Article
Biology
Babak J. Mehrara, Hyeung Ju Park, Raghu P. Kataru, Jacqueline Bromberg, Michelle Coriddi, Jung Eun Baik, Jinyeon Shin, Claire Li, Michele R. Cavalli, Elizabeth M. Encarnacion, Meghan Lee, Kimberly J. Van Zee, Elyn Riedel, Joseph H. Dayan
Summary: The study aimed to examine the effect of inhibiting Th2 inflammation in lymphedema by using QBX258, a combination of IL4/13 neutralizing antibodies, and found that it improved quality of life and reduced pathological skin changes in women with breast cancer-related lymphedema. Treatment with QBX258 showed improvements in skin stiffness and quality of life measurements, particularly in physical and social aspects, with histological evidence of decreased epidermal changes and cytokine expression in lymphedematous skin.
Article
Medicine, General & Internal
Johnson Chia-Shen Yang, Lien-Hung Huang, Shao-Chun Wu, Pao-Jen Kuo, Yi-Chan Wu, Chia-Jung Wu, Chia-Wei Lin, Pei-Yu Tsai, Ching-Hua Hsieh
Summary: This study revealed that specific oxidative stress markers and antioxidant capacity in the serum of lymphedema patients can change following lymphaticovenous anastomosis (LVA) surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Melisa D. Granoff, Jaime A. Pardo, Anna Rose Johnson, Aaron Fleishman, Elizabeth Tillotson, Sarah Thomson, Bernard T. Lee, Dhruv Singhal
Summary: This study provides detailed information about the anatomy of three forearm lymphatic channels and their connections to the upper arm in adults without lymphatic disease, which is important for individuals performing procedures on the upper extremities.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hye Ok Kim, Kyong-Je Woo, Bom Sahn Kim, Seo Young Kang, Byung Seok Moon, Hai-Jeon Yoon
Summary: This study evaluated the utility of lymphoscintigraphy in predicting outcomes of lymphaticovenous anastomosis (LVA) for extremity lymphedema. The results showed that the extent of dermal backflow and lymphatic flow patterns were significantly associated with clinical outcomes after LVA surgery. Furthermore, dermal backflow and lymphatic flow patterns were identified as independent predictors of circumferential reduction rate after LVA surgery for extremity lymphedema.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Surgery
Takumi Yamamoto, Toko Miyazaki, Hayahito Sakai, Reiko Tsukuura, Nana Yamamoto
Summary: This study evaluated the feasibility of a new lymphaticovenous shunt method for the progression of upper extremity lymphedema in breast cancer survivors. The results showed that the dermal-adipose lymphatic flap venous wrapping procedure was effective in treating lymphedema progression and improving patients' quality of life.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2023)
Article
Surgery
Wanchalerm Chungsiriwattana, Natthapong Kongkunnavat, Sirichai Kamnerdnakta, Akitatsu Hayashi, Warangkana Tonaree
Summary: Immediate lymphaticovenous anastomosis (LVA) did not reduce the incidence of lymphedema in lower extremity skin cancer patients. It was associated with lower overall survival and an increase in tumor recurrence and metastasis.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Akitatsu Hayashi, Giuseppe Visconti, Chia-Shen (Johnson) Yang, Nobuko Hayashi, Hidehiko Yoshimatsu
Summary: This study investigated the efficacy of lymphaticovenular anastomosis (LVA) on the posterior side of the lower leg for the treatment of primary lymphedema. The results showed that performing LVA on the posterior side in addition to the anterior and medial sides resulted in further improvement of lower extremity lymphedema with a reduced number of anastomoses.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Johnson Chia-Shen Yang, Shao-Chun Wu, Akitatsu Hayashi, Wei-Che Lin, Yu-Ming Wang, Sheng-Dean Luo, Min-Hsien Chiang, Ching-Hua Hsieh
Summary: This study established the minimum size of functional lymphatic vessels for lymphaticovenous anastomosis as 0.50 mm. The post-operative volume reduction was correlated with the number of anastomosed lymphatic vessels, and the use of 0.50 mm lymphatic vessels for anastomosis enhanced post-operative outcomes.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Surgery
Maureen Beederman, Rebecca M. Garza, Shailesh Agarwal, David W. Chang
Summary: The long-term impact of VLNT and LVB surgeries on secondary lymphedema patients was examined in this study. The results showed that most UEL patients and some LEL patients experienced a reduction in affected limb volume after surgery. UEL patients had a more substantial reduction in limb volume differential compared to LEL patients.
Article
Medicine, General & Internal
Johnson Chia-Shen Yang, Shao-Chun Wu, Akitatsu Hayashi, Wei-Che Lin, Gong-Kai Huang, Pei-Yu Tsai, Peng-Chen Chien, Ching-Hua Hsieh
Summary: This study suggests that lymphaticovenous anastomosis (LVA) can be considered as a secondary procedure for post-vascularized lymph node flap transfer (VLNT) patients seeking further improvement in lymphedema treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Yara W. Kassamani, Cheryl L. Brunelle, Tessa C. Gillespie, Madison C. Bernstein, Loryn K. Bucci, Tracy Nassif, Alphonse G. Taghian
Summary: With advancements in breast cancer treatments, the focus is now shifting towards post-treatment complications like BCRL, with emphasis on early detection and intervention for improved prognosis. The lack of consensus on diagnostic criteria for BCRL has led to variations in practices across institutions, highlighting the need for universal standardized diagnostic processes.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Rehabilitation
Linda Koehler, Amanda Day, David Hunter, Anne Blaes, Tufia Haddad, Ryan Shanley
Summary: Axillary web syndrome (AWS) is associated with reduced shoulder range of motion in the early postoperative period and can persist for 5 years after breast cancer surgery. Long-term physical issues are apparent after breast cancer surgery regardless of the presence of AWS.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Biophysics
Emine Baran, Taha Ibrahim Yildiz, Ceren Gursen, Esra Uzelpasaci, Serap Ozgul, Irem Duzgun, Turkan Akbayrak
Summary: This study found an association between breast cancer-related lymphedema and impaired shoulder girdle kinematics and decreased upper extremity function, with the severe lymphedema group experiencing more significant effects on scapular movements and shoulder abduction range of motion.
