Article
Developmental Biology
Samantha K. Swift, Alexandra L. Purdy, Mary E. Kolell, Kaitlyn G. Andresen, Caitlin Lahue, Tyler Buddell, Kaelin A. Akins, Christoph D. Rau, Caitlin C. O'Meara, Michaela Patterson
Summary: Somatic polyploidization is an adaptation observed in many cell types, including cardiomyocytes, where cells increase their DNA content to support growth. However, the progression to a polyploid state often leads to the loss of proliferative capacity. Recent research shows that genetics play a significant role in cardiomyocyte ploidy, but the developmental course to reach the final ploidy state has only been studied in select backgrounds.
Article
Cell Biology
Valentina C. Sladky, Hanan Akbari, Daniel Tapias-Gomez, Lauren T. Evans, Chelsea G. Drown, Margaret A. Strong, Gina M. LoMastro, Tatianna Larman, Andrew J. Holland
Summary: Hepatocyte polyploidization increases with age and the accumulation of centrioles and the presence of ANKRD26 are required for activating PIDDosome in polyploid cells. Under normal conditions, liver polyploidization does not affect organ function, but blocking centriole-mediated control leads to severe liver damage and impaired function in response to chronic liver injury.
GENES & DEVELOPMENT
(2022)
Article
Immunology
Liang Zhang, Zhentao Yang, Shiyu Zhang, Ke Zhou, Wu Zhang, Sunbin Ling, Ruiqi Sun, Hong Tang, Xue Wen, Xiaowen Feng, Penghong Song, Xiao Xu, Haiyang Xie, Shusen Zheng
Summary: This study investigates the association between hepatocyte polyploidy spectrum and hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). The high mononuclear polyploidy HCC (HMP-HCC) group showed inferior recurrence-free survival and HCC-specific survival compared to poorly mononuclear polyploidy HCC recipients. The composition of immune cells and levels of inflammatory cytokines were also different between these two groups. A scoring system incorporating the ploidy signature was developed and validated, which improved the risk prediction for HCC recurrence in LT patients.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Tomonori Matsumoto
Summary: Hepatocytes are polyploid cells that can proliferate and divide, playing a crucial role in maintaining liver homeostasis and regeneration. Alterations in hepatocyte ploidy are implicated in the pathogenesis of liver cirrhosis and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Peter M. Bourke, Roeland E. Voorrips, Christine A. Hackett, Geert van Geest, Johan H. Willemsen, Paul Arens, Marinus J. M. Smulders, Richard G. F. Visser, Chris Maliepaard
Summary: polyqtlR is a software tool designed for polyploid crops, allowing QTL interval mapping in populations of any ploidy level using identity-by-descent probabilities. It enables exploration of allelic composition of discovered QTL and includes visualization tools, as well as options to analyze polyploid meiosis processes.
Article
Multidisciplinary Sciences
Nimish Godbole, Iiris Nyholm, Maria Hukkinen, Joseph R. Davidson, Athanasios Tyraskis, Jouko Lohi, Paivi Heikkila, Katja Eloranta, Marjut Pihlajoki, Mark Davenport, Markku Heikinheimo, Antti Kyronlahti, Mikko P. Pakarinen
Summary: This study investigates the utility of secretin receptor (SCTR) as a potential biomarker for predicting native liver survival and clearance of jaundice after portoenterostomy (PE) surgery in patients with biliary atresia (BA). The results show that higher expression of SCTR is associated with lower 5-year native liver survival and clearance of jaundice after PE. SCTR expression also correlates with liver fibrosis, ductular reaction, and markers of fibrosis and cholangiocytes. Therefore, SCTR may serve as a promising prognostic marker for PE outcomes and liver injury in BA.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Maria Alexandra Rujano, David Briand, Bojana Delic, Julie Marc, Pauline Speder
Summary: This study reveals that the development of the neural stem cell niche in Drosophila involves complex proliferative strategies and atypical cell-cell fusion, providing insights into the architectural complexity and organization of the niche.
