期刊
BIOMEDICAL OPTICS EXPRESS
卷 3, 期 5, 页码 1077-1085出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.3.001077
关键词
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资金
- National Institutes of Health/National Cancer Institute [R01-CA133148]
- National Institutes of Health/National Institute of Biomedical Imaging and Bioengineering [R01-EB006736]
We characterize long (up to 285 mm) gradient index (GRIN) lens endoscope systems for multiphoton imaging. We fabricate a portable, rigid endoscope system suitable for imaging unstained tissues, potentially deep within the body, using a GRIN lens system of 1 mm diameter and 8 cm length. The portable device is capable of imaging a similar to 200 mu m diameter field of view at 4 frames/s. The lateral and axial resolution in water is 0.85 mu m and 7.4 mu m respectively. In vivo images of unstained tissues in live, anesthetized rats using the portable device are presented. These results show great promise for GRIN endoscopy to be used clinically. (c) 2012 Optical Society of America
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