Article
Biophysics
Simbarashe G. Chidyagwai, Madhurima Vardhan, Michael Kaplan, Reid Chamberlain, Piers Barker, Amanda Randles
Summary: This study used computational fluid dynamics simulations and surgical correction to investigate the impact of AAOCA on patient hemodynamics. The results showed that patients with AAOCA had higher TAWSS values and that coronary unroofing surgery normalized the TAWSS. These findings provide evidence for potential hemodynamic factors underlying coronary ischemia in AAOCA during exercise.
JOURNAL OF BIOMECHANICS
(2022)
Article
Physiology
John D. Horn, Michael J. Johnson, Zbigniew Starosolski, Avner Meoded, Dianna M. Milewicz, Ananth Annapragada, Shaolie S. Hossain
Summary: This study aims to assess the stroke risk in pediatric MMD patients by analyzing local hemodynamics. The findings suggest that WSR-based metrics could be predictive of future stroke risk after an initial stroke in pediatric MMD patients. It is recommended to perform patient-specific hemodynamic analysis at multiple timepoints during patient follow-up to better predict and prevent secondary strokes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Jiwen Xiong, Qi Sun, Yi Qian, Liwei Hu, Zhirong Tong, Jinfen Liu, Jinlong Liu
Summary: This study investigated the effects of preserving the PDA during MBTS procedures on blood flow dynamics. It was found that preserving the PDA competitively reduced shunt flow but increased total pulmonary perfusion, leading to significant and complicated turbulence in the pulmonary artery and increased energy loss. Therefore, preserving PDA is not recommended as it may negatively impact hemodynamics and increase the risk of heart failure.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Nimmy Thankom Philip, Srinivas Bolem, B. J. Sudhir, B. S. V. Patnaik
Summary: This study investigates the influence of morphological features and hemodynamic forces on the rupture of cerebral aneurysms. Three different shapes of aneurysms are studied: spherical, beehive, and pear-shaped. The study compares these model aneurysms with patient-specific configurations. The results show that pear-shaped aneurysms may lead to atherosclerotic lesions, while beehive-shaped aneurysms are more prone to forming secondary blebs. Spherical aneurysms exhibit a stable flow field and uniform distribution of wall stresses, indicating a hemodynamically and bio-mechanically stable condition.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Biophysics
Zijian Zhang, Jiade Zhu, Min Wu, Michael Neidlin, Wei-Tao Wu, Peng Wu
Summary: Hemodynamics play a crucial role in assessing the risk of thrombosis in atrial fibrillation patients. Patient specificity, blood rheology, and mitral valve conditions all influence the hemodynamics and thrombosis potential in the left atrial appendage. The study's findings highlight the importance of patient-specific hemodynamic simulations in understanding thrombus formation.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Engineering, Multidisciplinary
Gabriel D. Maher, Casey M. Fleeter, Daniele E. Schiavazzi, Alison L. Marsden
Summary: A novel approach utilizing convolutional neural networks is proposed to generate samples from patient-specific cardiovascular models based on clinically acquired image volumes. The method focuses on learning geometric uncertainty directly from training data and demonstrates its impact on hemodynamics for different patient-specific anatomies.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Jonas Schollenberger, Nicholas H. Osborne, Luis Hernandez-Garcia, C. Alberto Figueroa
Summary: This study presents a strategy to quantify cerebral hemodynamics in patients with CVOD using CFD and ASL. The feasibility and efficacy of this method were demonstrated through calibration and evaluation of blood flow distribution in two patients and a healthy control subject. Patient-specific CFD analysis showed advantages in assessing the hemodynamic impact of stenosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Molly Cherry, Zinedine Khatir, Amirul Khan, Malenka Bissell
Summary: Magnetic Resonance Imaging (MRI) is the gold standard for medical imaging, and 4D-Flow MRI is a modified version that provides flow data for calculating hemodynamic parameters. However, the current spatial resolution of 4D-Flow MRI is limited, which may result in inaccuracies in patient-specific Computational Fluid Dynamics (CFD) simulations.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Yunus Ahmed, Christopher Tossas-Betancourt, Pieter A. J. van Bakel, Jonathan M. Primeaux, William J. Weadock, Jimmy C. Lu, Jeffrey D. Zampi, Arash Salavitabar, C. Alberto Figueroa
