Article
Neurosciences
Qinqing Li, Hongfeng Dai, Fengming Ran, Yueyuan Luo, Jingyan Gao, Ailin Deng, Nan Xu, Chengde Liao, Jun Yang
Summary: The study aimed to evaluate the impact of radiation-induced brain injury (RIBI) on axonal transport (AT) and sexual function. The findings suggested that RIBI could impair foraging ability and sexual function in rats. MRI examination revealed AT impairment in the olfactory pathway of the irradiated rats. The deficits in AT were attributed to declines in motor protein levels, neuronal apoptosis, synaptic damage, and energy metabolism dysfunction. Moreover, the sexual dysfunction induced by cranial irradiation was associated with reduced sex hormone levels.
Article
Biology
Mengjing Bao, Ruth E. Doerig, Paula Maria Vazquez-Pianzola, Dirk Beuchle, Beat Suter
Summary: In this study, the glutamylation of a-tubulin isotypes in Drosophila ovaries was investigated. It was found that the C-terminal ends of alpha Tub84B/D were glutamylated, while alpha Tub67C was not. TTLL5 was identified as the protein responsible for mono- and poly-glutamylation of alpha Tub84B/D and its proper localization. This study also demonstrated the dependence of kinesin-1 distribution, as well as other cellular functions such as axonal transport and ooplasmic streaming, on TTLL5 and alpha-tubulin glutamylation.
Editorial Material
Biochemistry & Molecular Biology
Pedro Brites, Monica M. Sousa
Summary: In a mouse model, Kreher and colleagues demonstrate that neurons, not only myelinating glia, are the primary contributors to disease progression in Krabbe disease. The neuron-specific model they generated allows for investigation of the autonomous neuronal component of this disorder.
Article
Neurosciences
David K. Sidibe, Maria C. Vogel, Sandra Maday
Summary: This review discusses the organization of the autophagy pathway in neurons and its compartment-specific mechanisms and functions in different cellular regions. Furthermore, it highlights the critical importance of autophagy in maintaining neuronal function and survival, and explores the impairment of the autophagy pathway in aging and neurodegenerative diseases.
CURRENT OPINION IN NEUROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Reem Abouward, Giampietro Schiavo
Summary: Localisation of mRNA plays a crucial role in establishing and maintaining cellular polarity, synaptic plasticity, and other biological processes. Recent discoveries regarding RNA hitchhiking on cytoplasmic organelles have significant implications on our understanding of neuronal function in development, adulthood, and neurodegeneration. The mechanisms controlling mRNA localisation are largely conserved across evolution and have been extensively studied in various biological models.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Geriatrics & Gerontology
Xiaoman Yang, Jialing Wang, Weiqi Zeng, Xiaoqian Zhang, Xiaomei Yang, Yu Xu, Yan Xu, Xuebing Cao
Summary: This study introduces a novel rat model of Parkinson's disease characterized by widespread, seed-initiated endogenous alpha-Syn pathology, impaired axonal transport, and a neurodegenerative cascade in the nigrostriatal system. This model provides an important platform for further research on specific pathogenic mechanisms and pre-clinical evaluations of novel therapeutic strategies.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Gholamreza Fazeli, Roni Levin-Konigsberg, Michael C. Bassik, Christian Stigloher, Ann M. Wehman
Summary: By studying the phagocytic clearance process, researchers identified the molecular pathway that regulates the formation of small vesicles in phagolysosomes, which facilitates the efficient resolution of cell debris and pathogens. Observing single phagolysosomes over time helped to understand the mechanism behind this process.
Article
Cell Biology
Evgeniya Trofimenko, Yuta Homma, Mitsunori Fukuda, Christian Widmann
Summary: Endocytosis and endosome dynamics are regulated by small GTPase Rab proteins. Besides the known endocytic pathways, a Rab14-dependent pathway has been identified that moves material to nonacidic late endosomes. This pathway is distinct from conventional Rab5-dependent endocytosis and is not affected by inhibitors of macropinocytosis or clathrin-mediated endocytosis.
Article
Environmental Sciences
Xuhong Zhang, Xiaoyu Wang, Hong Zhu, Dongyan Zhang, Jinbo Chen, Yingying Wen, Yanqing Li, Le Jin, Chen Xie, Dongyu Guo, Ting Luo, Jianping Tong, Yudong Zhou, Ye Shen
Summary: Artificial light is crucial for modern life, but it can have negative effects on health. Exposure to short wavelength artificial light during early development in mice delays the development of the visual pathway and impairs neuronal structure and neurotransmitter function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biology
Georgina Kontou, Pantelis Antonoudiou, Marina Podpolny, Blanka R. Szulc, I. Lorena Arancibia-Carcamo, Nathalie F. Higgs, Guillermo Lopez-Domenech, Patricia C. Salinas, Edward O. Mann, Josef T. Kittler
Summary: The study explores the role of Miro1 in PV+ interneurons and how changes in mitochondrial trafficking could alter network activity in the mouse brain. Impairments in Miro1-directed trafficking in PV+ interneurons altered their mitochondrial distribution and axonal arborization, while PV+ interneuron-mediated inhibition remained intact. These changes were accompanied by an increase in hippocampal gamma-oscillation frequency and promoted anxiolysis. Our findings show that precise regulation of mitochondrial dynamics in PV+ interneurons is crucial for proper neuronal signaling and network synchronization.
