Article
Peripheral Vascular Disease
Vivien Becker, Xin Hui, Lisa Nalbach, Emmanuel Ampofo, Peter Lipp, Michael D. Menger, Matthias W. Laschke, Yuan Gu
Summary: The study demonstrated that linalool can effectively inhibit the angiogenic activity of endothelial cells, which may be mediated by regulating the ERK signaling pathway, downregulating intracellular ATP levels, and activating TRPM8 channels.
Article
Engineering, Biomedical
Dasom Kim, Kyeong Seob Hwang, Eun U. Seo, Suyeong Seo, Byung Chul Lee, Nakwon Choi, Jonghoon Choi, Hong Nam Kim
Summary: The tumor microenvironment (TME) plays a complex role in tumor growth and drug delivery. A method for inducing controlled tumor angiogenesis by engineering the microenvironment is presented. This vascularized tumor platform can enhance the delivery of anticancer drugs and immune cells, and aid in the development of effective anticancer drugs and cancer immunotherapy.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Melissa Garcia-Caballero, Liliana Sokol, Anne Cuypers, Peter Carmeliet
Summary: The dynamic crosstalk between different components of the tumor microenvironment plays a critical role in cancer progression and metastasis. Angiogenesis is crucial for tumor growth, but abnormal blood vessels can lead to hypoxia and acidosis in the tumor microenvironment. Cancer and stromal cells can alter their metabolism to meet high energy demands and promote tumor proliferation. Recent studies have shown that the metabolism of tumor endothelial cells is reprogrammed and targeting these metabolic pathways can affect blood vessel formation. Therefore, metabolic antiangiogenic therapies combined with immunotherapies offer a clinical opportunity for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Feng Luo, Ruyi Li, Huaping Zheng, Yichen Xu, Linxin Yang, Changxing Qu, Guang Hong, Qianbing Wan
Summary: Carbon nanotubes (CNTs) are a promising bioactive scaffold for bone regeneration, but their effect on vascularization is minimal. In this study, SWNTs/EDC composite was found to promote the differentiation of bone mesenchymal stem cells (BMSCs) into vascular endothelial cell-like cells (VEC-like cells) and positively affect angiogenesis and bone regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Peripheral Vascular Disease
Sara Petrillo, F. De Giorgio, F. Bertino, F. Garello, V Bitonto, D. L. Longo, S. Mercurio, G. Ammirata, A. L. Allocco, V Fiorito, D. Chiabrando, F. Altruda, E. Terreno, P. Provero, L. Munaron, T. Genova, A. Novoa, A. R. Carlos, S. Cardoso, M. Mallo, M. P. Soares, E. Tolosano
Summary: The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is highly expressed in angiogenic endothelial cells (ECs) and has a critical role in developmental and pathological angiogenesis. Deficiency of FLVCR1a leads to abnormal vascular networks in multiple models, including defective vessel formation in zebrafish embryos, reduced retinal vasculature expansion and EC proliferation in mice, and disorganized and dysfunctional tumor blood vessels. These findings suggest FLVCR1a as a potential therapeutic target for diseases characterized by aberrant neovascularization.
Article
Health Care Sciences & Services
Igor Maiborodin, Alfija Mansurova, Alexander Chernyavskiy, Alexander Romanov, Vladimir Voitcitctkii, Anna Kedrova, Alexander Tarkhov, Alena Chernyshova, Sergey Krasil'nikov
Summary: Based on recent scientific literature on neovascularization and angiogenesis in malignant neoplasms, it is concluded that there are numerous studies on tumor angiogenesis and vascularization. The formation of blood vessels in tumors and the prognostic value of vascularization severity in almost all cancer forms are discussed. Angiogenesis in tumors of the female reproductive system is given special attention. A high number of vessels in tumors often indicates a poor prognosis. Extensive research is being conducted on the influence of various factors on angiogenesis initiation and the possibility of suppressing angiogenesis signals to slow down tumor growth. Pharmacological suppression of tumor vessel formation shows promising clinical outcomes but is accompanied by severe side effects. The significant amount of research on tumor vascularization highlights the increasing importance of this area in oncology. However, there is still limited research on the differences in angiogenesis and vessel number between different parts of tumors, as well as between primary tumor nodes and metastases. Further refinement of the results is needed. It has been noted that the expression of proangiogenic factors is usually higher in metastases than in the primary source, and higher in lymphogenous metastases compared to hematogenous ones.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Oncology
Wenwen Zhou, Longtao Yang, Lin Nie, Hui Lin
Summary: Inflammatory mediators in the tumor microenvironment play a critical role in influencing cancer occurrence, growth, and metastasis. Excessive inflammation is closely associated with increased cancer risk and mortality, partly through inflammation-induced angiogenesis. The complex signaling networks involved in inflammation-induced angiogenesis provide potential targets for the design of anti-inflammatory treatments and drugs that inhibit tumor growth.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Eun-A. Kwak, Tasmia Ahmed, Paola Cruz Flores, Hannah R. Ortiz, Paul R. Langlais, Karthikeyan Mythreye, Nam Y. Lee
Summary: The study discovered that beta(IV)-spectrin is a powerful regulator of tumor angiogenesis, and loss of endothelial cell-specific beta(IV)-spectrin can significantly promote tumor growth and metastasis.
