Review
Urology & Nephrology
Yanish Soorojebally, Yann Neuzillet, Mathieu Roumiguie, Pierre-Jean Lamy, Yves Allory, Francoise Descotes, Sophie Ferlicot, Diana Kassab-Chahmi, Stephane Oudard, Xavier Rebillard, Catherine Roy, Thierry Lebret, Morgan Roupret, Francois Audenet
Summary: This systematic review evaluated the clinical validity and utility of eleven urinary biomarkers for bladder cancer diagnosis and NMIBC follow-up. The results suggested that urinary biomarkers may have a complementary role in bladder cancer diagnosis and NMIBC surveillance, but further confirmation of their clinical benefit is needed.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Health Care Sciences & Services
Murat Can Karaburun, Mehmet Fatih Ozkaya, Berrin Imge Erguder, Evren Suer
Summary: The study investigates the predictive capability of the Sysmex automated urine-analyzer's atypical-cell parameter compared to cytology and pathology data in the follow-up of NMIBC patients. Clinical data from 273 patients who underwent cystoscopic examination were prospectively collected. The atypical-cell parameter showed promising results in predicting oncological outcomes and could potentially be used in surveillance of NMIBC patients. Multi-center studies with larger patient populations are needed to further validate its efficacy.
JOURNAL OF MEDICAL SYSTEMS
(2023)
Review
Oncology
Felice Crocetto, Biagio Barone, Matteo Ferro, Gian Maria Busetto, Evelina La Civita, Carlo Buonerba, Giuseppe Di Lorenzo, Daniela Terracciano, Jack A. Schalken
Summary: Bladder cancer is the most common malignancy of the urinary tract. Traditional diagnostic methods are invasive and uncomfortable, while alternative methods have poor sensitivity. Therefore, an improved non-invasive approach is needed for the management of bladder cancer.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Oncology
Vittorio Fasulo, Marco Paciotti, Massimo Lazzeri, Roberto Contieri, Paolo Casale, Alberto Saita, Giovanni Lughezzani, Pietro Diana, Nicola Frego, Pier Paolo Avolio, Piergiuseppe Colombo, Grazia Maria Elefante, Giorgio Guazzoni, Nicolo Maria Buffi, Michael Bates, Rodolfo Hurle
Summary: The study found that longitudinally repeating the Xpert BC Monitor assay can significantly reduce the number of unnecessary cystoscopies and urine cytology during follow-up.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Makito Miyake, Nobutaka Nishimura, Sayuri Ohnishi, Yuki Oda, Takuya Owari, Kenta Ohnishi, Yosuke Morizawa, Shunta Hori, Daisuke Gotoh, Yasushi Nakai, Kazumasa Torimoto, Tomomi Fujii, Nobumichi Tanaka, Kiyohide Fujimoto
Summary: This study investigated the potential diagnostic and prognostic values of urine Nectin-2 and Nectin-4 in bladder cancer (BCa). The results showed that urine Nectin-4 levels were significantly higher than Nectin-2 levels. Both Nectin-2 and Nectin-4 had higher sensitivity than cytology for diagnosing BCa.
Article
Medicine, General & Internal
Fee-Wai Chin, Huzlinda Hussin, De-Ming Chau, Teng-Aik Ong, Rosna Yunus, Azad Hassan Abdul Razack, Khatijah Yusoff, Soon-Choy Chan, Abhi Veerakumarasivam
Summary: This study aimed to analyze the protein expression of HOXA13 and HOXB13 genes in Malaysian bladder cancer patients and characterize their features. The results showed that high expression of HOXA13 was significantly associated with non-muscle invasive bladder cancer, lower tumor grade, higher number of lymph node metastases, and recurrence risk. In contrast, low expression of HOXB13 was significantly associated with muscle-invasive bladder cancer, higher tumor stage, tumor grade, and metastatic risk. The expression of HOXA13 and HOXB13 proteins were closely associated with bladder tumorigenesis, suggesting their potential as biomarkers in bladder cancer.
Article
Cell Biology
Xian-Feng Wang, Sheng-An Yang, Shangyu Gong, Chih-Hsuan Chang, Juan Martin Portilla, Deeptiman Chatterjee, Jerome Irianto, Hongcun Bao, Yi-Chun Huang, Wu-Min Deng
Summary: This study shows that upregulation of the Notch signaling pathway induces polyploid mitosis in tumor cells in a Drosophila solid-tumor model, and DNA-damage response genes are upregulated in these tumors and required for ploidy-reduction division. These findings suggest that polyploidy and associated cell-cycle variants play a critical role in increasing tumor-cell heterogeneity and genome instability during cancer progression.