NATURE COMMUNICATIONS
(2022)
Review
Oncology
Romain Donne, Flora Sangouard, Severine Celton-Morizur, Chantal Desdouets
Summary: Polyploidy, or whole-genome amplification, is a condition where an organism has more than two basic sets of chromosomes, with diverse effects in different systems. The liver has the ability to adjust its ploidy, with about 30% of hepatocytes being polyploid. Research has explored mechanisms of polyploid cell development, regulation, consequences for liver function, and potential roles in tumor formation.
Review
Agronomy
Saeed Rauf, Rodomiro Ortiz, Dariusz P. Malinowski, Wellington Ronildo Clarindo, Wardah Kainat, Muhammad Shehzad, Ummara Waheed, Syed Wasim Hassan
Summary: Polyploidy refers to having more than two sets of chromosomes. It can be artificially induced in plants through various methods, leading to increased gene scope and expression, impacting yield and product quality. Experimentally induced polyploid germplasm is a valuable tool for understanding gene expression, but challenges related to genome and epigenome stability need to be addressed.
Article
Gastroenterology & Hepatology
Jun Zhang, Zhuwan Lyu, Bo Li, Zhengrui You, Nana Cui, You Li, Yikang Li, Bingyuan Huang, Ruiling Chen, Yong Chen, Yanshen Peng, Jingyuan Fang, Qixia Wang, Qi Miao, Ruqi Tang, M. Eric Gershwin, Min Lian, Xiao Xiao, Xiong Ma
Summary: This study found that P4HA2 can promote hepatic ductular reaction and biliary fibrosis by regulating the SAV1-mediated Hippo signaling pathway. Therefore, P4HA2 may be a potential therapeutic target for primary biliary cholangitis and primary sclerosing cholangitis.
Article
Geriatrics & Gerontology
Qinggui Liu, Fei Chen, Tao Yang, Jing Su, Shaohua Song, Zhi-Ren Fu, Yao Li, Yi-Ping Hu, Min-Jun Wang
Summary: The study demonstrates that senescent hepatocytes from aged liver can be rejuvenated after exposure to young blood, potentially through autonomous proliferation as the underlying mechanism of senescence reversal. Partial hepatectomy in aged liver exposed to young blood allows for the rescue of delayed DNA synthesis in senescent hepatocytes, facilitating liver regeneration. Aged-associated liver steatosis is alleviated as part of the senescence reversal process.
Article
Multidisciplinary Sciences
Atsushi Miura, Takashi Hosono, Taiichiro Seki
Summary: Depleting macrophages can suppress tissue remodeling and partially delay cell proliferation during regeneration after acute liver injury. Inhibiting tissue remodeling caused by depleted macrophages can delay the recovery of metabolic functions, indicating that liver injury affects liver metabolism.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ullas Chembazhi, Sushant Bangru, Mikel Hernaez, Auinash Kalsotra
Summary: The liver has a unique ability to regenerate in response to injuries, with a subset of hepatocytes reactivating early-postnatal-like gene expression program to proliferate and another population of metabolically active cells compensating for temporary deficits in liver function. The study also reveals the spatial and metabolic dynamics of hepatocyte proliferation after partial hepatectomy, with midlobular cells proliferating nearby while portal and central vein proximal hepatocytes remain metabolically active to preserve liver functions. Intercellular crosstalk and cellular reprogramming play a crucial role in balancing metabolic and proliferative requirements during liver regeneration.
