Review
Multidisciplinary Sciences
Wei Zhang, Yun Tang, Huan Liu, Li ping Yuan, Chu chu Wang, Shu fan Chen, Jin Huang, Xin yuan Xiao
Summary: Most ICU-AW risk prediction models show good efficacy for high-risk groups, but there is bias in their development and verification processes. Large-sample, multi-center studies are needed in the future to provide a reliable basis for ICU-AW risk prediction models.
Review
Multidisciplinary Sciences
Kazuaki Naya, Gen Aikawa, Akira Ouchi, Mitsuki Ikeda, Ayako Fukushima, Shuhei Yamada, Megumi Kamogawa, Shun Yoshihara, Hideaki Sakuramoto
Summary: Second victim syndrome is prevalent among intensive care unit healthcare workers, with 58% experiencing this condition. Common symptoms include guilt, anxiety, self-blame, and reduced self-confidence. Approximately 20% of individuals take more than a year or do not recover at all from this syndrome.
Review
Nursing
Charlotte C. Maartmann-Moe, Marianne Trygg Solberg, Marie Hamilton Larsen, Simen A. Steindal
Summary: This study conducted a qualitative systematic review and meta-synthesis to identify and synthesize evidence of adult patients' memories from their stay in the intensive care unit. Three main themes emerged from the review, including surreal dreams and delusions, varied care experiences, and memories of vulnerability and near-death experiences.
Review
Public, Environmental & Occupational Health
Alireza Nikbakht Nasrabadi, Soheila Abbasi, Abbas Mardani, Maryam Maleki, Zeljko Vlaisavljevic
Summary: This study aims to synthesize the experiences of ICU nurses working with COVID-19 patients. The findings suggest that healthcare authorities and policymakers can facilitate the provision of high-quality patient care during the COVID-19 pandemic through appropriate planning to provide adequate support and training, prevent shortages of nursing staff and equipment, and provide adequate attention to the psychological needs and job satisfaction of ICU nurses.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Public, Environmental & Occupational Health
Josephine Henry Basil, Chandini Menon Premakumar, Adliah Mhd Ali, Nurul Ain Mohd Tahir, Noraida Mohamed Shah
Summary: This is the first comprehensive systematic review and meta-analysis estimating the prevalence, causes, and severity of medication administration errors (MAEs) among neonates. There is a need to improve the quality and reporting of studies to produce a better estimate of the prevalence of MAEs among neonates. Important targets have been identified to guide the implementation of remedial measures.
Review
Critical Care Medicine
Kirstine N. la Cour, Nina C. Andersen-Ranberg, Sarah Weihe, Lone M. Poulsen, Camilla B. Mortensen, Cilia K. W. Kjer, Marie O. Collet, Stine Estrup, Ole Mathiesen
Summary: Hypoactive delirium is the most common motor subtype in critically ill patients. Mixed delirium has the worst outcomes and receives more pharmacological interventions compared to other subtypes. Standardization in delirium research is needed.
Review
Health Care Sciences & Services
A. C. M. Brekelmans, Dharmanand Ramnarain, Sjaak Pouwels
Summary: This review examines the psychological impact on relatives of deceased ICU patients. The study found that a bereavement strategy consisting of a communication strategy and a brochure can reduce the appearance of symptoms of PTSD, anxiety, and depression. The use of a brochure, condolence card, and phone call as bereavement support can lower the risk of prolonged grief.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Public, Environmental & Occupational Health
Buddhika P. K. Mahesh, John D. Hart, Ajay Acharya, Hafizur Rahman Chowdhury, Rohina Joshi, Tim Adair, Riley H. Hazard
Summary: Verbal autopsy (VA) is an effective method for assigning cause of death, but validation studies may have inconsistencies in methodologies and use poor quality comparison cause of death data. Future VA validation studies should adhere to consistent methodological criteria for policymakers to interpret findings accurately.
