Review
Cell Biology
Maria Isabel Cuartero, Alicia Garcia-Culebras, Cristina Torres-Lopez, Violeta Medina, Enrique Fraga, Sandra Vazquez-Reyes, Tania Jareno-Flores, Juan M. Garcia-Segura, Ignacio Lizasoain, Maria angeles Moro
Summary: After stroke injury, there is ongoing neurogenesis in the adult mammalian brain which can contribute to recovery. However, the neurogenic response may lead to different functional consequences, suggesting a complex interplay between physiological and pathological regulation. More in-depth understanding is needed on the key cell types, cell-cell interactions, and molecular pathways involved in neurogenic response after brain damage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Radoslaw Kaczmarek, Katarzyna Zimmer, Pawel Gajdzis, Malgorzata Gajdzis
Summary: The cornea, though simple in appearance, is a highly complex structure that requires perfect organization of cells for maintaining its biomechanical and optical properties. Eph receptors and ephrins play a crucial role in tissue organization, cell migration, and communication, particularly in the regeneration process following injuries and diseases. This review examines the current understanding of Eph and ephrins in corneal physiology and diseases, with a focus on the epithelium and endothelium, as well as their influence on corneal neovascularization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Marta Gronksa-Peski, J. Tiago Goncalves, Jean M. Hebert
Summary: Research shows that an enriched environment promotes adult neurogenesis by increasing the function of fibroblast growth factor receptor (FGFR) within neurogenic cells. Activation of FGFR by an enriched environment signals through FGFR substrate (FRS) to induce stem cell proliferation and via FRS and phospholipase C gamma to increase the number of adult-born neurons.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Rachelle Mendoza, Nayanendu Saha, Amir Momeni, Elmer Gabutan, Mouyed Alawad, Amir Dehghani, John Diks, Bo Lin, Donghai Wang, Mohamed Alshal, William Fyke, Bingcheng Wang, Juha P. Himanen, Prem Premsrirut, Dimitar B. Nikolov
Summary: Research has shown that serum levels of ephrin-A1 and ADAM12 are significantly elevated in COVID-19 patients and correlate with disease progression, indicating potential targets for therapeutic development. Conversely, TNF alpha and ADAM17 levels were elevated in a small subset of patients, suggesting a different inflammatory pathway in COVID-19 progression.
Article
Biochemistry & Molecular Biology
Razieh Jaberi, Sara Mirsadeghi, Sahar Kiani
Summary: NSCs are multipotent, self-renewable cells located in the subventricular zone of the adult brain, capable of differentiating into various types of neural cells. Through in vitro methods, NSCs can be successfully isolated, expanded, and characterized, showing their cell survival and self-renewal capacity.
MOLECULAR BIOLOGY REPORTS
(2021)
Review
Neurosciences
Chiara Ossola, Nereo Kalebic
Summary: The development of the cerebral cortex is a complex process, and disturbances in the characteristics of neural progenitor cells are associated with cortical developmental abnormalities that can lead to neurodevelopmental disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Abigail A. Kindberg, Vasudha Srivastava, Jonathon M. Muncie, Valerie M. Weaver, Zev J. Gartner, Jeffrey O. Bush
Summary: The study reveals that EPH/EPHRIN signaling decreases the stability of heterotypic cell:cell contacts through increased cortical actomyosin contractility, driving cellular self-organization. The cell segregation driven by EPH/EPHRIN depends on actomyosin contractility but occurs independently of directed cell migration and without changes in cell adhesion.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hiroyoshi Doi, Taito Matsuda, Atsuhiko Sakai, Shuzo Matsubara, Sumio Hoka, Ken Yamaura, Kinichi Nakashima
Summary: Early-life exposure to midazolam alters neural stem cells in the mouse hippocampus, leading to reduced neurogenesis and impaired memory functions. Voluntary exercise can restore hippocampal neurogenesis, normalize the transcriptome, and improve cognitive abilities in exposed mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Kathrin Barth, Verica Vasic, Brennan McDonald, Nora Heinig, Marc-Christoph Wagner, Ulrike Schumann, Cora Roehlecke, Frank Bicker, Lana Schumann, Konstantin Radyushkin, Jan Baumgart, Stefan Tenzer, Frauke Zipp, Matthias Meinhardt, Kari Alitalo, Irmgard Tegeder, Mirko H. H. Schmidt