Article
Gastroenterology & Hepatology
Yoichi Sato, Jiahe Qiu, Takuo Hirose, Takahiro Miura, Yasunori Sato, Masahiro Kohzuki, Osamu Ito
Summary: The study showed that metformin can slow down cyst formation and fibrosis in PCK rats, while also inhibiting excessive cell proliferation in the liver. It reduces the expression of proteins responsible for cystic fluid secretion and liver fibrosis, suggesting that metformin and AMPK activators could be potent drugs for polycystic liver disease.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Cell Biology
Kang Zheng, Fengjie Hao, Sandra Medrano-Garcia, Chaobo Chen, Feifei Guo, Laura Moran-Blanco, Sandra Rodriguez-Perales, Raul Torres-Ruiz, Maria Isabel Peligros, Javier Vaquero, Rafael Banares, Manuel Gomez del Moral, Jose R. Regueiro, Eduardo Martinez-Naves, Mohamed Ramadan Mohamed, Rocio Gallego-Duran, Douglas Maya, Javier Ampuero, Manuel Romero-Gomez, Albert Gilbert-Ramos, Sergi Guixe-Muntet, Anabel Fernandez-Iglesias, Jordi Gracia-Sancho, Mar Coll, Isabel Graupera, Pere Gines, Andreea Ciudin, Jesus Rivera-Esteban, Juan M. Pericas, Maria Dolores Frutos, Bruno Ramos Molina, Jose Maria Herranz, Matias A. Avila, Yulia A. Nevzorova, Edgar Fernandez-Malave, Francisco Javier Cubero
Summary: Progressive hepatic damage and fibrosis in chronic liver diseases can be controlled by N-RAS through downregulation of signaling pathways leading to hepatocyte necroptosis. This study suggests that N-RAS may have potential as a prognostic biomarker and therapeutic target for chronic liver diseases.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Geraldine Gentric, Yann Kieffer, Virginie Mieulet, Oumou Goundiam, Claire Bonneau, Fariba Nemati, Ilse Hurbain, Graca Raposo, Tatiana Popova, Marc-Henri Stern, Valerie Lallemand-Breitenbach, Sebastian Muller, Tatiana Caneque, Raphael Rodriguez, Anne Vincent-Salomon, Hugues de The, Rodrigue Rossignol, Fatima Mechta-Grigoriou
Article
Gastroenterology & Hepatology
Antoine L'Hermitte, Sandrine Pham, Mathilde Cadoux, Gabrielle Couchy, Stefano Caruso, Marie Anson, Anne-Marie Crain-Denoyelle, Severine Celton-Morizur, Satoshi Yamagoe, Jessica Zucman-Rossi, Chantal Desdouets, Jean-Pierre Couty
Article
Gastroenterology & Hepatology
Myriam Bou-Nader, Stefano Caruso, Romain Donne, Severine Celton-Morizur, Julien Calderaro, Geraldine Gentric, Mathilde Cadoux, Antoine L'Hermitte, Christophe Klein, Thomas Guilbert, Miguel Albuquerque, Gabrielle Couchy, Valerie Paradis, Jean-Pierre Couty, Jessica Zucman-Rossi, Chantal Desdouets
Review
Medicine, Research & Experimental
Romain Donne, Maeva Saroul, Vanessa Maillet, Severine Celton-Morizur, Chantal Desdouets
M S-MEDECINE SCIENCES
(2019)
Article
Multidisciplinary Sciences
Manon Fortier, Mathilde Cadoux, Nadia Boussetta, Sandrine Pham, Romain Donne, Jean-Pierre Couty, Chantal Desdouets, Severine Celton-Morizur
SCIENTIFIC REPORTS
(2019)
Review
Gastroenterology & Hepatology
Romain Donne, Maeva Saroul-Ainama, Pierre Cordier, Severine Celton-Morizur, Chantal Desdouets
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2020)
Article
Oncology
Yann Kieffer, Hocine R. Hocine, Geraldine Gentric, Floriane Pelon, Charles Bernard, Brigitte Bourachot, Sonia Lameiras, Luca Albergante, Claire Bonneau, Alice Guyard, Karin Tarte, Andrei Zinovyev, Sylvain Baulande, Gerard Zalcman, Anne Vincent-Salomon, Fatima Mechta-Grigoriou
Article
Gastroenterology & Hepatology
Mathilde Cadoux, Stefano Caruso, Sandrine Pham, Angelique Gougelet, Celine Pophillat, Rozenn Riou, Robin Loesch, Sabine Colnot, Cong Trung Nguyen, Julien Calderaro, Severine Celton-Morizur, Nadia Guerra, Jessica Zucman-Rossi, Chantal Desdouets, Jean-Pierre Couty
Summary: The expression of NKG2D ligands is associated with aggressive liver tumorigenesis, and downregulation of these ligands by beta-catenin signaling may contribute to the less aggressive phenotype of CTNNB1-mutated HCC tumors.