Review
Biochemistry & Molecular Biology
Mariana Santana Dias, Xiaoyue Luo, Vinicius Toledo Ribas, Hilda Petrs-Silva, Jan Christoph Koch
Summary: Glaucoma is a neurodegenerative disease that leads to progressive vision loss by affecting the retinal ganglion cells (RGCs). Impairment of axonal transport at the optic nerve head (ONH) is an important feature of glaucoma, and is believed to occur early in the disease before axonal and somal degeneration. Understanding the role of axonal transport in glaucoma is crucial for deciphering disease mechanisms and developing early therapies to prevent irreversible neuronal damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Ana Catarina Costa, Monica Mendes Sousa
Summary: Neurons are polarized cells and the regulation of the microtubule cytoskeleton is crucial for their function. A group of microtubule-severing enzymes, including spastin, have been found to play an important role in regulating microtubule organization and axonal transport.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Kyle R. Christensen, Benjamin Combs, Collin Richards, Tessa Grabinski, Mohammed M. Alhadidy, Nicholas M. Kanaan
Summary: Our understanding of the tau protein's role as a scaffolding protein involved in signaling regulation has implications for Alzheimer's disease and other tauopathies. Pseudophosphorylation of tau disrupts normal axonal transport through a PP1-dependent pathway. Interaction between tau and PP1 gamma, as well as tau phosphorylation at S199-T205, leads to axonal transport impairment.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lihong Liang, Hai Lin, Fan Lin, Jihu Yang, Hanwen Zhang, Liang Zeng, Yaqiong Hu, Weiwu Lan, Hua Zhong, Hong Zhang, Siping Luo, Yongqian Mo, Weihua Li, Yi Lei
Summary: This study demonstrates the clinical applicability of DSI for quantitative detection of visual pathway abnormalities and prediction of visual field defects in patients with pituitary adenomas. The DSI parameters are significantly correlated with chiasmal lift distance and the degree of visual defects, and the classifiers can effectively discriminate between patients with mild and severe visual defects.
EUROPEAN RADIOLOGY
(2021)
Article
Cell Biology
Heather Tsong, Erika L. F. Holzbaur, Andrea K. H. Stavoe
Summary: Misregulation of neuronal autophagy is involved in age-related neurodegenerative diseases. Aging leads to a decrease in autophagosome formation rate and density along the axon, but an increase in autophagic vesicle maturation. Late aging results in a significant loss of acidified vesicles in the distal axon, while the efficient transport of autophagic vesicles in both proximal and distal axons is maintained during early aging. These findings suggest that aging differentially impacts distinct aspects of neuronal autophagy.
Editorial Material
Genetics & Heredity
Samaneh Farashi, Zhichao Wu, Carla J. Abbott, Alice Pebay, Erica L. Fletcher, Robyn H. Guymer, Melanie Bahlo, Brendan R. E. Ansell
Summary: Reticular pseudodrusen (RPD) is a distinct phenotype associated with late-stage age-related macular degeneration (AMD), characterized by subretinal deposits. The genetic risk associations of RPD overlap with six established AMD-risk regions. Identifying the specific underlying genetic causes of RPD through adequate imaging methods can enhance our understanding of RPD pathophysiology.
TRENDS IN GENETICS
(2022)
Article
Ophthalmology
Samuel A. Titchener, David A. X. Nayagam, Jessica Kvansakul, Maria Kolic, Elizabeth K. Baglin, Carla J. Abbott, Myra B. McGuinness, Lauren N. Ayton, Chi D. Luu, Steven Greenstein, William G. Kentler, Mohit N. Shivdasani, Penelope J. Allen, Matthew A. Petoe
Summary: This study reports the long-term observations of the electrode-tissue interface and perceptual stability in humans after chronic stimulation with a 44-channel suprachoroidal retinal implant. The results showed stable electrode impedances, small individual changes in perceptual electrical thresholds, and no clinically significant increase in electrode-retina distances after a period of settling after surgery.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Ophthalmology
Kai Lyn Goh, Himeesh Kumar, Xavier Hadoux, Maxime Jannaud, Carla Abbott, Lauren Hodgson, Luba Robman, Galina Makeyeva, Peter Van Wijngaarden, Robyn Guymer, Zhichao Wu
Summary: This study aimed to investigate the additional prognostic value of quantifying the extent of hyperpigmentary abnormalities (HPAs) defined by color fundus photography (CFP) and their association with visual sensitivity in individuals with intermediate age-related macular degeneration (AMD). The results showed that quantifying the extent of HPAs did not improve the prediction of late AMD development compared to the presence alone, and the extent of HPAs was associated with localized reductions in visual sensitivity. Overall, these findings suggest that quantifying the extent of HPAs provides little additional information for predicting AMD progression but serves as an imaging biomarker for visual dysfunction.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Editorial Material
Ophthalmology
Myra B. McGuinness, Carla J. Abbott
JAMA OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Nick Grissom, Stuart K. Gardiner, Jack P. Rees, Facundo G. Sanchez, Steven L. Mansberger, Emmett T. Cunningham Jr, Claude F. Burgoyne, Karen Rice, Christina Belter, Robert M. Kinast
Summary: This study evaluated eye drop self-administration in low-vision patients and found that a nose-pivoted drop delivery device (NPDD) can improve eye drop delivery. The use of NPDD increased the success rate of eye drop delivery and reduced bottle tip contact. Patients reported higher satisfaction and increased confidence in independently using eye drops with NPDD.
