期刊
CANCER DISCOVERY
卷 2, 期 7, 页码 582-585出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/2159-8290.CD-12-0212
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- Howard Hughes Medical Institute Funding Source: Medline
- NCI NIH HHS [R21 CA155992, R01 CA132874, P50CA69568, R01CA132874, P50 CA069568, R21CA155992, U01 CA111275, UO1 CA111275] Funding Source: Medline
Using a series of detailed experiments, Zhang and colleagues establish that the prostate cancer RNA chimera SLC45A3-ELK4 is generated by cis-splicing between the 2 adjacent genes and does not involve DNA rearrangements or trans-splicing. The chimera expression is induced by androgen treatment likely by overcoming the read-through block imposed by the intergenic CCCTC insulators bound by CCCTC-binding factor repressor protein. The chimeric transcript, but not wild-type ELK4, is shown to augment prostate cancer cell proliferation. Cancer Discov; 2(7); 582-5. (C) 2012 AACR.
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