Article
Multidisciplinary Sciences
Hyun-Keun Kwon, Kyung-Do Han, Yong-Il Cheon, Sung-Chan Shin, Minhyung Lee, Eui-Suk Sung, Jin-Choon Lee, Byung-Joo Lee
Summary: This study revealed that head and neck cancer patients have increased risks of myocardial infarction, stroke, and mortality, with the highest risk of stroke in hypopharynx cancer patients and the highest risks of myocardial infarction and mortality in patients receiving chemotherapy alone.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Fu-Hsuan Liu, Jing-Yang Huang, Che Lin, Tsu-Jen Kuo
Summary: A study conducted in Taiwan on patients with head and neck cancer (HNC) found that they did not have a higher risk of all-cause mortality compared to patients with other cancers. However, the risk of suicide mortality in HNC patients was higher than that of patients without cancer and patients with other cancers.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Otorhinolaryngology
Wenli Liu, Aiham Qdaisat, Shouhao Zhou, Clifton D. Fuller, Renata Ferrarotto, Ming Guo, Stephen Y. Lai, Richard Cardoso, Abdallah S. R. Mohamed, Gabriel Lopez, Santhosshi Narayanan, Lisanne V. van Dijk, Lorenzo Cohen, Eduardo Bruera, Sai-Ching J. Yeung, Ehab Y. Hanna
Summary: In patients with squamous cell carcinoma of the oropharynx and oral cavity receiving platinum-based induction followed by concurrent chemoradiation, hypomagnesemia is predictive of osteoradionecrosis development.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Multidisciplinary Sciences
Andreas Wieland, Mihir R. Patel, Maria A. Cardenas, Christiane S. Eberhardt, William H. Hudson, Rebecca C. Obeng, Christopher C. Griffith, Xu Wang, Zhuo G. Chen, Haydn T. Kissick, Nabil F. Saba, Rafi Ahmed
Summary: Detailed analyses of B cells in the tumor microenvironment of HPV-linked head and neck cancers reveal strong humoral immune responses to HPV antigens and the secretion of HPV-specific antibodies in situ. The findings suggest that tumor-infiltrating B cells could potentially be utilized for the development of therapeutic agents in human cancer.
Article
Medicine, Research & Experimental
Ian Messing, Sharad Goyal, Jonathan H. Sherman, Punam Thakkar, Robert Siegel, Arjun Joshi, Joseph Goodman, Martin Ojong-Ntui, Yuan James Rao
Summary: Limited data is available on head and neck cancer patients presenting with brain metastases at initial diagnosis. Most patients receive radiation therapy and chemotherapy for treatment, with immunotherapy not influencing median survival.
Article
Oncology
Nathaniel S. Treister, Michael T. Brennan, Thomas P. Sollecito, Brian L. Schmidt, Lauren L. Patton, Rebecca Mitchell, Robert Haddad, Roy B. Tishler, Alexander Lin, Ryann Shadick, James S. Hodges, Rajesh Lalla
Summary: This report describes the incidence and clinical course of exposed bone in head and neck cancer patients treated with radiation therapy in the multicenter observational study OraRad. The results showed that the average maximum radiation dose to the affected area of exposed bone was 5456 cGy, with the majority of cases occurring in the mandible. The incidence of confirmed osteoradionecrosis was 3.1%, with risk factors including pre-RT extractions, higher radiation dose, and tobacco use.
Article
Oncology
Herbert Riechelmann, Daniel Dejaco, Teresa Bernadette Steinbichler, Anna Lettenbichler-Haug, Maria Anegg, Ute Ganswindt, Gabriele Gamerith, David Riedl
Summary: This study reported the functional outcomes of 681 newly diagnosed head and neck cancer (HNC) patients using the HNC-Functional InTegrity (FIT) Scales. The results showed that 61% of patients had normal or near-normal outcomes in all six functional domains, while clinically relevant impairment in at least one domain was observed in 30% of patients and loss of function in at least one domain was observed in 9% of patients. These findings suggest that clinically relevant persistent functional deficits should be expected in 40% of HNC patients. Treatment of these deficits is an important task of oncologic follow-up.