JOURNAL OF BIOMECHANICS
(2021)
Article
Surgery
Yasunori Hattori, Kota Hayashi, Sotetsu Sakamoto, Kazuteru Doi
Summary: A new index (UVR) was developed for body type-corrected volume evaluation of upper-extremity lymphedema. The study found that there was no relationship between UVR and BMI in adult women, suggesting the potential for better evaluation of upper-extremity lymphedema with this index.
ANNALS OF PLASTIC SURGERY
(2021)
Review
Oncology
Amanda Sutherland, Jamie L. Wagner, Sabrina Korentager, James Butterworth, Amanda L. Amin, Christa R. Balanoff, Amanda Hangge, Kelsey E. Larson
Summary: The study demonstrated that lymphovenous bypass (LVB) in patients with breast cancer-related lymphedema (BCRL) led to significant improvement in bioimpedance spectroscopy (BIS) measurements. Postoperative BIS showed a substantial reduction, which remained stable over time.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Cardiac & Cardiovascular Systems
Swapna Ghanta, Daniel A. Cuzzone, Jeremy S. Torrisi, Nicholas J. Albano, Walter J. Joseph, Ira L. Savetsky, Jason C. Gardenier, David Chang, Jamie C. Zampell, Babak J. Mehrara
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2015)
Article
Neurosciences
Matthew D. Nitti, Geoffrey E. Hespe, Raghu P. Kataru, Gabriela D. Garcia Nores, Ira L. Savetsky, Jeremy S. Torrisi, Jason C. Gardenier, Andrew J. Dannenberg, Babak J. Mehrara
JOURNAL OF PHYSIOLOGY-LONDON
(2016)
Article
Multidisciplinary Sciences
Jason C. Gardenier, Raghu P. Kataru, Geoffrey E. Hespe, Ira L. Savetsky, Jeremy S. Torrisi, Gabriela D. Garcia Nores, Dawit K. Jowhar, Matthew D. Nitti, Ryan C. Schofield, Dean C. Carlow, Babak J. Mehrara
NATURE COMMUNICATIONS
(2017)
Article
Dentistry, Oral Surgery & Medicine
John T. Stranix, Daniel Cuzzone, Catherine Ly, Nicole Topilow, Christopher M. Runyan, Justin Ream, Roberto L. Flores
CLEFT PALATE-CRANIOFACIAL JOURNAL
(2017)
Article
Dermatology
Gabriela D. Garcia Nores, Catherine L. Ly, Ira L. Savetsky, Raghu P. Kataru, Swapna Ghanta, Geoffrey E. Hespe, Stanley G. Rockson, Babak J. Mehrara
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Multidisciplinary Sciences
Gabriela D. Garcia Nores, Catherine L. Ly, Daniel A. Cuzzone, Raghu P. Kataru, Geoffrey E. Hespe, Jeremy S. Torrisi, Jung Ju Huang, Jason C. Gardenier, Ira L. Savetsky, Matthew D. Nitti, Jessie Z. Yu, Sonia Rehal, Babak J. Mehrara
NATURE COMMUNICATIONS
(2018)
Article
Surgery
Derek Daniel Reformat, Gabriela Garcia Nores, Gretl Lam, Daniel Cuzzone, John Bradford Hill, Horatiu Muresan, Vishal Thanik
ANNALS OF PLASTIC SURGERY
(2018)
Article
Surgery
Catherine L. Ly, Daniel A. Cuzzone, Raghu P. Kataru, Babak J. Mehrara
PLASTIC AND RECONSTRUCTIVE SURGERY
(2019)
Article
Oncology
Swapna Ghanta, Ahkeel Allen, Alicia Huff Vinyard, Rachel Berger, Jessica Aoun, Jamie Rosenkrantz Spoont, Eli Avisar
Article
Surgery
Ira L. Savetsky, Michael J. Cammarata, Rami S. Kantar, J. Rodrigo Diaz-Siso, Yash J. Avashia, Rod J. Rohrich, Pierre B. Saadeh
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2020)
Review
Surgery
Ira L. Savetsky, Alan Matarasso
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2020)
Article
Surgery
Ira L. Savetsky, Seth Z. Aschen, Ara A. Salibian, Katherine Howard, Z-Hye Lee, Spiros G. Frangos, Vishal D. Thanik
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2019)
Article
Medicine, Research & Experimental
Jason C. Gardenier, Geoffrey E. Hespe, Raghu P. Kataru, Ira L. Savetsky, Jeremy S. Torrisi, Gabriela D. Garcia Nores, Joseph J. Dayan, David Chang, Jamie Zampell, Ines Martinez-Corral, Sagrario Ortega, Babak J. Mehrara