期刊
BIOMEDICAL OPTICS EXPRESS
卷 5, 期 3, 页码 752-762出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.5.000752
关键词
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资金
- EPSRC [EP/F020422/1, EP/1018328/1]
- EPSRC [EP/I018328/1, EP/F020422/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F020422/1, EP/I018328/1] Funding Source: researchfish
We report on a new articular cartilage imaging technique with potential for clinical arthroscopic use, by supplementing the variable-incidence- angle polarization-sensitive optical coherence tomography method previously developed by us with a conical beam scan protocol. The technique is validated on bovine tendon by comparing experimental data with simulated data generated using the extended Jones matrix calculus. A unique capability of this new optical technique is that it can locate the brushing direction of collagen fibers in articular cartilage, which is structural information that extends beyond established methods such as split-line photography or birefringent fast-axis measurement in that it is uniquely defined over the full azimuthal-angle range of (-pi, + pi). The mapping of this direction over the cartilage surface may offer insights into the optimal design of tissue-engineering scaffolds for cartilage repair. (C) 2014 Optical Society of America
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