Article
Pediatrics
Emma Louise Malchau Carlsen, Kia Hee Schultz Dungu, Anna Lewis, Nadja Hawwa Vissing, Lise Aunsholt, Simon Trautner, Hristo Stanchev, Gholamreza Krog Dayani, Anne-Janet L. Pedersen, Mia Bjerager, Maria De Salas, Kristian Vestergaard, Pernille Pedersen, Niels Frimodt-Moller, Gorm Greisen, Bo Molholm Hansen, Ulrikka Nygaard
Summary: This study evaluated the implementation of switch therapy from intravenous to oral antibiotic treatment in neonates with early-onset infection. The results showed that switch therapy was safe and effective in relieving the treatment burden for neonates, caregivers, and healthcare systems.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Infectious Diseases
Jiao Liu, Yizhu Chen, Ranran Li, Zhixiong Wu, Qianghong Xu, Zhongyi Li, Djillali Annane, Huibin Feng, Sisi Huang, Jun Guo, Lidi Zhang, Xiaofei Ye, Wei Zhu, Hangxiang Du, Yong'an Liu, Tao Wang, Limin Chen, Zhenliang Wen, Jean-Louis Teboul, Dechang Chen
Summary: This study evaluated the effectiveness of intravenous immunoglobulin (IVIG) treatment in severe COVID-19 patients and found that it did not significantly reduce 28-day mortality. Apart from prone position ventilation, there were no significant differences in other clinical outcomes between the IVIG group and the non-IVIG group.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Review
Pediatrics
Alanoud Aljarbou, Carlos Cuello, Ana Teresa Figueiredo Stochero Leslie
Summary: This study aimed to evaluate the efficacy and harms of a short duration (7-10 days) compared with a standard duration (10-14 days) of antibiotics in treating culture-proven neonatal sepsis. The study included five trials conducted in India and found that the short-term antibiotics regimen may shorten the duration of hospitalisation by 4 days, but evidence for other outcomes was very uncertain.
Article
Critical Care Medicine
Tim Rahmel, Felix Kraft, Helge Haberl, Ute Achtzehn, Timo Brandenburger, Holger Neb, Dominik Jarczak, Maximilian Dietrich, Harry Magunia, Frieda Zimmer, Jale Basten, Claudia Landgraf, Thea Koch, Kai Zacharowski, Markus A. Weigand, Peter Rosenberger, Roman Ullrich, Patrick Meybohm, Axel Nierhaus, Detlef Kindgen-Milles, Nina Timmesfeld, Michael Adamzik
Summary: A retrospective multicentric cohort study found that intravenous IgM-enriched immunoglobulins may have clinically relevant effects in certain subgroups of critically ill patients with COVID-19.
Article
Pediatrics
Asha Reddy, Veeraraja Sathenahalli, Niranjan Shivanna, Naveen Benakappa, Prathik Bandiya
Summary: The study found that 10 days of antibiotics in neonates with culture-positive sepsis, who have achieved clinical and microbiologic remission at day 7, is noninferior to 14 days of therapy. Larger trials are needed to confirm these findings.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Pharmacology & Pharmacy
Nicolas Severino, Soledad Urzua, Mauricio Ibacache, Claudio Paulos, Luis Cortinez, Alberto Toso, Liliana Leguizamon, Rocio Inojosa, Andrea Maccioni, Sebastian Meza, Andres Garcia, Marcelo Ramirez, Catalina Von Mentlen, Javiera Ceballos, Noemi Paredes
Summary: This study aimed to characterize the pharmacokinetic parameters of intravenous amikacin in newborns and assess the impact of sepsis on amikacin exposure. Data from 329 drug assay samples obtained from 116 newborn patients showed that weight, postmenstrual age (PMA), and renal function were key factors influencing amikacin pharmacokinetics in newborns. Additionally, it was found that pathophysiological states such as sepsis and shock had opposite effects on amikacin clearance and should be considered in dose adjustments.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Immunology
Coco R. R. Beudeker, Daniel C. C. Vijlbrief, Joris M. van Montfrans, Suzan H. M. Rooijakkers, Michiel van der Flier
Summary: Neonates, especially preterm neonates, have the highest risk of sepsis due to the immaturity of their immune system. Strategies to improve neonatal host-defense, such as boosting immunity and increasing complement activity, have shown promising results in preclinical studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Bo M. van der Weijden, Niek B. Achten, Jolita Bekhof, Esther E. Evers, Mylene Berk, Arvid W. A. Kamps, Maarten Rijpert, Gavin W. ten Tusscher, Marlies A. van Houten, Frans B. Plotz
Summary: Low adherence to the Dutch guidelines led to the majority of neonates not receiving the recommended antibiotic treatment, while some neonates had prolonged antibiotic use despite negative blood cultures. The guidelines need revision.
