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Tenascin-C Signaling in melanoma

期刊

CELL ADHESION & MIGRATION
卷 9, 期 1-2, 页码 125-130

出版社

TAYLOR & FRANCIS INC
DOI: 10.4161/19336918.2014.972781

关键词

invasion; melanoma; survival; Tenascin-C

资金

  1. National Institutes of Health (NIGMS)
  2. VA Merit Award Program
  3. SPORE [P50 CA121973-07]

向作者/读者索取更多资源

Tenascin-C (TNC), a multifunctional matricellular glyco-protein, is highly expressed in the majority of melanoma cell lines and has been implicated in the progression of melanoma. A growing body of evidence has implicated the role of TNC in the process of invasion and metastasis for melanoma. However, the mechanism and individual signaling pathways by which TNC drives melanoma progression have not been illuminated. Herein we provide perspectives from the investigation of TNC in other settings that may hint at the mechanistic role of TNC in this disease.

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