DEVELOPMENTAL CELL
(2021)
Article
Genetics & Heredity
Jieping Yang, Jiaxing Lin, Jun An, Yongkang Zhao, Siyang Jing, Meng Yu, Yuyan Zhu, Yang Yao
Summary: High expression of TRIB3 is associated with poor prognosis in bladder cancer, positively correlated with stage and grade. Down-regulation of TRIB3 expression significantly inhibits growth, migration and cell cycle of bladder cancer cells.
FRONTIERS IN GENETICS
(2021)
Review
Oncology
Karuna Mittal, Jaspreet Kaur, Meghan Jaczko, Guanhao Wei, Michael S. Toss, Emad A. Rakha, Emiel Adrianus Maria Janssen, Havard Soiland, Omer Kucuk, Michelle Dian Reid, Meenakshi V. Gupta, Ritu Aneja
Summary: This article discusses the prevalence of centrosome amplification (CA) in various solid cancers, as well as the utility of quantifying amplified centrosomes as an independent prognostic marker. It also reviews the progression of CA in breast cancer and the potential role of CA in promoting tumor progression and metastasis.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Medicine, General & Internal
Kaoru Murakami, Ian Pagano, Hideki Furuya, Timothy Daskivich, Dave Mori, Charles J. Rosser
Summary: This study examined the impact of Oncuria(TM) on physicians' diagnostic behavior in cases of microhematuria, gross hematuria, and bladder cancer surveillance. The results showed that over 90% of urologists changed their diagnostic behavior in at least one patient case after receiving Oncuria(TM) results. The total number of diagnostic procedures was reduced by 31% for negative Oncuria(TM) tests and 27% for positive Oncuria(TM) tests. This pilot study has the potential to provide insights for our four large multicenter international studies deploying Oncuria(TM).
Article
Biochemistry & Molecular Biology
Despoina D. Gianniou, Aimilia D. Sklirou, Maria-Alexandra Papadimitriou, Katerina-Marina Pilala, Konstantinos Stravodimos, Margaritis Avgeris, Andreas Scorilas, Ioannis P. Trougakos
Summary: This study investigated the expression and role of HSPB2 and HSPB3 genes in bladder cancer patients and bladder cancer cells. The results showed increased expression levels of HSPB2 and HSPB3 genes and proteins in high-grade bladder cancer cells. In clinical samples, the expression levels of HSPB2 and HSPB3 genes were significantly downregulated in bladder tumors but showed an upregulation trend in muscle-invasive and high-grade tumors. These findings suggest that HSPB2 and HSPB3 have a pro-survival role in advanced bladder cancer and can be targeted as novel molecular markers for treatment optimization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Konstantinos Christos Liosis, Ahmed Al Marouf, Jon G. Rokne, Sunita Ghosh, Tarek A. Bismar, Reda Alhajj
Summary: Cancer is a major cause of death, and biomarkers are crucial for identifying the genomic reasons behind it. This paper examines genomic data of bladder cancer using various bioinformatics methods, leading to discovery of two gene signatures capable of predicting therapy response and disease progression with considerable accuracy.
Article
Oncology
Takashi Yokoyama, Makoto Toguchi, Junpei Iizuka, Shigeru Horita, Tsutomu Ishizuka, Yu Chu-Su, Yoji Nagashima, Toshio Takagi, Kazunari Tanabe, Yoshikazu Tokuoka
Summary: This study proposed a protocol that utilizes ALA-PpIX staining and ImageJ analysis to enhance the accuracy of urine cytology analysis.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Oncology
Uwe Bieri, Dominik Enderlin, Lorenz Buser, Marian S. Wettstein, Daniel Eberli, Holger Moch, Thomas Hermanns, Cedric Poyet
Summary: This study evaluated the value of a modified Immunoscore as a predictive marker for the prognosis of non-muscle-invasive bladder cancer. The findings suggest that the modified Immunoscore can accurately predict the prognosis of high-risk patients and guide the allocation of follow-up or treatment strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Nora Jee-Young Park, Yeseul Choi, Donghyeon Lee, Ji young Park, Jong Mi Kim, Yoon Hee Lee, Dae Gy Hong, Gun Oh Chong, Hyung Soo Han
Summary: Cervical cancer is a significant global health issue, especially in developing countries. This study identified potential biomarkers for early detection of cervical lesions using transcriptomic analysis. These findings have important clinical implications for improving cervical cancer screening.