Summary: Mature neurons, neural stem cells, and neural precursor cells secrete the neurovascular protein EGFL7 to shape the neurogenic niche of the hippocampus. Ablation of EGFL7 leads to increased neurogenesis and is correlated with elevated expression of VEGF-D. Infusion of VEGF-D increases neurogenesis, while its knockout decreases neurogenesis. Furthermore, EGFL7 knockout mice show improved spatial memory and memory consolidation in the hippocampus.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Cell Biology
Elisa Damo, Manuela Simonetti
Summary: Chronic pain is a debilitating condition that affects various aspects of patients' lives, and finding better treatments is of great interest to researchers. Developmental molecules such as Wnt, ephrins, and semaphorins play important roles in the normal growth of biological systems. Their pathways contribute to the development, maintenance, and resolution of pain by impacting both neurons and glial cells. This review summarizes the current understanding of these pathways and their mechanisms in experimental animal models, providing insights into their involvement in the chronicity of pain.
Article
Cell Biology
Rafal Platek, Piotr Rogujski, Jaroslaw Mazuryk, Marta B. Wisniewska, Leszek Kaczmarek, Artur Czupryn
Summary: In the adult brain, new neurons are derived from two neurogenic regions: the subventricular zone (SVZ) and the subgranular layer of the hippocampal dentate gyrus. This study found that the loss of Cyclin D2 gene reduces the proliferation of neural precursors and progenitors, leading to a decrease in the production of interneurons in the olfactory bulbs.
Article
Neurosciences
Chen Dong, Chuntao Zhao, Xiang Chen, Kalen Berry, Jiajia Wang, Feng Zhang, Yunfei Liao, Rong Han, Sean Ogurek, Lingli Xu, Li Zhang, Yifeng Lin, Wenhao Zhou, Mei Xin, Daniel A. Lim, Kenneth Campbell, Masato Nakafuku, Ronald R. Waclaw, Q. Richard Lu
Summary: This study identifies the stage-dependent functions of CHD8 in neurogenesis, including the regulation of neural stem/progenitor cell proliferation and survival, the production of transit-amplifying intermediate progenitors (IPCs), and the activation of neurogenesis-promoting factors. It also reveals that CHD8 controls chromatin accessibility to activate neurogenesis-promoting factors and repress apoptotic programs. In the adult brain, CHD8 depletion impairs neurogenesis but does not affect NSC proliferation and survival, and this impairment can be partially restored with fluoxetine treatment.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Ugo Tomasello, Esther Klingler, Mathieu Niquille, Nandkishor Mule, Antonio J. Santinha, Laura de Vevey, Julien Prados, Randall J. Platt, Victor Borrell, Denis Jabaudon, Alexandre Dayer
Summary: This study reveals the regulatory role of the outer subventricular zone (oSVZ) and two microRNAs (miR-137 and miR-122) in cortical expansion, enhancing our understanding of cortical development and evolution.
Article
Chemistry, Medicinal
Claudio Festuccia, Miriam Corrado, Alessandra Rossetti, Riccardo Castelli, Alessio Lodola, Giovanni Luca Gravina, Massimiliano Tognolini, Carmine Giorgio
Summary: This study demonstrated the inhibitory effects of Eph antagonism on prostate cancer both in vitro and in vivo. The Eph antagonist UniPR1331 inhibited PC3 cell growth, induced apoptosis, and downregulated epithelial mesenchymal transition markers. Furthermore, UniPR1331 reduced PC3 cell migration, invasion, and vasculomimicry capabilities.
Article
Biochemistry & Molecular Biology
Felipe Mora-Bermudez, Elena Taverna, Wieland B. Huttner
Summary: Comparing the neural cells of hominids reveals significant differences in the regulation of processes such as proliferation and differentiation of neural stem and progenitor cells (NSPCs) and maturation of neurons, with the timing of these processes emerging as a foundational difference in neocortex development among hominids.
