Article
Multidisciplinary Sciences
Elaina Kaufman, Tyler Williamson, Marie-Helene Mayrand, Ann N. Burchell, Marina Klein, Louise Charest, Sophie Rodrigues-Coutlee, Francois Coutlee, Alexandra de Pokomandy
Summary: In this study, multivariable logistic regression analysis was used to analyze the baseline data of anal HPV 16 infection, and it was found that current smoking, nadir CD4 count, prevalent cervical HPV 16 infection, and anogenital herpes in the previous 6 months were associated with prevalent anal HPV 16 infection.
Article
Multidisciplinary Sciences
Erin M. Siegel, Abidemi Ajidahun, Anders Berglund, Whitney Guerrero, Steven Eschrich, Ryan M. Putney, Anthony Magliocco, Bridget Riggs, Kathryn Winter, Jeff P. Simko, Jaffer A. Ajani, Chandan Guha, Gordon S. Okawara, Ibrahim Abdalla, Mark J. Becker, Joseph F. Pizzolato, Christopher H. Crane, Kevin D. Brown, David Shibata
Summary: HPV infection leads to changes in host gene methylation, contributing to neoplastic progression of HPV-associated cancers. This study identified genome-wide methylation changes in anal and cervical cancer, as well as high-grade pre-neoplastic lesions, and found common overlapping hypermethylated genes in the progression of both cancers.
Article
Oncology
Mette T. Faber, Kirsten Frederiksen, Joel M. Palefsky, Susanne K. Kjaer
Summary: This study found that individuals with autoimmune diseases or genital warts, as well as HIV-infected individuals, were more likely to progress to ASCC among those diagnosed with AIN3. These associations may be related to the interplay between HPV infection and immunosuppression.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Letter
Medicine, General & Internal
Paolo Goffredo, Nicholas D. Klemen, Imran Hassan
Summary: The study confirmed that high-resolution anoscopy-guided periodic ablation of HSIL can reduce the risk of anal cancer in HIV-positive patients, but the reduction is small and of debatable clinical relevance.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Letter
Medicine, General & Internal
Paolo Goffredo, Nicholas D. Klemen, Imran Hassan
Summary: The study confirms that high-resolution anoscopy-guided periodic ablation of HSIL can reduce the risk of anal cancer in HIV-positive patients, although the magnitude of risk reduction is low.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Marta del Pino, Isabel Matas, Pilar Carrillo, Cristina Marti, Ariel Glickman, Nuria Carreras-Dieguez, Lorena Marimon, Adela Saco, Natalia Rakislova, Aureli Torne, Jaume Ordi
Summary: Women with anal HPV infection treated for HSIL/CIN2-3 should be re-tested for anal HPV after treatment. Those who have persisting anal HPV infection after treatment are at high risk of developing HSIL/AIN and may benefit from anal exploration. Additionally, women with anal HPV infection treated for HSIL/CIN might have a higher risk of recurrent cervical HPV infection.
Article
Medicine, General & Internal
J. M. Palefsky, J. Y. Lee, N. Jay, S. E. Goldstone, T. M. Darragh, H. A. Dunlevy, I. Rosa-Cunha, A. Arons, J. C. Pugliese, D. Vena, J. A. Sparano, T. J. Wilkin, G. Bucher, E. A. Stier, M. Tirado Gomez, L. Flowers, L. F. Barroso, R. T. Mitsuyasu, S. Y. Lensing, J. Logan, D. M. Aboulafia, J. T. Schouten, J. de la Ossa, R. Levine, J. D. Korman, M. Hagensee, T. M. Atkinson, M. H. Einstein, B. M. Cracchiolo, D. Wiley, G. B. Ellsworth, C. Brickman, J. M. Berry-Lawhorn
Summary: Treatment for anal HSIL can significantly reduce the risk of anal cancer in persons living with HIV.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jihoon Kim, Halim Jo, Min Chul Ha, Hyunil Kim, Jung Kuk Lee, Jae Hun Han, San-Hui Lee, Dae Ryong Kang, Su Young Kim, Hyun-Soo Kim, Hee Man Kim
Summary: This study investigated the association between ulcerative colitis (UC) and uterine cervical cancer in South Korean women using health insurance claims data. The results showed that UC patients had a higher risk of developing cervical cancer, especially among elderly patients and those with low socioeconomic status. Regular cervical cancer screening is recommended for elderly patients recently diagnosed with UC.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Racheal S. Dube Mandishora, Trine B. Rounge, Megan Fitzpatrick, Irene Kraus Christiansen, Ole Herman Ambur, Sonja Lagstroem, Babill Stray-Pedersen, Massimo Tommasino, Joel Palefsky, Zvavahera M. Chirenje
Summary: This study found moderate agreement between self-collected anal swabs and clinician-collected anal swabs in HPV genotyping, with no significant difference in the proportion of genotypes detected by either method. Self-collected anal swabs may be used as an alternative to clinician-collected anal swabs for HPV genotyping.