CANCER GENOMICS & PROTEOMICS
(2023)
Article
Urology & Nephrology
Koji Shiraishi, Seiji Kitahara, Hideaki Ito, Kazuo Oba, Chietaka Ohmi, Hideyasu Matsuyama
INTERNATIONAL JOURNAL OF UROLOGY
(2019)
Meeting Abstract
Oncology
Hiroaki Matsumoto, Kazuhiro Nagao, Masahiro Samoto, Junichi Mori, Kosuke Shimizu, Ryo Inoue, Yoshiaki Yamamoto, Seiji Yano, Hiroshi Hirata, Tomoyuki Shimabukuro, Hideyasu Matsuyama
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Meeting Abstract
Oncology
Junichi Inokuchi, Kentaro Kuroiwa, Hiroyuki Nishiyama, Takahiro Kojima, Yoshiyuki Kakehi, Mikio Sugimoto, Toshiki Tanikawa, Hiroyuki Fujimoto, Momokazu Gotoh, Naoya Masumori, Osamu Ogawa, Masatoshi Eto, Chikara Ohyama, Akito Yamaguchi, Hideyasu Matsuyama, Tomohiko Ichikawa, Keiichi Ito, Junki Mizusawa, Junko Eba, Seiji Naito
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Oncology
Shuji Mikami, Ryuichi Mizuno, Tsunenori Kondo, Nobuo Shinohara, Norio Nonomura, Seiichiro Ozono, Masatoshi Eto, Katsunori Tatsugami, Tatsuya Takayama, Hideyasu Matsuyama, Takeshi Kishida, Mototsugu Oya
Article
Pharmacology & Pharmacy
Yoshiaki Yamamoto, Toru Otori, Ryo Inoue, Seiji Yano, Hiroshi Hirata, Hiroaki Matsumoto, Kenji Matsuyama, Hideyasu Matsuyama
JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Urology & Nephrology
Koji Shiraishi, Masanori Tabara, Hideyasu Matsuyama
JOURNAL OF UROLOGY
(2020)
Article
Oncology
Masaki Shiota, Naohiro Fujimoto, Yoshiaki Yamamoto, Ario Takeuchi, Katsunori Tatsugami, Takeshi Uchiumi, Hideyasu Matsuyama, Masatoshi Eto
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Urology & Nephrology
Kimihiko Nakamura, Yudai Nagata, Toshiya Hiroyoshi, Naohito Isoyama, Koki Fujikawa, Yutaka Miura, Hideyasu Matsuyama, Makoto Kuro-o
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2020)
Article
Oncology
Atsushi Ikeda, Takahiro Kojima, Koji Kawai, Shiro Hinotsu, Naoto Keino, Kenichiro Shiga, Hideaki Miyake, Yasuyoshi Miyata, Yutaka Enomoto, Fumitaka Shimizu, Satoshi Anai, Hideyasu Matsuyama, Chieko Suzuki, Yusuke Kanimoto, Keisuke Shigeta, Seiji Naito, Hideyuki Akaza, Hiroyuki Nishiyama
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Immunology
Yuki Nakayama, Naohito Isoyama, Takeshi Yamamoto, Yudai Nagata, Masafumi Matsumura, Koki Fujikawa, Hideyasu Matsuyama, Koji Shiraishi
TRANSPLANT IMMUNOLOGY
(2020)
Article
Medicine, General & Internal
Makito Miyake, Nagaaki Marugami, Yuya Fujiwara, Kazumasa Komura, Teruo Inamoto, Haruhito Azuma, Hiroaki Matsumoto, Hideyasu Matsuyama, Kiyohide Fujimoto
Article
Oncology
Makito Miyake, Hideyasu Matsuyama, Satoshi Teramukai, Fumie Kinoshita, Isao Yokota, Hiroaki Matsumoto, Keiji Shimada, Mitsuru Kinjyo, Tatsuro Shimokama, Koji Okumura, Masaya Yomenori, Hideki Enokida, Masayuki Nakagawa, Yasushi Nakai, Kiyohide Fujimoto
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Yoshiaki Yamamoto, Hideyasu Matsuyama, Hiroaki Matsumoto, Shigeru Sakano, Nakanori Fuji, Kazuo Oba, Mitsutaka Yamamoto, Yoriaki Kamiryo, Takeshi Hiragino, Kazuhiro Nagao, Kimio Takai, Akihiko Aoki
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Kazuhiro Suzuki, Nobuaki Matsubara, Hirotaka Kazama, Takeshi Seto, Shoko Tsukube, Hideyasu Matsuyama
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2019)
Review
Obstetrics & Gynecology
Koji Shiraishi, Hideyasu Matsuyama
REPRODUCTIVE MEDICINE AND BIOLOGY
(2019)