OPHTHALMOLOGY GLAUCOMA
(2023)
Article
Ophthalmology
Claude f. Burgoyne, Ya xing Wang, Jin wook Jeoung, S. E. U. N. G. W. O. O. Hong, S. T. U. A. R. T. Gardiner, J. U. A. N. Reynaud, B. R. A. D. Fortune, Michael j. a. Girard, G. L. E. N. Sharpe, M. A. R. C. E. L. O. Nicolela, Balwantray c. Chauhan, H. O. N. G. L. Yang
Summary: This study used OCT to compare highly myopic and normal eyes and found that pNC-SB increased and pNC-CT decreased in highly myopic eyes, with the greatest changes in the inferior sectors. The results support the hypothesis that sectors of maximum pNC-SB may predict areas of greatest susceptibility to aging and glaucoma in future longitudinal studies of highly myopic eyes.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Leslie Guadron, Samuel A. Titchener, Carla J. Abbott, Lauren N. Ayton, John van Opstal, Matthew A. Petoe, Jeroen Goossens
Summary: This study investigated the effects of central and peripheral retinal defects on horizontal eye movements and found that these defects altered the kinematics of saccades, especially when the target was in the blind field. This suggests that visual inputs play a crucial role in planning the kinematics of saccades.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Letter
Ophthalmology
Kai Lyn Goh, Fred K. Chen, Chandrakumar Balaratnasingam, Carla J. Abbott, Lauren A. B. Hodgson, Robyn H. Guymer, Zhichao Wu
Letter
Ophthalmology
Kai Lyn Goh, Fred K. Chen, Chandrakumar Balaratnasingam, Carla J. Abbott, Lauren A. B. Hodgson, Robyn H. Guymer, Zhichao Wu
Meeting Abstract
Ophthalmology
Lisa Lombardi, Maria Kolic, Elizabeth Baglin, Matthew Petoe, Carla Abbott, Lauren Moussallem, Sam Stefopoulos, Xerxes Battiwalla, Janine Walker, Nick Barnes, Penelope Allen
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Meeting Abstract
Ophthalmology
Lauren Moussallem, Maria Kolic, Elizabeth Baglin, Matthew Petoe, Carla Abbott, Lisa Lombardi, Sam Stefopoulos, Xerxes Battiwalla, Janine Walker, Nick Barnes, Penelope Allen
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Meeting Abstract
Ophthalmology
Penelope J. Allen, Carla J. Abbott, Maria Kolic, Elizabeth Baglin, David A. X. Nayagam, Stephanie Epp, Nicholas Barnes, Chi D. Luu, Robert Briggs, Jonathan Yeoh, William Kentler, Samuel Titchener, Christopher E. Williams, Matthew Petoe
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Kai Lyn Goh, Carla J. Abbott, Xavier Hadoux, Maxime Jannaud, Lauren A. B. Hodgson, Peter van Wijngaarden, Robyn H. Guymer, Zhichao Wu
Summary: In a cohort with bilateral large drusen, the presence and extent of HCD were not independently associated with an increased rate of progression to late AMD, nor with lower visual sensitivity or an increased rate of visual sensitivity decline before the development of late AMD, after adjusting for known risk factors for disease progression.
OPHTHALMOLOGY RETINA
(2022)
Meeting Abstract
Ophthalmology
Carla J. Abbott, Samuel A. Titchener, Maria Kolic, Elizabeth K. Baglin, Jessica Kvansakul, William G. Kentler, Nick Barnes, David A. X. Nayagam, Lauren N. Ayton, Chi D. Luu, Penelope J. Allen, Matthew A. Petoe
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Meeting Abstract
Ophthalmology
Penelope J. Allen, David A. X. Nayagam, Stephanie Epp, Chi D. Luu, Nick Barnes, Maria Kolic, Elizabeth K. Baglin, Carla J. Abbott, Robert J. Briggs, Jonathan Yeoh, William G. Kentler, Jessica Kvansakul, Samuel A. Titchener, Matthew A. Petoe, Christopher E. Williams
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
