Review
Cell Biology
David G. Wilkinson
Summary: Cell segregation to form sharp boundaries is crucial for stabilizing tissue organization and is driven by differential adhesion mediated by cadherins and Eph receptor/ephrin signaling regulating cell adhesion, cortical tension, and repulsion. These mechanisms interplay with cadherins antagonizing homotypic tension within cell populations and Eph receptors mainly driving segregation through increased heterotypic tension or repulsion. The differential tension between homotypic and heterotypic tensions ultimately leads to cell segregation and border sharpening.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Lujuan Wang, Wei Li, Yong Pan
Summary: The Eph/Ephrins system plays a dual role in both suppressing and promoting tumors in primary bone tumors and bone cancer pain. Understanding the intracellular mechanisms of the Eph/Ephrins system in tumorigenesis and metastasis of bone tumors may provide a foundation for the development of targeted anti-cancer therapy.
Review
Biochemistry & Molecular Biology
Argyris C. Hadjimichael, Alexandros Pergaris, Angelos Kaspiris, Athanasios F. Foukas, Stefania Kokkali, Gerasimos Tsourouflis, Stamatios Theocharis
Summary: Musculoskeletal sarcomas are rare heterogeneous malignancies of mesenchymal origin, with two distinct subtypes, bone and soft tissue sarcomas. The EPH/ephrin signaling pathway plays an important role in sarcoma progression, with significant interactions with various normal and abnormal cascades. EPHs and ephrins have potential as candidates for diagnosis, monitoring, and therapy against bone and soft tissue sarcomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Agnieszka Arthur, Stan Gronthos
Summary: Skeletal integrity is maintained through a tightly regulated bone remodeling process involving interactions between different cellular systems within the bone microenvironment. Disruption of these dynamic interactions can lead to poor bone health and an increased susceptibility to skeletal diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Wenqing Li, Lai Wen, Bhavisha Rathod, Anne-Claude Gingras, Klaus Ley, Ho-Sup Lee
Summary: This study reveals that kindlin2 can mediate bi-directional ephrinB signaling through binding to a conserved NIYY motif in the ephrinB2 cytoplasmic tail. The interaction is important for EphB/ephrinB-mediated integrin activation in mammalian cells and blood vessel morphogenesis in zebrafish development.
LIFE SCIENCE ALLIANCE
(2022)
Article
Immunology
Rene Reitermaier, Thomas Krausgruber, Nikolaus Fortelny, Tanya Ayub, Pablo Augusto Vieyra-Garcia, Philip Kienzl, Peter Wolf, Anke Scharrer, Christian Fiala, Marita Kolz, Manuela Hiess, Martin Vierhapper, Christopher Schuster, Andreas Spittler, Christof Worda, Wolfgang Weninger, Christoph Bock, Rene Reitermaier, Adelheid Elbe-Buerger
Summary: Single-cell analyses identified a naive T cell population expressing specific T cell receptors enriched in fetal skin and intestine. These cells may contribute to early skin development and fetal immune defense, showing fundamental differences in immune surveillance between fetal and adult human skin.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biology
Matthias Blanc, Giovanni Dalmasso, Frederic Udina, Cristina Pujades, Kristin Tessmar-Raible
Summary: This study developed a digital 3D-atlas maker (DAMAKER) to reconstruct a digital 3D-atlas of the neuronal differentiation domain in the zebrafish hindbrain. By integrating spatial and temporal data, they quantified the dynamic growth of the neuronal differentiation domain and revealed the spatial distribution patterns of neurons in the tissue. The digital birthdating 3D-maps could serve as a proxy to infer neuronal birthdate.
Article
Biochemistry & Molecular Biology
Hui Song Cui, So Young Joo, Seung Yeol Lee, Yoon Soo Cho, Dong Hyun Kim, Cheong Hoon Seo
Summary: It is unclear how scar fibroblasts (SFs) affect keratinocytes in hypertrophic scars (HTS) through cell-cell interaction. This study investigated the effects of HTS-derived exosomes on the proliferation and differentiation of normal human keratinocytes (NHKs) and compared them with normal fibroblasts (NFs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eisaku Ogawa, Tomohiro Edamitsu, Hidetaka Ohmori, Kazuyoshi Kohu, Mineo Kurokawa, Hiroshi Kiyonari, Masanobu Satake, Ryuhei Okuyama
Summary: This study reveals the important roles of Runx1 and Runx3 in keratinocyte differentiation, where they directly inhibit the expression of keratin 1 and keratin 10 genes during the differentiation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Ruben Boers, Joachim Boers, Beatrice Tan, Marieke E. van Leeuwen, Evelyne Wassenaar, Erlantz Gonzalez Sanchez, Esther Sleddens, Yasha Tenhagen, Eskeatnaf Mulugeta, Joop Laven, Menno Creyghton, Willy Baarends, Wilfred F. J. van IJcken, Joost Gribnau
Summary: In this study, a bacterial methylation mark was used to label transcribed genes and active enhancers, allowing for tracking of cell state changes. This technique revealed rapid and coordinated activation of enhancers and nearby genes during enterocyte differentiation in the intestine. Furthermore, it provided insights into the chromatin landscape of intestinal stem cells and their differentiation process.