Review
Nutrition & Dietetics
Aileen Hill, Gunnar Elke, Arved Weimann
Summary: Nutritional therapy for critically ill patients should be tailored to individual patients, focusing on the phase of critical illness, metabolic tolerance, leading symptoms, and comorbidities. Personalized and disease-specific nutritional therapy in the ICU requires an interdisciplinary approach and frequent reevaluation for optimal clinical outcomes.
Review
Infectious Diseases
Bruno Viaggi, Alice Cangialosi, Martin Langer, Carlo Olivieri, Andrea Gori, Alberto Corona, Stefano Finazzi, Antonello Di Paolo
Summary: The clinical outcome of severe infections in ICU patients depends on multiple factors, including early administration of chemotherapies and comorbidities. Different antibacterial drugs have variable tissue penetration rates, and the correlation between plasma and tissue concentrations may be inconsistent. This review focuses on antibacterial drugs that act as protein synthesis inhibitors and disrupt DNA structure and function. It found that fluoroquinolones, macrolides, linezolid, and tigecycline have excellent diffusion into epithelial lining fluid, which is crucial for the treatment of ventilator and healthcare-associated pneumonia. Some drugs also show high penetration rates in cerebrospinal fluid, skin, and soft tissues. Further studies are needed to improve understanding of drug tissue penetration, especially in the presence of factors that may affect drug pharmacokinetics.
Review
Infectious Diseases
Stefano Finazzi, Giacomo Luci, Carlo Olivieri, Martin Langer, Giulia Mandelli, Alberto Corona, Bruno Viaggi, Antonello Di Paolo
Summary: The diffusion of antimicrobial drugs within tissues is crucial for treating infections in critically ill patients. However, the unique physiopathology of these patients can significantly affect the pharmacokinetics of drugs and their distribution in the body. This review explores the tissue distribution of beta-lactams and other antimicrobials in critically ill patients, finding that the passage of drugs within tissues varies greatly and there is a large interindividual variability. Off-label dosing regimens may be an effective solution to overcome these challenges.
Article
Immunology
Jing-Jiang Zhou, Wei-Chao Ding, Yan-Cun Liu, Yu-Lei Gao, Lei Xu, Run-Lu Geng, Ying Ye, Yan-Fen Chai
Summary: This study evaluated the diagnostic performance of metagenomic next-generation sequencing (mNGS) and culture in detecting pathogens in patients with suspected pulmonary infection. The results showed that mNGS had a significantly higher positive detection rate than culture, indicating its value as a tool for identifying pathogens, especially in ICU patients who are more prone to mixed infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Nursing
Weijing Sui, Xiaoyan Gong, Xiaoting Qiao, Lixin Zhang, Junning Cheng, Jing Dong, Yiyu Zhuang
Summary: This study examines and synthesizes the qualitative data on family members' perceptions of surrogate decision-making in the intensive care unit. The findings reveal that individuals undergo complex emotional and cognitive processes during surrogate decision-making, and families as a whole experience different processes and outcomes. Furthermore, the decision-making process reflects society's perceptions of the medical system.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2023)
Review
Multidisciplinary Sciences
Lichen Ouyang, Muqing Yu, Yan Zhu, Jie Gong
Summary: A systematic review of 40 studies involving 15320 COVID-19 patients revealed varying rates of IMV application in different continents, with higher mortality in patients treated with IMV compared to non-IMV respiratory support.
Review
Pediatrics
Jessica Qing Hui Wong, Judith Sharon Charles, Hao Ting Mok, Teresa Shu Zhen Tan, Zubair Amin, Yvonne Peng Mei Ng
Summary: This study synthesized qualitative research on the experiences of healthcare personnel in the neonatal intensive care unit (NICU) caring for dying neonates. It found that healthcare personnel face many challenges and pressures when faced with neonatal death, including discomfort with neonatal deaths, poor communication among healthcare personnel and with patient's family, lack of support, and emotional responses. Healthcare personnel can provide better end-of-life care by understanding and overcoming these distressing factors.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Behavioral Sciences
Elham A. Yousef, Kathleen M. Sutcliffe, Kathryn M. McDonald, David E. Newman-Toker
Summary: This study applies the high-reliability organization (HRO) paradigm to the diagnostic process, outlining challenges and solutions. Multiple challenges are identified, but it is pointed out that these challenges are not insurmountable. The conclusion suggests that the HRO perspective can improve the safety of the diagnostic process, and the proposed ideas can be implemented by both individual clinicians and healthcare leaders for systematic progress in enhancing diagnostic performance.