Article
Biochemistry & Molecular Biology
Eniko Csata, Jacques Gautrais, Adrian Bach, Jean Blanchet, Jeremy Ferrante, Floriane Fournier, Tina Levesque, Stephen J. Simpson, Audrey Dussutour
Article
Optics
P. Lapeyre, S. Blanco, C. Caliot, J. Dauchet, M. El Hafi, R. Fournier, O. Farges, J. Gautrais, M. Roger
JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
(2020)
Article
Multidisciplinary Sciences
Leo Guignard, Ulla-Maj Fiuza, Bruno Leggio, Julien Laussu, Emmanuel Faure, Gael Michelin, Kilian Biasuz, Lars Hufnagel, Gregoire Malandain, Christophe Godin, Patrick Lemaire
Correction
Biology
Frederic Bonnet, Angie Molina, Melanie Roussat, Manon Azais, Sophie Bel-Vialar, Jacques Gautrais, Fabienne Pituello, Eric Agius
Article
Behavioral Sciences
Jeanne Legros, Grace Tang, Jacques Gautrais, Maria Paz Fernandez, Severine Trannoy
Summary: Most animal species display aggressive behavior in competition for food, mates and territory, a behavior shaped by evolution. Environmental pressure, such as long-term dietary restrictions, forces animals to adapt and develop alternative fighting strategies. This study shows that fruit flies raised under different dietary conditions have adapted their aggressive behavior patterns and developed distinct fighting strategies.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Meteorology & Atmospheric Sciences
Najda Villefranque, Stephane Blanco, Fleur Couvreux, Richard Fournier, Jacques Gautrais, Robin J. Hogan, Frederic Hourdin, Victoria Volodina, Daniel Williamson
Summary: The process-scale development, evaluation, and calibration of physically based clouds and radiation parameterizations using machine learning techniques can improve weather and climate models. Calibrating cloud geometry parameters can lead to better predictions of TOA and surface fluxes, but does not reduce errors on absorption.
JOURNAL OF ADVANCES IN MODELING EARTH SYSTEMS
(2021)
Article
Biochemical Research Methods
Thibault Dubois, Cristian Pasquaretta, Andrew B. Barron, Jacques Gautrais, Mathieu Lihoreau
Summary: Bees and other pollinating animals establish idiosyncratic foraging routes to efficiently collect resources, while avoiding overlapping with competitors to partition resources effectively. The study introduces a computational model suggesting bees can develop efficient routes between flowers based on their history of reinforcement in a floral array. This strategy promotes efficient foraging among competing agents on a renewable resource, highlighting the importance of spatial segregation and efficient collective foraging in complex environments.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Developmental Biology
Angie Molina, Frederic Bonnet, Julie Pignolet, Valerie Lobjois, Sophie Bel-Vialar, Jacques Gautrais, Fabienne Pituello, Eric Agius
Summary: Although the lengthening of cell cycle and G1 phase is a common phenomenon during tissue maturation, the underlying mechanism is still unclear. This study developed a time-lapse imaging strategy to measure the four cell cycle phases in single chick neural progenitor cells, and found that neural progenitors exhibit wide heterogeneity in cell cycle length. The study also identified a mechanism that contributes to the lengthening of G1 phase.
Review
Multidisciplinary Sciences
Najda Villefranque, Frederic Hourdin, Louis d'Alencon, Stephane Blanco, Olivier Boucher, Cyril Caliot, Christophe Coustet, Jeremi Dauchet, Mouna El Hafi, Vincent Eymet, Olivier Farges, Vincent Forest, Richard Fournier, Jacques Gautrais, Valery Masson, Benjamin Piaud, Robert Schoetter
Summary: This article reviews the scientific advances in urban climate modeling and highlights the potential of combining mathematics, physics, computer, and engineering sciences in this field. Simulating coupled heat transfer in complex urban geometries allows for a better understanding, prediction, and improvement of urban energy performance.
