期刊
CELL ADHESION & MIGRATION
卷 8, 期 2, 页码 67-75出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.28244
关键词
GTPase; Rho-GEF; signaling; extravasation; diapedesis; transmigration
类别
资金
- Landsteiner Foundation for Blood Transfusion Research (LSBR) fellowship [1028]
- NHS [2005T039]
Leukocyte transendothelial migration (TEM) is one of the crucial steps during inflammation. A better understanding of the key molecules that regulate leukocyte extravasation aids to the development of novel therapeutics for treatment of inflammation-based diseases, such as atherosclerosis and rheumatoid arthritis. The adhesion molecules ICAM-1 and VCAM-1 are known as central mediators of TEM. Clustering of these molecules by their leukocytic integrins initiates the activation of several signaling pathways within the endothelium, including a rise in intracellular Ca2+, activation of several kinase cascades, and the activation of Rho-GTPases. Activation of Rho-GTPases has been shown to control adhesion molecule clustering and the formation of apical membrane protrusions that embrace adherent leukocytes during TEM. Here, we discuss the potential regulatory mechanisms of leukocyte extravasation from an endothelial point of view, with specific focus on the role of the Rho-GTPases.
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