Article
Obstetrics & Gynecology
Belen Lopez-Cavanillas, Cristina G. Benitez, Maria Serrano, Elena Sendagorta, Alicia Hernandez, Jose L. Bartha
Summary: The study found that there is a certain association between anal HPV infection and abnormal anal cytology with high-grade cervical intraepithelial neoplasia, but there was no statistically significant difference compared to women with CIN 1 or no cervical dysplasia. Apart from HPV infection, immunosuppression, cervical HPV infection, and being older than 40 were also associated with anomalous anal results.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Oncology
Mari Nyga, Birgit Engesaeter, Philip E. Castle, Jannicke Mohr Berland, Maj Liv Eide, Ole Erik Iversen, Christine Monceyron Jonassen, Irene Kraus Christiansen, Olav Karsten Vintermyr, Ameli Trope
Summary: This study compared the effectiveness of HPV-based screening protocol and liquid-based cytology (LBC) screening protocol in detecting cervical intraepithelial neoplasia (CIN) and cancer. The results showed that the HPV-based screening protocol was more effective in detecting CIN2, CIN3, and cancer than the LBC screening protocol. The effectiveness of both protocols varied with age, with better outcomes observed in women under 50 years old.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Review
Gastroenterology & Hepatology
Andreia Albuquerque, Mayura Nathan, Carmelina Cappello, Mario Dinis-Ribeiro
Summary: Anal squamous cell carcinoma, associated with anal HPV infection, is increasing in incidence and common in specific population groups. Screening aims to detect precancerous lesions for prevention, with various treatment options available for high-grade lesions. Gastroenterologists should be aware of these conditions for early detection in high-risk patients.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Pathology
Amanda M. Hopp, Andrii Puzyrenko, Tamara Giorgadze
Summary: Incidence of anal cancer has been increasing over the past decade, predominantly affecting women in the general population. Although pathophysiology is similar to cervical cancer, well-defined screening guidelines are lacking. Anal cytology, HPV testing, digital anorectal exam, and anoscopy are important components of screening, along with management guidelines from studies like the ANCHOR trial.
Article
Obstetrics & Gynecology
Afsaneh Tehranian, Akram Ghahghaei-Nezamabadi, Akram Seifollahi, Parisa Mansouri, Arezoo Maleki-Hajiagha, Reyhaneh Aghajani
Summary: This study found no correlation between abnormal cervical cytology, dysplasia, or cervical high-risk HPV with anal abnormal cytology.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Public, Environmental & Occupational Health
Anna-Barbara Moscicki, Charlene Chang, Sitaram Vangala, Xinkai Zhou, David A. Elashoff, Christine Dehlendorf, George F. Sawaya, Miriam Kuppermann, Ysabel Duron, Fred L. Wyand, Sandy K. Navarro, Heike Thiel de Bocanegra
Summary: This study aimed to determine whether using a provider mobile phone application and a patient educational tool could promote adherence to guidelines for cervical cancer screening and management of abnormal cytology in young women. Results showed that the intervention did not have a significant effect on 18-month Pap and colposcopy rates in the regression model, but the sensitivity analysis for the patient educational tool was encouraging.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)