Summary: A 2-year-old female with hypoplastic left heart syndrome (HLHS)-variant presented complications following single ventricle palliation, leading to elevated Fontan pathway pressures and significant dilation of the inferior Fontan pathway. Computational fluid dynamics (CFD) analysis revealed that the proposed endovascular revision would lead to unfavorable hemodynamic conditions, prompting the clinical team to reassess the patient's management. This study highlights the utility of CFD modeling in surgical planning for single ventricle CHD patients.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Engineering, Mechanical
Reza Sadeghi, Nadav Gasner, Seyedvahid Khodaei, Julio Garcia, Zahra Keshavarz-Motamed
Summary: The optimal course of intervention for patients with coexisting coarctation of the aorta (COA) and mixed valvular disease (MVD) is uncertain. This study developed a computational-mechanics framework to investigate the impact of COA and MVD on aortic fluid dynamics. The results suggest that the presence and severity of MVD should be considered in the evaluation of risks in patients with COA.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Nhien Tran-Nguyen, Francesca Condemi, Andrew Yan, Stephen Fremes, Piero Triverio, Laura Jimenez-Juan
Summary: This prospective study used computational fluid dynamics to investigate how graft hemodynamics may vary among different types of grafts one month after coronary artery bypass graft (CABG) surgery. The study found differences in abnormal wall shear stress area among different types of grafts, suggesting a possible influence on long-term graft failure rates.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Quanfei Hou, Wenqian Wu, Lingyun Fang, Xin Zhang, Chenchen Sun, Li Ji, Ming Yang, Ziqiao Lei, Fan Gao, Jing Wang, Mingxing Xie, Shu Chen
Summary: This study developed a patient-specific hemodynamics assessment using cardiac computed tomography angiography (CCTA) based computational fluid dynamics (CFD) for hypertrophic obstructive cardiomyopathy (HOCM) patients. The assessment accurately evaluated the morphology and hemodynamics of HOCM patients and predicted the volume of resected myocardium for septal myectomy when combined with virtual myectomy.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Siting Li, Xiaoning Sun, Mengyin Chen, Tianxiang Ma, Xiao Liu, Yuehong Zheng
Summary: This study aims to explore the effect of common hemodynamic parameters on visceral artery aneurysms (VAAs) and uses real patients' models for research. The results revealed that high-wall shear stress group had higher hemodynamic parameters compared to low-wall shear stress group, indicating their importance in the formation of VAAs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Physiology
Gyu-Han Lee, Hyun Jung Koo, Kyung Jin Park, Dong Hyun Yang, Hojin Ha
Summary: This study aimed to characterize the hemodynamics of Fontan patients using 4D Flow MRI and CFD. Hemodynamic parameters were estimated and compared between the two modalities. The results showed that there were discrepancies between 4D Flow MRI and CFD in terms of PFD and VD, highlighting the need for careful consideration when analyzing hemodynamic data from different modalities in Fontan patients.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
E. Hachem, P. Meliga, A. Goetz, P. Jeken Rico, J. Viquerat, A. Larcher, R. Valette, A. F. Sanches, V. Lannelongue, H. Ghraieb, R. Nemer, Y. Ozpeynirci, T. Liebig
Summary: This study aims to identify and characterize novel flow-deviator stent devices through a high-fidelity computational framework and deep reinforcement learning algorithms. The goal is to enable patient-specific treatment by accurately adjusting the functional parameters in the implanted state.
SCIENTIFIC REPORTS
(2023)
Article
Biophysics
Jonathan Pham, Sofia Wyetzner, Martin R. R. Pfaller, David W. W. Parker, Doug L. L. James, Alison L. L. Marsden
Summary: We propose svMorph, a framework for interactive virtual sculpting of patient-specific vascular anatomic models. Our tools allow the creation of tortuosity, aneurysms, and stenoses in tubular vascular geometries via geometric operations on the surface mesh and vessel centerline curves. The tortuosity tool uses the physics-based Oriented Particles method and linear blend skinning for smooth, elastic-like deformations.
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2023)
Article
Pediatrics
Rachel K. Hopper, Steven H. Abman, Eleni G. Elia, Catherine M. Avitabile, Delphine Yung, Mary P. Mullen, Eric D. Austin, Angela Bates, Stephanie S. Handler, Jeffrey A. Feinstein, D. Dunbar Ivy, John P. Kinsella, Kenneth D. Mandl, J. Usha Raj, Lynn A. Sleeper
Summary: This study characterized comorbidities, outcomes, and treatment patterns in children with Down syndrome and pulmonary hypertension. The results showed that despite the presence of cardiac and respiratory comorbidities, children with Down syndrome-associated pulmonary hypertension have a similar survival rate to those with non-Down syndrome-associated pulmonary hypertension.
