期刊
CELL ADHESION & MIGRATION
卷 7, 期 1, 页码 142-149出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.22125
关键词
laminin; integrins; metastasis; extracellular matrix; breast cancer; adhesion; migration; invasion
类别
资金
- National Health and Medical Research Council of Australia
- PeterMac Cancer Foundation
Laminins are major constituents of basement membranes. At least 16 isoforms have now been described, each with distinct spatio-temporal expression patterns and functions. The laminin-511 heterotrimer (alpha 5 beta 1 gamma 1) is one of the more recent isoforms to be identified and a potent adhesive and promigratory substrate for a variety of normal and tumor cell lines in vitro. As our understanding of its precise function in normal tissues and in pathologies is rapidly unraveling, current evidence suggests an important regulatory role in cancer. This review describes published data on laminin-511 expression in several malignancies and experimental evidence from both in vitro and in vivo studies supporting its functional role during tumor progression. A particular emphasis is put on more recent studies from our laboratory and that of others indicating that laminin-511 contributes to tumor dissemination and metastasis in advanced breast carcinomas and other tumor types. Collectively, the experimental evidence suggests that high expression of laminin-511 has prognostic significance and that targeting tumor-laminin-511 interactions may have therapeutic potential in advanced cancer patients.
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