期刊
CELL ADHESION & MIGRATION
卷 3, 期 2, 页码 167-170出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cam.3.2.7576
关键词
ArgBP2; pancreatic cancer; SoHo family of proteins; adapter protein; CAP/ponsin; vinexin; cell signaling; actin cytoskeleton; adhesion; migration
类别
ArgBP2, a member of the SoHo family of adapter proteins, is a regulator of actin-dependent processes such as cell adhesion and migration. Recent data from our lab revealed that by regulating adhesion and migration of pancreatic cancer cells, ArgBP2 is endowed with an anti-tumoral function. We could show that part of the molecular mechanism involved the interaction of ArgBP2 with the Arp2/3 activator WAVE1, the tyrosine phosphatase PTP-PEST, and the tyrosine kinase c-Abl. As ArgBP2 shares common structural organization and overlapping functions with the two other members of this protein family, CAP and Vinexin, it raises the question whether these two other proteins could also be involved in cancer diseases. The control of cell migration being an important issue in tumor treatment, these recent findings suggest that ArgBP2 family-dependent signaling pathways represents potential targets for the development of therapeutic strategies, and highlight the importance of elucidating their molecular mechanisms of cytoskeletal regulation.
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