期刊
CELL ADHESION & MIGRATION
卷 7, 期 5, 页码 424-425出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.26728
关键词
EMT; c-Met; IGF-1; Leptin; triple negative; breast cancer; metastasis & cancer mortality
类别
资金
- Canadian Institutes for Health Research (CIHR)
- Cancer Research Society Inc. of Canada
- National Colorectal Cancer Campaign
- Fonds de la Recherche en Sante du Quebec (FRSQ-Reseau du Cancer)
Triple negative breast cancers (TNBCs) represent a distinct subtype of breast cancers that are associated with early recurrence and an aggressive metastatic progression of the disease and consequently poor outcome. Recently, it was reported that c-Met growth factor receptor is overexpressed in around 52% of TNBCs. On the other hand, it is known that c-Met signaling pathways initiate the epithelial-mesenchymal transition (EMT) phenomenon, which is described as a crucial event during cancer metastasis. Herein, we discuss the association between c-Met and EMT in the TNBC group.
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