Article
Neurosciences
Lina Bonilla, Jacques Gautrais, Simon Thorpe, Timothee Masquelier
Summary: This theoretical paper focuses on information coding and decoding in spiking neural networks using time-to-first-spike (TTFS) codes. It introduces a new mathematical framework that allows the comparison of various coding schemes. The paper compares three coding schemes - ROC, NoM, and R-NoM - in terms of discriminability and finds that R-NoM has higher discriminability, especially in the early phase of responses. The paper also argues that R-NoM is more hardware-friendly compared to the original ROC proposal, although NoM remains the easiest to implement because it requires binary synapses.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
V. Balaji, Fleur Couvreux, Julie Deshayes, Jacques Gautrais, Frederic Hourdinf, Catherine Rio
Summary: Traditional general circulation models (GCMs) have been a main tool in climate research, but they have limitations. Future models can address these limitations through higher resolution and machine learning techniques. Calibration is key to understanding the inner workings of complex systems. GCMs will continue to play a central role in future climate research.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Jean Marc Tregan, Jean Luc Amestoy, Megane Bati, Jean-Jacques Bezian, Stephane Blanco, Laurent Brunel, Cyril Caliot, Julien Charon, Jean-Francois Cornet, Christophe Coustet, Louis d'Alencon, Jeremi Dauchet, Sebastien Dutour, Simon Eibner, Mouna El Hafi, Vincent Eymet, Olivier Farges, Vincent Forest, Richard Fournier, Mathieu Galtier, Victor Gattepaille, Jacques Gautrais, Zili He, Frederic Hourdin, Loris Ibarrart, Jean-Louis Joly, Paule Lapeyre, Pascal Lavieille, Marie-Helene Lecureux, Jacques Lluc, Marc Miscevic, Nada Mourtaday, Yaniss Nyffenegger-Pere, Lionel Pelissier, Lea Penazzi, Benjamin Piaud, Clement Rodrigues-Viguier, Gisele Roques, Maxime Roger, Thomas Saez, Guillaume Terree, Najda Villefranque, Thomas Vourc'h, Daniel Yaacoub
Summary: It has been shown recently that radiation, conduction, and convection can be combined in a single Monte Carlo algorithm, benefiting from computer-graphics advances for complex geometries. The theoretical foundations for this coupling are fully exposed for the first time, demonstrating continuous thermal paths through different physics. The proposal includes the use of propagators, Green's functions, and Brownian trajectories compatible with ray-tracing acceleration techniques.
Article
Biochemical Research Methods
Ana Moran, Mathieu Lihoreau, Alfonso Perez Escudero, Jacques Gautrais
Summary: This study developed a model that incorporates realistic features of bee behavior to show that the probability of discovering a flower depends not only on its position but also on the position of other flowers around it. This "masking effect" may have important implications for plant pollination and terrestrial ecosystems.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Computer Science, Software Engineering
Megane Bati, Stephane Blanco, Christophe Coustet, Vincent Eymet, Vincent Forest, Richard Fournier, Jacques Gautrais, Nicolas Mellado, Mathias Paulin, Benjamin Piaud
Summary: This paper introduces a coupled path-space Monte Carlo algorithm for efficient multi-physics problems solving. By combining knowledge from physics and computer graphics, different simulation spaces are formulated and arranged into a single path space, enabling coupled heat transfer simulation using Monte Carlo. The proposed method allows for interactive computation of multiple simulations with different conditions in the same scene, validated through various thermal simulation scenarios. The theoretical framework presented in this work is expected to foster collaboration and multidisciplinary studies in resolving coupled PDEs at the interface of physics and computer graphics.
ACM TRANSACTIONS ON GRAPHICS
(2023)
Article
Physics, Fluids & Plasmas
Guillaume Terree, Mouna El Hafi, Stephane Blanco, Richard Fournier, Jeremi Dauchet, Jacques Gautrais
Summary: This article proposes a statistical numerical method for addressing gas kinetics problems based on the Boltzmann equation. Inspired by Monte Carlo algorithms used in linear transport physics, this method tracks virtual particles backwards in time along their paths. The nonlinear nature of gas kinetics is represented in the numerical simulations by branching of virtual particle paths.
