期刊
BIOMEDICAL OPTICS EXPRESS
卷 4, 期 7, 页码 1119-1132出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.4.001119
关键词
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资金
- National Institutes of Health [R01-CA75289-16, R44-CA101067-06, R44EY022864-01, R01-EY011289-27, R01-HL095717-04, R01-NS057476-05]
- Air Force Office of Scientific Research [FA9550-10-1-0063]
- Medical Free Electron Laser Program [FA9550-10-1-0551]
- German Research Foundation [DFG-GSC80-SAOT, DFG-HO-1791/11-1]
We developed a micromotor based miniature catheter with an outer diameter of 3.2 mm for ultrahigh speed endoscopic swept source optical coherence tomography (OCT) using a vertical cavity surface-emitting laser (VCSEL) at a 1 MHz axial scan rate. The micromotor can rotate a micro-prism at several hundred frames per second with less than 5 V drive voltage to provide fast and stable scanning, which is not sensitive to the bending of the catheter. The side-viewing probe can be pulled back to acquire a three-dimensional (3D) data set covering a large area on the specimen. The VCSEL provides a high axial scan rate to support dense sampling under high frame rate operation. Using a high speed data acquisition system, in vivo 3D-OCT imaging in the rabbit GI tract and ex vivo imaging of a human colon specimen with 8 mu m axial resolution, 8 mu m lateral resolution and 1.2 mm depth range in tissue at a frame rate of 400 fps was demonstrated. (C) 2013 Optical Society of America
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