NATURE BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Abdalla Sheikh, Jennie Jackson, Hanjoo Brian Shim, Clement Yau, Jung Hee Seo, Ninan Abraham
Summary: Interleukin-7 (IL-7) plays an important role in shaping CD8 T cell responses during acute viral infections. IL-7 is required for proper expansion and effector functions of influenza-specific CD8 T cells in the mediastinal lymph node. IL-7 also affects terminal differentiation, degranulation, and cytokine production of specific CD8 T cells. Understanding IL-7's role in respiratory diseases will help expand therapeutic options.
SCIENTIFIC REPORTS
(2022)
Article
Cell & Tissue Engineering
Kristijan Pazur, Ioannis Giannios, Mathias Lesche, Eva Rodriguez-Aznar, Anthony Gavalas
Summary: Hoxb1 plays different roles in neuromesodermal progenitors and hindbrain neural progenitors, promoting survival and specifying neural cell differentiation through regulation of Fgf signaling and synergistic interaction with shh. This highlights the potential of Hox genes in guiding cell specification and transplantation for neurodegenerative diseases.
Article
Dentistry, Oral Surgery & Medicine
Marie Elise Jennes, Pascal Tomakidi, Ayman Husari, Elmar Hellwig, Olga Polydorou, Simon Daniel Schulz
Summary: This study investigated the influence of hybrid CAD/CAM blocks on immortalized human gingival keratinocytes (HGK). The results showed that two hybrid materials did not have a significant effect on cell behavior analysis, while the ceram.x (R) universal material had cytotoxic effects on cell proliferation, morphology, and protein expression.
Article
Cell Biology
Lei Qiang, Seungwon Yang, Yan-Hong Cui, Yu-Ying He
Summary: The study found that inhibiting epidermal cell autophagy impairs wound healing in mice, affecting processes such as keratinocyte proliferation, immune cell infiltration, and dermal tissue formation. TNF induces CCL2 transcription through the autophagy-AMPK-BRAF-MAPK1/3/ERK-AP1 pathway, influencing keratinocyte migration and proliferation, and activating dermal fibroblasts.
Article
Immunology
Daniel B. Stamos, Lauren M. Clubb, Apratim Mitra, Laura B. Chopp, Jia Nie, Yi Ding, Arundhoti Das, Harini Venkataganesh, Jan Lee, Dalal El-Khoury, LiQi Li, Avinash Bhandoola, Remy Bosselut, Paul E. Love
Summary: The study demonstrates the critical role of the histone demethylase Lsd1 in regulating stem/progenitor transcriptional programs and repressive gene programs during T cell development, shedding light on epigenetic mechanisms underlying the acquisition of T cell gene signatures.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Developmental Biology
Jordi Cayuso, Qiling Xu, David G. Wilkinson
DEVELOPMENTAL BIOLOGY
(2015)
Editorial Material
Cell Biology
David G. Wilkinson
JOURNAL OF CELL BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
John Jacob, Jennifer Kong, Steven Moore, Christopher Milton, Noriaki Sasai, Rosa Gonzalez-Quevedo, Javier Terriente, Itaru Imayoshi, Ryoichoro Kageyama, David G. Wilkinson, Bennett G. Novitch, James Briscoe
Article
Developmental Biology
Javier Terriente, Sebastian S. Gerety, Tomomi Watanabe-Asaka, Rosa Gonzalez-Quevedo, David G. Wilkinson
Article
Developmental Biology
Marie A. Breau, Duncan Wilson, David G. Wilkinson, Qiling Xu
Article
Developmental Biology
Sebastian S. Gerety, Marie A. Breau, Noriaki Sasai, Qiling Xu, James Briscoe, David G. Wilkinson
Article
Developmental Biology
Sebastian S. Gerety, David G. Wilkinson
DEVELOPMENTAL BIOLOGY
(2011)
Article
Cell Biology
Rosa Gonzalez-Quevedo, Yoonsung Lee, Kenneth D. Poss, David G. Wilkinson
DEVELOPMENTAL CELL
(2010)
Article
Cell Biology
John Jacob, Vanessa Ribes, Steven Moore, Sean C. Constable, Noriaki Sasai, Sebastian S. Gerety, Darren J. Martin, Chris P. Sergeant, David G. Wilkinson, James Briscoe
DISEASE MODELS & MECHANISMS
(2014)
Article
Multidisciplinary Sciences
William R. Taylor, Rosalind Morley, Alexey Krasavin, Lauren Gregory, David G. Wilkinson, Alexei Poliakov
Article
Multidisciplinary Sciences
Katie E. Foster, Julie Gordon, Kim Cardenas, Henrique Veiga-Fernandes, Taija Makinen, Elena Grigorieva, David G. Wilkinson, C. Clare Blackburn, Ellen Richie, Nancy R. Manley, Ralf H. Adams, Dimitris Kioussis, Mark C. Coles
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2010)
Article
Multidisciplinary Sciences
Marie A. Breau, David G. Wilkinson, Qiling Xu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2013)
Article
Cell Biology
Eduard Batlle, David G. Wilkinson
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2012)
Article
Developmental Biology
Qiling Xu, David G. Wilkinson
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY
(2013)