期刊
CANCER DISCOVERY
卷 3, 期 5, 页码 497-501出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-13-0059
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- NCI NIH HHS [R01 CA175727] Funding Source: Medline
- NIDDK NIH HHS [DK088190-01A1, R01 DK088190] Funding Source: Medline
- NIGMS NIH HHS [R01 GM093072, GM093072-01] Funding Source: Medline
Mitochondrial metabolism influences histone and DNA modifications by retrograde signaling and activation of transcriptional programs. Considering the high number of putative sites for acetylation and methylation in chromatin, we propose in this perspective article that epigenetic modifications might impinge on cellular metabolism by affecting the pool of acetyl-CoA and S-adenosylmethionine. Cancer Discov; 3(5); 497-501. (C) 2013 AACR.
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