Copper-dienamine catalysis: γ-oxyamination of α,β-unsaturated aldehydes

A multicatalytic system composed of copper complexes and sec-amine compounds is proposed for gamma-oxyamination of alpha,beta-unsaturated aldehydes. Using copper complexes in dienamine catalysis expands the scope of the reaction to include TEMPO radicals.Furthermore copper catalysts oxidize allylic alcohols to form alpha,beta-unsaturated aldehydes enabling the one-pot oxidation/oxyamination of allylic alcohols.