Article
Oncology
Marta del Pino, Isabel Matas, Pilar Carrillo, Cristina Marti, Ariel Glickman, Nuria Carreras-Dieguez, Lorena Marimon, Adela Saco, Natalia Rakislova, Aureli Torne, Jaume Ordi
Summary: Women with anal HPV infection treated for HSIL/CIN2-3 should be re-tested for anal HPV after treatment. Those who have persisting anal HPV infection after treatment are at high risk of developing HSIL/AIN and may benefit from anal exploration. Additionally, women with anal HPV infection treated for HSIL/CIN might have a higher risk of recurrent cervical HPV infection.
Article
Oncology
Huei-Jean Huang, Hsiu-Jung Tung, Lan-Yan Yang, Angel Chao, Yun-Hsin Tang, Hung-Hsueh Chou, Wei-Yang Chang, Ren-Chin Wu, Chu-Chun Huang, Chiao-Yun Lin, Min-Jie Liao, Wei-Chun Chen, Cheng-Tao Lin, Min-Yu Chen, Kuan-Gen Huang, Chin-Jung Wang, Ting-Chang Chang, Chyong-Huey Lai
Summary: This observational study investigated the long-term outcomes and HPV genotype changes after conization for high-grade cervical intraepithelial neoplasia (HG-CIN). Results showed that active surveillance may reduce the severity of progression to cancer, and a majority of patients with recurrent CIN2+ had persistent type-specific HPV infections. Effective therapeutic vaccines for such cases are still needed.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Infectious Diseases
Hong-Fang Zhi, Liu-Feng Yang, Jing Ge, Xuan-Tao Yang
Summary: This study analyzed the status of human papillomavirus (HPV) infections in women in Yunnan, China and their correlation with the grade of cervical intraepithelial neoplasia (CIN). The study found that HPV infection in Yunnan was dominated by single infection and high-risk HPV types. Patients aged 30 to 45 years had a higher incidence of high-grade squamous intraepithelial lesions (HSIL), and the most common high-risk HPV subtypes were HPV16, HPV58, and HPV52.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Oncology
Christoph Wohlmuth, Zeina Ghorab, Michael Shier, Jill Tinmouth, Irving E. Salit, Allan Covens, Liying Zhang, Danielle Vicus
Summary: This study found a high prevalence of abnormal anal cytology and HPV positivity in women aged >= 40 years with a history of high-grade cervical SIL or cancer. Older age and smoking were significant risk factors for abnormal anal cytology. High-grade AIN had a higher prevalence in this population, suggesting the consideration of screening for anal cancer in these patients. Further research is needed to determine the optimal screening approach.
CANCER CYTOPATHOLOGY
(2021)
Article
Immunology
Ramon P. van der Zee, Olivier Richel, Carel J. M. van Noesel, Iuliana Ciocanea-Teodorescu, Annina P. van Splunter, Timo J. Ter Braak, Mayura Nathan, Tamzin Cuming, Michael Sheaff, Alexander Kreuter, Chris J. L. M. Meijer, Wim G. Quint, Henry J. C. de Vries, Jan M. Prins, Renske D. M. Steenbergen
Summary: This study validated the accuracy of 5 methylation markers for the detection and cancer risk stratification of HGAIN. High methylation levels in HGAIN were associated with progression to cancer. These markers provide a promising tool to identify HGAIN in need of treatment.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Oncology
Matejka Rebolj, Christopher S. Mathews, Francesca Pesola, Alejandra Castanon, Henry Kitchener
Summary: International cervical screening guidelines suggest that high-risk human papillomavirus (HR-HPV) testing is more effective than liquid-based cytology (LBC) for diagnosing cervical cancer in women aged 24 to 29, as it not only accelerates cancer diagnosis, but also increases the detection of CIN2/3.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Erika Hurtado-Salgado, Luz Cardenas-Cardenas, Jorge Salmeron, Rufino Luna-Gordillo, Eduardo Ortiz-Panozo, Betania Allen-Leigh, Nenetzen Saavedra-Lara, Eduardo L. Franco, Eduardo Lazcano-Ponce
Summary: This study analyzed screening data from Mexico's public cervical cancer prevention program from 2010 to 2015, and found that hrHPV testing with cytological triage can detect twice as many CIN2+ cases compared to screening using cytology alone in women aged 35 to 64.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Robine Donken, Dirk van Niekerk, Jeremy Hamm, John J. Spinelli, Laurie Smith, Manish Sadarangani, Arianne Albert, Deborah Money, Simon Dobson, Dianne Miller, Marette Lee, Sheona Mitchell-Foster, Mel Krajden, Monika Naus, Gina Ogilvie
Summary: The HPV vaccination program in British Columbia, Canada has led to a significant decrease in CIN 2 and 3 rates among women aged 16-23, but no decline was observed in women aged 24-28. This suggests a successful population impact of the school-based HPV vaccination program.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Fangbin Song, Peisha Yan, Xia Huang, Chun Wang, Hui Du, Xinfeng Qu, Ruifang Wu
Summary: This study aimed to investigate the risk of HPV genotyping for cervical precancer and cancer and assess its effects on genotype-specific screening and HPV vaccine.
