期刊
BIOMEDICAL OPTICS EXPRESS
卷 5, 期 9, 页码 2931-2949出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.5.002931
关键词
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资金
- National Institutes of Health [R01-EY011289-26, R44-EY022864-02, R01-CA075289-16, R44-CA101067-05, R01-CA178636-02]
- Air Force Office of Scientific Research AFOSR [FA9550-10-1-0063, FA9550-12-10499]
- Deutsche Forschungsgemeinschaft [DFG-GSC80-SAOT, DFG-HO-1791/11-1]
- DFG Training Group Heterogeneous Image Systems [1773]
Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of conventional OCT and can assess depth-resolved tissue birefringence in addition to intensity. Most existing PS-OCT systems are relatively complex and their clinical translation remains difficult. We present a simple and robust all-fiber PS-OCT system based on swept source technology and polarization depth-encoding. Polarization multiplexing was achieved using a polarization maintaining fiber. Polarization sensitive signals were detected using fiber based polarization beam splitters and polarization controllers were used to remove the polarization ambiguity. A simplified post-processing algorithm was proposed for speckle noise reduction relaxing the demand for phase stability. We demonstrated systems design for both ophthalmic and catheter-based PS-OCT. For ophthalmic imaging, we used an optical clock frequency doubling method to extend the imaging range of a commercially available short cavity light source to improve polarization depth-encoding. For catheter based imaging, we demonstrated 200 kHz PS-OCT imaging using a MEMS-tunable vertical cavity surface emitting laser (VCSEL) and a high speed micromotor imaging catheter. The system was demonstrated in human retina, finger and lip imaging, as well as ex vivo swine esophagus and cardiovascular imaging. The all-fiber PS-OCT is easier to implement and maintain compared to previous PS-OCT systems and can be more easily translated to clinical applications due to its robust design. (C) 2014 Optical Society of America
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