Article
Emergency Medicine
Ava L. Liberman, Ahmed Hassoon, Mehdi Fanai, Shervin Badihian, Hetal Rupani, Susan M. Peterson, Krisztian Sebestyen, Zheyu Wang, Yuxin Zhu, Richard B. Lipton, David E. Newman-Toker
Summary: This study found that 0.6% of patients with emergency department visits for headaches were subsequently hospitalized for cerebrovascular disease, often at a different medical center. Patients with a history of stroke or neurosurgery prior to the visit may represent important opportunities for cerebrovascular disease prevention. Poor documentation of neurological examinations among cases suggests a potential need for improvement in emergency department processes.
ACADEMIC EMERGENCY MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sagar B. Dave, Kristopher B. Deatrick, Samuel M. Galvagno, Michael A. Mazzeffi, David J. Kaczorowski, Ronson J. Madathil, Raymond Rector, Ali Tabatabai, Daniel J. Haase, Daniel Herr, Thomas M. Scalea, Jay Menaker
Summary: This study investigated the causes and timing of in-hospital mortality in patients supported with VV ECMO. It found that most deaths occurred prior to lung recovery and decannulation, with the most common cause being removal of life sustaining therapy in the setting of multisystem organ failure. Older age and worse predictive mortality scores were associated with non-survival.
Article
Medicine, General & Internal
Tzu-Pu Chang, Anand K. Bery, Zheyu Wang, Krisztian Sebestyen, Yu-Hung Ko, Ava L. Liberman, David E. Newman-Toker
Summary: This study compared stroke hospitalizations in general care vs. specialty care settings for patients with purportedly benign dizziness, finding a higher short-term stroke risk in general care and no significant difference in long-term risk, indicating higher misdiagnosis-related harms in general care.
Article
Medicine, General & Internal
Michael Ellenbogen, Laura Prichett, David E. Newman-Toker, Daniel J. Brotman
Summary: By analyzing the hospital-level diagnostic overuse index and quality metrics, no significant relationship between diagnostic intensity and quality of care was found. This suggests that targeted efforts to reduce diagnostic overuse in hospitals may not adversely impact the quality of care.
Article
Cardiac & Cardiovascular Systems
Sagar B. Dave, Ronald Rabinowitz, Aakash Shah, Ali Tabatabai, Samuel M. Galvagno, Michael A. Mazzeffi, Raymond Rector, David J. Kaczorowski, Thomas M. Scalea, Jay Menaker
Summary: This study compares the outcomes of VV ECMO treatment in COVID-19 patients and non-COVID-19 viral infection patients. The results show that COVID-19 patients have a higher mortality rate, but survivors have longer duration of VV ECMO use and similar hospital length of stay.
Article
Clinical Neurology
Ava L. Liberman, Cenai Zhang, Richard B. Lipton, Hooman Kamel, Neal S. Parikh, Babak B. Navi, Alan Z. Segal, Junaid Razzak, David E. Newman-Toker, Alexander E. Merkler
Summary: Patients discharged to home after an emergency department visit for headache face a heightened risk of stroke, three to four times higher than the risk associated with renal colic or back pain.
Article
Cardiac & Cardiovascular Systems
Elizabeth K. Powell, Allison S. Lankford, Mira Ghneim, Joseph Rabin, Daniel J. Haase, Siamak Dahi, Kristopher B. Deatrick, Eric Krause, Gregory Bittle, Samuel M. Galvagno, Thomas Scalea, Ali Tabatabai
Summary: Lower PRESET scores are associated with improved survival in COVID-19 VV ECMO patients. The incorporation of PRESET-Score into institutional ECMO candidacy guidelines may help ensure access to this limited healthcare resource for all critically ill patients.
