Article
Endocrinology & Metabolism
JunWei Sun, Qi Liu, Huan He, Lanlan Jiang, Kok Onn Lee, Dongmei Li, Jianhua Ma
Summary: This study investigated the association between metformin and bone mineral density (BMD) in Chinese patients with type 2 diabetes mellitus (T2DM). The results showed that metformin use was associated with a lower prevalence of osteoporosis and osteopenia, especially in women. Metformin treatment was independently associated with higher BMD and a lower odds ratio of osteoporosis and low BMD.
DIABETES & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Oliver Christian Rabe, Matilde Winther-Jensen, Kristine Hojgaard Allin, Ole Lander Svendsen
Summary: The study showed that patients with diabetes and Charcot foot have a higher risk of fractures and osteoporosis compared to patients with diabetes without Charcot foot.
Article
Endocrinology & Metabolism
Julien Paccou, Sammy Badr, Daniela Lombardo, Huda Khizindar, Valerie Deken, Stefan Ruschke, Dimitrios C. Karampinos, Anne Cotten, Bernard Cortet
Summary: This study aimed to determine the association between proton density fat fraction (PDFF) and fractures. A case-control study was conducted on postmenopausal women, and it was found that MRI-based measurement of proximal femur PDFF can discriminate between postmenopausal women with and without clinical vertebral fractures, independent of age, CCI, and BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Miroslav Vujasinovic, Lorena Nezirevic Dobrijevic, Ebba Asplund, Wiktor Rutkowski, Ana Dugic, Mashroor Kahn, Ingrid Dahlman, Maria Saaf, Hannes Hagstrom, Johannes-Matthias Lohr
Summary: This study found that only 23% of patients with CP underwent DXA examination, with 53.4% of patients having low BMD. The fracture rate was significantly higher in patients with low BMD compared to those with normal BMD.
Review
Medicine, General & Internal
Athanasios D. Anastasilakis, Polyzois Makras, Julien Paccou, Ilias Bisbinas, Stergios A. Polyzos, Socrates E. Papapoulos
Summary: The management of patients with RVFx requires a multidisciplinary approach, including pain relief, medication administration, back protection, early mobilization, and appropriate exercise.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Se-Won Lee, Younghyun Yoon, Junhyuk Kwon, Jun-Young Heu, Jihyo Hwang
Summary: The clinical significance of BMD discordance between the hip and spine for hip fractures was evaluated in this study. The results showed that the rates of BMD discordance and low hip discordance were significantly higher in the hip fracture group than in the non-fracture group, indicating a higher risk of hip fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Yui Ogiso, Tatsunori Hanai, Kayoko Nishimura, Takao Miwa, Toshihide Maeda, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu
Summary: This cross-sectional study aimed to determine whether TBS can identify patients with liver cirrhosis that are at risk of vertebral fractures. The results showed a significant correlation between TBS and vertebral fractures, indicating that TBS can help identify patients at risk of vertebral fractures in liver cirrhosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Henrik Falhammar, Louise Frisen, Angelica Linden Hirschberg, Agneta Nordenskjold, Catarina Almqvist, Anna Nordenstrom
Summary: Patients with congenital adrenal hyperplasia (CAH) have an increased prevalence of fractures, especially those associated with osteoporosis. This highlights the need for regular assessment of fracture risk and optimization of treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Environmental Sciences
Seyed Rohallah Mousavibaygei, Amir Bisadi, Fariba ZareSakhvidi
Summary: This study systematically reviewed the evidence on the association between exposure to air pollution and osteoporosis-related outcomes. The findings suggest that PM2.5, PM10, and nitrogen dioxide may be associated with decreased bone density, osteoporotic fractures, and osteoporosis. However, due to limitations in the number of studies, heterogeneity, and publication bias, caution should be exercised in interpreting the results.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Rheumatology
Katherine D. Wysham, Joshua F. Baker, Dolores M. Shoback
Summary: RA patients have increased risk for osteoporotic fracture. Factors such as ACPA positivity, glucocorticoid use, poor functional status, and frailty contribute to low BMD and fractures. Tight disease control and biologic therapies may help mitigate fracture risk.
CURRENT OPINION IN RHEUMATOLOGY
(2021)
Article
Endocrinology & Metabolism
Silan Zheng, Jingqi Zhou, Kai Wang, Xinyue Wang, Zhibin Li, Ning Chen
Summary: This study evaluated the associations of obesity indices with bone mineral densities and risk of osteoporosis in type 2 diabetes mellitus patients. It found that higher obesity indices were positively associated with higher bone mineral densities and lower risk of osteoporosis, but the associations varied by the presence of diabetic cardiovascular complications.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Xin Zhao, Jianbin Sun, Sixu Xin, Xiaomei Zhang
Summary: This study analyzed the association between blood lipid metabolism and osteoporosis (OP) in older adults with type 2 diabetes mellitus (T2DM). The results showed that higher levels of low-density lipoprotein cholesterol (LDL-C) were associated with OP, while higher levels of high-density lipoprotein cholesterol (HDL-C) were associated with non-osteoporotic patients. Age, parathyroid hormone (PTH), total cholesterol (TC), and LDL-C were negatively linked to bone mineral density (BMD), while body mass index (BMI), uric acid (UA) level, HDL-C level, and glomerular filtration rate (eGFR) were positively related to BMD. In postmenopausal women, raised LDL-C was an independent risk factor for OP, while raised HDL-C was protective. Conclusion: Blood lipid levels are related to sex in older T2DM patients, with HDL-C being a protective factor for OP in both men and women, and LDL-C being a predictor for OP in postmenopausal women.
Review
Biochemistry & Molecular Biology
Isabella D. Cooper, Kenneth H. Brookler, Catherine A. P. Crofts
Summary: Patients with T2DM and/or CVD have lower levels of osteocalcin and bone remodelling, leading to increased risk of fragility fractures. Hyperinsulinaemia in these patients is associated with normal to increased bone mineral density and higher risk of fragility fractures. Hyperinsulinaemia leads to decreased antioxidant activity and mitochondrial dysfunction, affecting osteoblast/cytogenesis and osteocyte viability.
Article
Endocrinology & Metabolism
Tingting Ye, Liujin Lu, Liuqing Guo, Min Liang
Summary: Hemoglobin levels are associated with the presence of osteoporosis in men with type 2 diabetes, especially in those aged 50 years and older.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Guiwu Huang, Xiong Chen, Yanbo Chen, Wenzhou Liu, Chen Chen, Weidong Song, Gang Zeng
Summary: A Mendelian randomization study conducted in East Asian populations found that there is no causal relationship between type 2 diabetes mellitus and bone mineral density.
OSTEOPOROSIS INTERNATIONAL
(2023)