期刊
CELL ADHESION & MIGRATION
卷 5, 期 4, 页码 366-372出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.5.4.17524
关键词
Drosophila; tumor microenvironment; tumor immunology; scribble; TNF
类别
资金
- Cancer Research UK
Metastasis is the most deadly phase of cancer progression, during which cells detach from their original niche to invade distant tissues, yet the biological processes underlying the spread of cancer are still poorly understood. The fruit fly Drosophila melanogaster provides important insights in our understanding of how epithelial cells migrate from their original location and find their way into surrounding and distant tissues in the metastatic process. Here we review recent studies on the mechanisms of migration of embryonic hemocytes, the macrophage-like immuno-surveillance cells, during normal development and wound healing. We highlight the interesting finding that hydrogen peroxide (H2O2) has been identified as the driving force for hemocyte chemotaxis. We also give a special emphasis to studies suggesting the concept that hemocytes, together with the tumor microenvironment, act as potential inducers of the epithelial delamination required for tumor invasion. We propose that cell delamination and migration could be uncoupled from loss of cell polarity via a tumor-related inflammatory response.
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