Correction
Emergency Medicine
Jeffrey J. Perry, David E. Newman-Toker, Robert Ohle
CANADIAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Clinical Neurology
Alexander A. Tarnutzer, Daniel Gold, Zheyu Wang, Karen A. Robinson, Jorge C. Kattah, Georgios Mantokoudis, Ali S. Saber Tehrani, David S. Zee, Jonathan A. Edlow, David E. Newman-Toker
Summary: This study assessed the accuracy of bedside findings in differentiating peripheral vestibular from central neurologic causes. The HINTS eye movement battery had high sensitivity and specificity for stroke diagnosis. These findings suggest that HINTS examination should be disseminated to all clinicians evaluating dizziness/vertigo.
ANNALS OF NEUROLOGY
(2023)
Article
Emergency Medicine
Melissa A. Kelly, Luis M. Pinet-Peralta, Tara M. Roque, Thomas M. Scalea, Theodore R. Delbridge, Samuel M. Galvagno
Summary: This article describes the implementation of a state-wide Critical Care Coordination Center (C4) in Maryland, USA, which ensures timely and equitable access to critical care. The C4 played an integral role during the COVID-19 pandemic and can serve as a model for other regions to adopt.
PREHOSPITAL AND DISASTER MEDICINE
(2023)
Article
Medicine, General & Internal
Ava L. Liberman, Zheyu Wang, Yuxin Zhu, Ahmed Hassoon, Justin Choi, J. Matthew Austin, Michelle C. Johansen, David E. Newman-Toker
Summary: This study aims to clarify the use of the Symptom-Disease Pair Analysis of Diagnostic Error (SPADE) method to ensure valid results. The study discusses four different types of comparators and the logic behind choosing one over the other, as well as the inferences that can be drawn from comparative analysis. The aim is to improve the validity of SPADE and related approaches to quantifying diagnostic errors in medicine.
Review
Emergency Medicine
Christie L. Fritz, Sarah Alice Thomas, Samuel M. Galvagno, Stephen H. Thomas
Summary: Helicopter EMS (HEMS) is considered appropriate for severely injured patients with ISS >15, but this study aimed to evaluate the mortality benefit of HEMS for patients with ISS >8. The results showed a significant survival benefit for patients with ISS >8 when HEMS was used over traditional ambulance transportation.
PREHOSPITAL EMERGENCY CARE
(2023)
Article
Health Care Sciences & Services
David E. Newman-Toker, Najlla Nassery, Adam C. Schaffer, Chihwen Winnie Yu-Moe, Gwendolyn D. Clemens, Zheyu Wang, Yuxin Zhu, Ali S. Saber Tehrani, Mehdi Fanai, Ahmed Hassoon, Dana Siegal
Summary: By combining prior results and rigorous estimates of disease incidence, we estimated that 795,000 Americans become permanently disabled or die annually due to misdiagnosis of dangerous diseases. Just 15 diseases account for about half of all serious harms, suggesting that the problem may be more tractable than previously thought.
BMJ QUALITY & SAFETY
(2023)
Meeting Abstract
Clinical Neurology
Shervin Badihian, David S. Zee, John P. Carey, Ari M. Blitz, Jonathan A. Edlow, Daniel R. Gold, Joshua N. Goldstein, Joanna C. Jen, Jorge C. Kattah, Kevin A. Kerber, Amir Kheradmand, Doris D. M. Lin, William J. Meurer, Rodney Omron, Susan M. Peterson, Richard E. Rothman, Ali S. Tehrani, Adriana Batazzi, Tzu-Pu Chang, Tracey Economas, Vahid Eslami, Vahid Eslami, Joshua Gruber, Meghan Hildreth, Michael Iacobelli, Karen Lane, Nichol Mcbee, Noeleen Ostapkovich, Nana Tevzadze, Ying Wang, Zheyu Wang, Yuxin Zhu, Daniel F. Hanley, David E. Newman-Toker
ANNALS OF NEUROLOGY
(2022)