JOURNAL OF PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Kara S. Motonaga, Loren Sacks, Inger Olson, Sowmya Balasubramanian, Sharon Chen, Lynn Peng, Jeffrey A. Feinstein, Norman H. Silverman, Frank L. Hanley, David M. Axelrod, Catherine D. Krawczeski, Alisa Arunamata, David M. Kwiatkowski, Scott R. Ceresnak
Summary: This study evaluated the effectiveness of an online preparatory course for paediatric cardiology fellows. The results showed that the course significantly improved participants' knowledge and comfort level, while reducing their anxiety.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Pediatrics
Rachel K. Hopper, Oscar van der Have, Seth A. Hollander, Anne I. Dipchand, Valeria Perez de Sa, Jeffrey A. Feinstein, Karin Tran-Lundmark
Summary: This study surveyed physicians at pediatric heart transplant centers and found significant variability in the management of elevated pulmonary vascular resistance in children awaiting heart transplant, highlighting the need for evidence-based guidelines.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Engineering, Biomedical
Victoria Yuan, Francesco De Gaetano, Kasra Osouli, Alison L. Marsden, Maria Laura Costantino
Summary: This study developed a computational model to simulate Norwood patients and evaluate the effects of Berlin Heart support on patient hemodynamics. The results showed that increasing device volume and rate can increase cardiac output, but have minimal impact on arterial oxygen content. Specific BH settings are recommended for patients with pulmonary hypertension and those treated with milrinone post-operatively. The findings emphasize that oxygen delivery does not increase with BH rate or volume and highlight the adaptability of the model to analyze BH support in different clinical situations.
Article
Computer Science, Interdisciplinary Applications
O. Z. Tikenogullari, M. Peirlinck, H. Chubb, A. M. Dubin, E. Kuhl, A. L. Marsden
Summary: Single ventricle patients, including those with hypoplastic left heart syndrome (HLHS), may develop arrhythmias, electrical dyssynchrony, and ventricular failure. The relationship between ventricular enlargement and electrical dysfunction in HLHS physiology is poorly understood. Computational modeling was used to characterize this relationship and found that right ventricle enlargement negatively affects QRS duration and interventricular dyssynchrony, while left ventricle enlargement can partially compensate for this dyssynchrony.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Letter
Public, Environmental & Occupational Health
Alison Marsden
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Lisa Wise-Faberowski, Jin Long, Michael Ma, Helen R. R. Nadel, Jennifer Shek, Jeffrey A. A. Feinstein, Elisabeth Martin, Frank L. L. Hanley, Doff B. B. McElhinney
Summary: In patients with tetralogy of Fallot and major aortopulmonary collaterals (MAPCAs), the pulmonary blood supply is highly variable. Our study analyzed serial lung perfusion scintigraphy (LPS) and found that pulmonary flow distribution prior to discharge was balanced, and there was minimal change over time. However, there was considerable patient-to-patient variation in both metrics.
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2023)
Article
Engineering, Biomedical
Aaron L. Brown, Fannie M. Gerosa, Jing Wang, Tzun Hsiai, Alison L. Marsden
Summary: Mechanical forces play a crucial role in coordinating cardiac morphogenesis, yet much remains unknown about their interactions with mechano-transduction pathways. Due to the complexity of cardiac mechanobiology, multiple experimental and analytical techniques are required for a complete understanding. This review focuses on computational modeling as a tool to investigate mechanobiological pathways in cardiac development. Recent studies show that understanding spatial and temporal patterns of biomechanical forces is crucial, and computational modeling provides an effective and efficient means to obtain such detail. Multidisciplinary studies combining all three tools yield the most compelling results.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Alexander D. Kaiser, Nicole K. Schiavone, Christopher J. Elkins, Doff B. McElhinney, John K. Eaton, Alison L. Marsden
Summary: The immersed boundary (IB) method is used in this study to simulate fluid-structure interaction (FSI) problems around heart valves. Physical experiments and numerical simulations were conducted, and the results showed excellent qualitative and quantitative agreement between the two, providing comparable experimental data for further validation studies of FSI simulations.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Jennifer E. Schramm, John C. Dykes, Rachel K. Hopper, Jeffrey A. Feinstein, David N. Rosenthal, Rebecca J. Kameny
Summary: This study reviewed the use of prostacyclin therapy in pediatric patients with high PVR on VAD support. The results showed that prostacyclins can effectively lower pulmonary vascular resistance, improve hemodynamic parameters, and increase the proportion of patients surviving to transplant in this high-risk cohort.