Article
Agriculture, Multidisciplinary
Yanfei Tang, Shengtao Yang, Liyuan Lin, Zhaowan Zheng, Shengli Sun, Chunxia Zhou, Pengzhi Hong, Zhong-Ji Qian
Summary: This study evaluated the mechanism of action of pentapeptides derived from Isochrysis zhanjiangensis on inflammation and tumor angiogenesis. The results showed that these pentapeptides effectively inhibited the invasion and migration of endothelial cells and tumor cells, as well as regulated specific signaling pathways and molecular expression.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Yanfei Tang, Shengtao Yang, Liyuan Lin, Zhaowan Zheng, Shengli Sun, Chunxia Zhou, Pengzhi Hong, Zhong-Ji Qian
Summary: This study evaluated the mechanism of action of isolated pentapeptides from Isochrysis zhanjiangensis on inflammation and tumor angiogenesis. The results showed that these pentapeptides effectively inhibited cell invasion and migration by downregulating the expression of specific proteins, and achieved anti-inflammatory and anti-tumor angiogenesis effects through the regulation of multiple signaling pathways.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Cell Biology
Yuan Gu, Maximilian A. Becker, Luisa Mueller, Katharina Reuss, Frederik Umlauf, Tianci Tang, Michael D. Menger, Matthias W. Laschke
Summary: Tumor endothelial cells (TECs) are crucial for tumor angiogenesis, growth and metastasis, and small non-coding microRNAs (miRNAs) play a significant role in regulating TEC function and blood vessel formation. This review provides an overview of the regulatory mechanisms and effects of endothelial miRNAs, highlighting their involvement in fundamental angiogenesis-related signaling pathways. Targeting endothelial miRNAs represents a potential strategy for anti-angiogenic cancer therapy, but further research is needed to understand their networks and develop specific delivery technologies.
Review
Oncology
Jing Liang, Shouqi Wang, Guowei Zhang, Baoyu He, Qingli Bie, Bin Zhang
Summary: Studying the differences, heterogeneity, and interaction of tumor-specific endothelial cells (TECs) with the tumor microenvironment is crucial for developing specific anti-tumor angiogenesis therapies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Peripheral Vascular Disease
Xixiang Tang, Joshua J. Wang, Jinli Wang, Hanna E. Abboud, Yanming Chen, Sarah X. Zhang
Summary: Nox4, a major isoform of NADPH oxidases, plays a crucial role in retinal vascular development and pathological angiogenesis by regulating VEGF/VEGFR2 and angiopoietin-2/integrin alpha V/ERK pathways. Targeting endothelial Nox4 in ischemic/hypoxic retinal diseases should be approached with caution.
Article
Cell & Tissue Engineering
Sihao He, Tianyong Hou, Jiangling Zhou, Qiuchi Ai, Ce Dou, Fei Luo, Jianzhong Xu, Junchao Xing
Summary: In the inflammatory microenvironment, mesenchymal stem cells (MSCs) migrate towards endothelial cells (ECs) via the PDGF-BB/PDGFR β signaling pathway, dependent on the downstream Src-Akt signal pathway.
STEM CELLS INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
