期刊
BIOMEDICAL OPTICS EXPRESS
卷 3, 期 3, 页码 378-387出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.3.000378
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资金
- EPSRC [EP/F020422]
- EPSRC [EP/F020422/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F020422/1] Funding Source: researchfish
We report results to verify a theoretical framework to analyze the 3D depth-wise structural organization of collagen fibers in articular cartilage using polarization-sensitive optical coherence tomography. Apparent birefringence data obtained from multi-angle measurements using a time domain polarization-sensitive optical coherence tomography system has been compared with simulated data based on the extended Jones matrix calculus. Experimental data has been shown to agree with the lamellar model previously proposed for the cartilage microstructure based on scanning electron microscopy data. This tool could have potential application in mapping the collagen structural orientation information of cartilage non-invasively during arthroscopy. (c) 2012 Optical Society of America
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