Article
Obstetrics & Gynecology
Afsaneh Tehranian, Akram Ghahghaei-Nezamabadi, Akram Seifollahi, Parisa Mansouri, Arezoo Maleki-Hajiagha, Reyhaneh Aghajani
Summary: This study found no correlation between abnormal cervical cytology, dysplasia, or cervical high-risk HPV with anal abnormal cytology.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Public, Environmental & Occupational Health
Jaime M. Kiff, Madisen Cotter, Elizabeth G. Munro, Molly E. Leonard, Terry K. Morgan, Amanda S. Bruegl
Summary: This study suggests that hrHPV testing may be more accurate than co-testing in postmenopausal women, and cytology does not provide additional clinical value in this population. Women with persistent hrHPV were more likely to develop CIN2+ compared to those who cleared the virus, but no specific risk factors for persistence were identified in the study.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Philip E. Castle, Brian Befano, Mark Schiffman, Nicolas Wentzensen, Thomas Lorey, Nancy Poitras, Marianne Hyer, Li C. Cheung
Summary: This study compared the risks of cervical intraepithelial neoplasia grade 2 (CIN2) or more severe diagnoses (CIN2+) between women living with HIV (WLWH) and women not known to have HIV (HIV[-]) following cervical cancer screening. WLWH were more likely to test HPV positive and have abnormal cytology compared to HIV[-] women. The results suggest that both populations could be managed similarly once the screening results are known.
PREVENTIVE MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Andreia Albuquerque, Mayura Nathan, Carmelina Cappello, Mario Dinis-Ribeiro
Summary: Anal squamous cell carcinoma, associated with anal HPV infection, is increasing in incidence and common in specific population groups. Screening aims to detect precancerous lesions for prevention, with various treatment options available for high-grade lesions. Gastroenterologists should be aware of these conditions for early detection in high-risk patients.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Microbiology
Kaori Okayama, Toshiyuki Sasagawa, Koji Teruya, Mizue Oda, Masahiko Fujii, Hirokazu Kimura, Mitsuaki Okodo
Summary: This study found an association between HPV genotypes and MNCs, high-risk HPV genotypes may be related to atypical changes in MNC morphology, and MNCs may predict squamous intraepithelial lesions.
Article
Microbiology
Barbara Gardella, Mattia Dominoni, Cecilia Sosso, Anna Arrigo, Andrea Gritti, Stefania Cesari, Giacomo Fiandrino, Arsenio Spinillo
Summary: A study analyzed the time trends prevalence of HPV genotypes among 5807 subjects with abnormal pap-smears and/or cervical intraepithelial neoplasia over a 15-year period. Results showed a decrease in HPV16 rates in CIN1 biopsies and an increase of HR-HPV types unrelated to nonavalent vaccine in CIN1 lesions. Additionally, HPV 18, 31, and 52 rates decreased in CIN2+ patients.