JOURNAL OF HEPATOLOGY
(2021)
Review
Oncology
Geraldine Gentric, Fatima Mechta-Grigoriou
Summary: Tumors exhibit metabolic heterogeneity with utilization of carbon sources other than glucose, such as amino acids, fatty acids, and lactate. This diversity in metabolic pathways influences cancer cell invasion capabilities and is also present in Cancer-Associated Fibroblasts (CAF).
Article
Oncology
Judith Goncalves, Sophie Moog, Aurelie Morin, Geraldine Gentric, Sebastian Muller, Alexander P. Morrell, Katarina Kluckova, Theodora J. Stewart, Cynthia L. Andoniadou, Charlotte Lussey-Lepoutre, Paule Benit, Alpesh Thakker, Lisa Vettore, Jennie Roberts, Raphael Rodriguez, Fatima Mechta-Grigoriou, Anne-Paule Gimenez-Roqueplo, Eric Letouze, Daniel A. Tennant, Judith Favier
Summary: Loss of different succinate dehydrogenase subunits can lead to different cell and tumor phenotypes, linking stronger 2-OG-dependent dioxygenase inhibition, iron overload, and ROS accumulation following SDHB mutation.
Review
Oncology
Romain Donne, Flora Sangouard, Severine Celton-Morizur, Chantal Desdouets
Summary: Polyploidy, or whole-genome amplification, is a condition where an organism has more than two basic sets of chromosomes, with diverse effects in different systems. The liver has the ability to adjust its ploidy, with about 30% of hepatocytes being polyploid. Research has explored mechanisms of polyploid cell development, regulation, consequences for liver function, and potential roles in tumor formation.
Article
Oncology
Raquel Vivet-Noguer, Malcy Tarin, Christine Canbezdi, Stephane Dayot, Lisseth Silva, Alexandre Houy, Sylvain Martineau, Virginie Mieulet, Geraldine Gentric, Damarys Loew, Berangere Lombard, Fariba Nemati, Sophie Richon, Lea Guyonnet, Vincent Servois, Stephan Vagner, Marc-Henri Stern, Sergio Roman-Roman, Samar Alsafadi
Summary: Cancer-associated SF3B1 mutations result in aberrant transcripts that alter protein translation in metabolic genes, leading to a switch towards increased glucose uptake and glycolysis dependency. This study provides evidence of the oncogenic involvement of mutant SF3B1 in uveal melanoma and suggests targeting glycolysis inhibitors as a potential therapeutic strategy.
Article
Oncology
Charlie Buchou, Karine Laud-Duval, Wietske van der Ent, Sandrine Grossetete, Sakina Zaidi, Geraldine Gentric, Maxime Corbe, Kevin Muller, Elaine Del Nery, Didier Surdez, Olivier Delattre
Summary: The study identified the MVA pathway as a major dependency in Ewing sarcoma, and statins as a potential new therapeutic agent for the treatment of this disease.
Meeting Abstract
Gastroenterology & Hepatology
Myriam Bou-Nader, Romain Donne, Stefano Caruso, Julien Calderaro, Geraldine Gentric, Antoine L'Hermitte, Thomas Guilbert, Christophe Klein, Gabrielle Couchy, Severine Celton-Morizur, Jean-Pierre Couty, Jessica Zucman-Rossi, Chantal Desdouets
Review
Gastroenterology & Hepatology
Leonard Depotte, Juliette Palle, Cosimo Rasola, Chloe Broudin, Vlad-Adrian Afrasanie, Antoine Mariani, Aziz Zaanan
Summary: Advanced gastric adenocarcinoma is a disease with poor prognosis. In recent years, new drugs, such as trastuzumab for HER2-positive tumors, ramucirumab alone or in combination with paclitaxel, and trifluridine-tipiracil, have improved patient survival. Other drugs, including monoclonal antibodies and targeted therapies, are also being evaluated.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2024)