damaged central nervous system by grafted neural cells.
Article
Biochemistry & Molecular Biology
Alyona Sorokina, Alexander Artyuhov, Alexandra Goltsova, Erdem Dashinimaev
Summary: The CCR5 receptor plays a role in HIV infection, and the CCR5 & UDelta;32 mutation could be a potential cure for HIV. This study developed a system using CRISPR/Cas9 and ddPCR to accurately measure the content of cells with the CCR5 & UDelta;32 mutation.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Yenisleidys Martinez-Montesinos, Vivian Kouri-Cordella, Lissette Perez-Santos, Rui Han, Yanet Pintos-Saavedra, Yoan Aleman-Campos, Yudira Soto-Brito, Yoanna Banos-Morales, Yaniris Caturla-Fernandez
Summary: The study found an association between CRF19_cpx and X4 and R5X4 tropic viruses. There is wide diversity in V3 sequences among different HIV-1 subtypes circulating in Cuba.
Article
Clinical Neurology
Jeremy Molad, Hen Hallevi, Estelle Seyman, Ofer Rotschild, Natan M. Bornstein, Oren Tene, Nir Giladi, Jeffrey M. Hausdorff, Anat Mirelman, Einor Ben Assayag
Summary: This study found significant associations between gait measurements and the CCR5-delta 32 loss-of-function mutation among stroke survivors, suggesting that genetic predisposition may predict long-term gait function after ischemic stroke.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Microbiology
Xiao L. Chang, Jason S. Reed, Gabriela M. Webb, Helen L. Wu, Jimmy Le, Katherine B. Bateman, Justin M. Greene, Cleiton Pessoa, Courtney Waytashek, Whitney C. Weber, Joseph Hwang, Miranda Fischer, Cassandra Moats, Oriene Shiel, Rachele M. Bochart, Hugh Crank, Don Siess, Travis Giobbi, Jeffrey Torgerson, Rebecca Agnor, Lina Gao, Kush Dhody, Jacob P. Lalezari, Ivo Sah Bandar, Alnor M. Carnate, Alina S. Pang, Michael J. Corley, Scott Kelly, Nader Pourhassan, Jeremy Smedley, Benjamin N. Bimber, Scott G. Hansen, Lishomwa C. Ndhlovu, Jonah B. Sacha
Summary: The CCR5-specific antibody Leronlimab has shown to be a safe and effective immunotherapy for suppressing HIV replication without significant side effects. It can fully occupy CCR5 receptors on CD4+ T cells and monocytes, leading to long-term virologic suppression in both humans and macaques.
Article
Chemistry, Multidisciplinary
Jordan M. Mattheisen, Chris Limberakis, Roger B. Ruggeri, Matthew S. Dowling, Christopher W. am Ende, Emilie Ceraudo, Thomas Huber, Christopher L. McClendon, Thomas P. Sakmar
Summary: We developed a strategy to covalently tether drug fragments adjacent to allosteric sites in GPCRs to enhance their potency and enable fragment-based drug screening in cell-based systems.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)