期刊
BIOMEDICAL OPTICS EXPRESS
卷 5, 期 7, 页码 2113-2124出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.5.002113
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资金
- Australian Research Council
- National Health and Medical Research Council (Australia)
- National Breast Cancer Foundation (Australia)
- Raine Medical Research Foundation
- Cancer Council Western Australia
- Gledden Trust of The University of Western Australia
- Scholarship for International Research Fees, The University of Western Australia
- National Breast Cancer Foundation [NC-12-19] Funding Source: researchfish
We present optical coherence micro-elastography, an improved form of compression optical coherence elastography. We demonstrate the capacity of this technique to produce en face images, closely corresponding with histology, that reveal micro-scale mechanical contrast in human breast and lymph node tissues. We use phase-sensitive, three-dimensional optical coherence tomography (OCT) to probe the nanometer-to-micrometer-scale axial displacements in tissues induced by compressive loading. Optical coherence micro-elastography incorporates common-path interferometry, weighted averaging of the complex OCT signal and weighted least-squares regression. Using three-dimensional phase unwrapping, we have increased the maximum detectable strain eleven-fold over no unwrapping and the minimum detectable strain is 2.6 mu epsilon. We demonstrate the potential of mechanical over optical contrast for visualizing micro-scale tissue structures in human breast cancer pathology and lymph node morphology. (C) 2014 Optical Society of America
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