Article
Engineering, Multidisciplinary
Erica L. Schwarz, Martin R. Pfaller, Jason M. Szafron, Marcos Latorre, Stephanie E. Lindsey, Christopher K. Breuer, Jay D. Humphrey, Alison L. Marsden
Summary: This study implements a comprehensive, three-dimensional constrained mixture theory into a finite element fluid-structure interaction solver for simulating vascular growth and remodeling. The resulting solver allows long-term predictions of changing hemodynamics, vessel wall morphology, tissue composition, and material properties, enhancing the understanding of disease progression in complex environments.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Computer Science, Interdisciplinary Applications
Kathrin Baumler, Evan H. Phillips, Noelia Grande Gutierrez, Dominik Fleischmann, Alison L. Marsden, Craig J. Goergen
Summary: This study investigated the progression of false lumen thrombus over 7 days and found that flow stagnation is the predominant factor driving thrombus formation in the false lumen.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2023)
Article
Critical Care Medicine
Gregory T. Adamson, Jane Yu, Chandra Ramamoorthy, Lynn F. Peng, Anne Taylor, Michael Lennig, Alexander R. Schmidt, Jeffrey A. Feinstein, Manchula Navaratnam
Summary: The acute hemodynamic effect of vasopressin on the Fontan circulation was investigated in this study. The results showed that vasopressin administration significantly increased systolic blood pressure, systemic vascular resistance, and left atrial pressure, while decreasing pulmonary vascular resistance. However, it had no effect on cardiac index or pulmonary artery pressure. These findings suggest that vasopressin may be an option for treating systemic hypotension during sedation or general anesthesia in Fontan patients.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Carla Fiorella Murillo Perez, Shannon M. Vandriel, Jian-She Wang, Li Liting, Huiyu She, Irena Jankowska, Piotr Czubkowski, Dorota Gliwicz, Emmanuel Gonzales, Emmanuel Jacquemin, Jerome Bouligand, Lorenzo D'Antiga, Emanuele Nicastro, Bjorn Fischler, Henrik Arnell, Susan Siew, Michael Stormon, Kathleen M. Loomes, David A. Piccoli, Elizabeth B. Rand, James E. Squires, Saul J. Karpen, Rene Romero, Mureo Kasahara, Zerrin Onal, Etienne Sokal, Tanguy Demaret, Sabina Wiecek, Florence Lacaille, Dominique Debray, Winita Hardikar, Sahana Shankar, Pamela Valentino, Shikha Sundaram, Alexander Chaidez, Noelle Ebel, Jeffrey Feinstein, Yael Mozar-Glazberg, Henry Lin, Nathalie Rock, Henkjan J. Verkade, M. K. Jensen, Catalina Jaramillo, Kyungmo Kim, Seak Hee Oh, Jernej Brecelj, Seema Alam, Giuseppe Indolfi, Niviann Blondet, Rima Fawaz, Silvia Nastasio, Pier Luigi Calvo, Gabriella Nebbia, Cigdem Arikan, Catherine Larson-Nath, Andreanne N. Zizzo, Thomas Damgaard Sandahl, Christos Tzivinikos, Nehal El-Koofy, Mohamed Elmonem, Dev Desai, Wikrom Karnsakul, Palaniswamy Karthikeyan, Pinar Bulut, Nanda Kerkar, Victorien Wolters, Amin J. Roberts, Helen Evans, Maria Camila Sanchez, Maria Lorena Cavalieri, Deirdre Kelly, Way Seah Lee, Christina Hajinicolaou, Chatmanee Lertudomphonwanit, Ryan Fischer, Jesus Quintero Bernabeu, Ruben E. Quiros-Tejeira, Melina Melere, Elisa Carvalho, John Eshun, Aglaia Zellos, Antal Dezso Fi, Raquel Borges Pinto, Kathleen Schwarz, Maria Rogalidou, Jennifer Garcia, Maria Legarda Tamara, Marisa Beretta, Quais Mujawar, Ermelinda Santos-Silva, Cristina Molera Busoms, Eberhard Lurz, Cristina Goncalves, Carolina Jimenez-Rivera, Jesus M. Banales, Uzma Shah, Richard Thompson, Bettina Hansen, Binita M. Kamath
JOURNAL OF HEPATOLOGY
(2023)