Article
Pharmacology & Pharmacy
Giuliana Scarpati, Daniela Baldassarre, Giovanni Tripepi, Massimo Boffardi, Ornella Piazza
Summary: The study found that intravenous IgM-enriched immunoglobulins did not significantly influence the biomarker concentrations in sepsis patients, but may have a reducing effect on Presepsin levels, especially in a younger population. Age was identified as a critical variable in determining the response to Pentaglobin in septic patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Obstetrics & Gynecology
Ying Tze Viola Chan, Steven Yuk Fai Lau, Shuk Yi Annie Hui, Teresa Ma, Choi Wah Kong, Lee Ting Kwong, Diana Chan, Diana Lee, Sau Lan Mok, Vinci Ma, Yim Chong Lo, Kwok Yin Leung, Wing Cheong Leung
Summary: This retrospective cohort study aimed to compare the incidences of early and late-onset neonatal sepsis, including group B streptococcus (GBS) and Escherichia coli (E. coli), before and after the implementation of universal screening and intrapartum antibiotics prophylaxis (IAP). The study found that the implementation of GBS screening and IAP was associated with a reduction in early-onset neonatal sepsis, including GBS disease. There was no significant evidence of an increase in the incidence of late-onset neonatal sepsis, including those caused by GBS.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Microbiology
Nirav Pandya, Yasemin Cag, Nenad Pandak, Abdullah Umut Pekok, Aruna Poojary, Folusakin Ayoade, Teresa Fasciana, Anna Giammanco, Hulya Caskurlu, Dhanji P. Rajani, Yogesh Kumar Gupta, Ilker Inanc Balkan, Ejaz Ahmed Khan, Hakan Erdem
Summary: The study identified significant risk factors for C. auris infection, such as age, history of ICU admission, and diabetes. Source removal and antifungal therapy were associated with a reduction in mortality, highlighting the importance of targeted antifungal therapy and infection control practices in managing C. auris infections.
Article
Medicine, General & Internal
Roelie M. Wosten-van Asperen, Hannah M. la Roi-Teeuw, Rombout B. E. van Amstel, Lieuwe D. J. Bos, Wim J. E. Tissing, Iolanda Jordan, Christian Dohna-Schwake, Gabriella Bottari, John Pappachan, Roman Crazzolara, Rosanna I. Comoretto, Agniezka Mizia-Malarz, Andrea Moscatelli, Maria Sanchez-Martin, Jef Willems, Colin M. Rogerson, Tellen D. Bennett, Yuan Luo, Mihir R. Atreya, E. Vincent S. Faustino, Alon Geva, Scott L. Weiss, Luregn J. Schlapbach, L. Nelson Sanchez-Pinto
Summary: We aimed to determine whether unique, reproducible, and clinically-relevant sepsis phenotypes exist in pediatric cancer patients. Through studying two large multicenter cohorts of pediatric cancer patients, we identified two distinct sepsis phenotypes that were comparable across both cohorts and had prognostic implications.
Article
Cardiac & Cardiovascular Systems
Chetan Shenoy, John D. Grizzard, Dipan J. Shah, Mahwash Kassi, Michael J. Reardon, Marianna Zagurovskaya, Han W. Kim, Michele A. Parker, Raymond J. Kim
Summary: CMR has high diagnostic accuracy in patients with suspected cardiac tumour. Patients with CMR diagnoses of pseudomass and benign tumour have similar long-term mortality to those with no mass. The CMR diagnosis is a powerful independent predictor of mortality, providing incremental prognostic value over clinical risk factors.
EUROPEAN HEART JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Masayuki Akatsuka, Yoshiki Masuda, Hiroomi Tatsumi, Tomoko Sonoda
Summary: This single-center retrospective study found that intravenous immunoglobulin (IVIG) supplementation was associated with improved prognosis in patients with sepsis and low serum immunoglobulin G (IgG) levels. The 28-day and 90-day mortality rates were significantly lower in the IVIG group, and the number of days free from renal replacement therapy was significantly higher in the IVIG group compared with the non-IVIG group.
CLINICAL THERAPEUTICS
(2022)
Article
Dermatology
M. Goebeler, Z. Bata-Csorgo, C. De Simone, B. Didona, E. Remenyik, N. Reznichenko, J. Stoevesandt, E. S. Ward, W. Parys, H. de Haard, P. Dupuy, P. Verheesen, E. Schmidt, P. Joly
Summary: Efgartigimod exhibited good tolerability and significant early disease control effects in treating pemphigus, leading to complete clinical remission in some patients.
BRITISH JOURNAL OF DERMATOLOGY
(2022)