期刊
CELL ADHESION & MIGRATION
卷 7, 期 1, 页码 90-100出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.22236
关键词
basement membranes; cell receptors; extracellular matrix; stem cells; signaling pathways
类别
资金
- Institute National Contre le Cancer (INCa)
- ANR
- ARC
- Oncosuisse
- Hautepierre Hospital
- Ligue Nationale Contre le Cancer (CCIR-GE)
- Strasbourg University
- INSERM
- US National Institutes of Health [R01DK078314, R01GM060432]
Laminins (LM) are extracellular matrix molecules that contribute to and are required for the formation of basement membranes. They participate in the modulation of epithelial/mesenchymal interactions and are implicated in organogenesis and maintenance of organ homeostasis. Among the LM molecules, the LM alpha 5 chain (LM alpha 5) is one of the most widely distributed LM in the developing and mature organism. Its presence in some basement membranes during embryogenesis is absolutely required for maintenance of basement membrane integrity and thus for proper organogenesis. LMa5 also regulates the expression of genes important for major biological processes, in part by repressing or activating signaling pathways, depending upon the physiological context.
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