Review
Otorhinolaryngology
Yu Wang, Mingyi Wang, Lili Hou, Fuping Xiang, Xiaomei Zhao, Meizhen Qian
Summary: This study systematically reviewed the incidence and risk factors of surgical site infection (SSI) in patients with head and neck cancer. The results showed that low BMI, diabetes, high ASA score, radiotherapy, chemotherapy, clindamycin antibiotic, deficit repair, neck dissection, blood transfusion, mandibular surgery, tracheostomy, long operation time, and low ALB were significant risk factors for SSI in these patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Il Hwan Lee, Hyunjae Yu, Seung-Su Ha, Hee Gyu Yang, Dong-Kyu Kim
Summary: This study found a correlation between head and neck cancer, particularly oral cavity cancer, and the development of Alzheimer's disease (AD). Female, middle-aged patients, and those within the first year after HNC diagnosis had a higher risk of developing AD.
Review
Nutrition & Dietetics
Dinko Martinovic, Daria Tokic, Ema Puizina Mladinic, Mislav Usljebrka, Sanja Kadic, Antonella Lesin, Marino Vilovic, Slaven Lupi-Ferandin, Sasa Ercegovic, Marko Kumric, Josipa Bukic, Josko Bozic
Summary: While surgical therapy for head and neck cancer (HNC) has improved, the focus should also be on supportive pre and aftercare. Nutritional management is challenging due to complications and reduced oral intake, but enteral nutrition is preferred. However, there is a lack of studies, recommendations, and guidelines for HNC patients' nutritional management. This narrative review highlights the need for future research and an algorithm for better nutritional care.
Article
Otorhinolaryngology
Ajay T. Bakas, Harmke A. Polinder-Bos, Fleur Streng, Francesco U. S. Mattace-Raso, Gijsbertus Ziere, Rob J. Baatenburg de Jong, Aniel Sewnaik
Summary: This study found that the G8 is a valid screening tool to identify frail patients in younger patients with head and neck cancer, and it is associated with mortality.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Review
Otorhinolaryngology
Mu-Hsing Ho, Polly Wai Chi Li, Yen-Kuang Lin, Jung Jae Lee, Chia-Chin Lin
Summary: This study aimed to summarize the incidence of postoperative delirium among cancer patients undergoing head and neck surgery and determine the differential incidence rates among patients undergoing different types of head and neck surgeries. The results showed that the incidence of postoperative delirium in patients who underwent free flap reconstruction was higher than those of other types of surgeries. The sample size of the included studies was found to be a factor affecting heterogeneity.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Nutrition & Dietetics
Zalina Abu Zaid, May Kay Neoh, Zulfitri Azuan Mat Daud, Nor Baizura Md Yusop, Zuriati Ibrahim, Zuwariah Abdul Rahman, Norshariza Jamhuri, Aishah Zafirah Abdul Azim
Summary: This study aimed to evaluate the weight loss during and post-treatment among head and neck cancer patients. The study found that the average weight loss during treatment was 7.4%, and post-treatment weight loss was 2.1%. One month after treatment completion, patients showed significant improvements in nutrition status and muscle mass, but there was a decrease in oral nutritional supplement intake.
Article
Dentistry, Oral Surgery & Medicine
Jorine A. Vermaire, Cornelis P. J. Raaijmakers, Evelyn M. Monninkhof, Irma M. Verdonck-de Leeuw, Chris H. J. Terhaard, Caroline M. Speksnijder
Summary: This prospective cohort study investigated the relationship between swallowing function and personal and clinical factors in patients with head and neck cancer. The results showed that the worst swallowing function occurred 3 months after treatment, and older age and surgery were associated with swallowing dysfunction over time.