期刊
BIOMEDICAL OPTICS EXPRESS
卷 2, 期 5, 页码 1059-1068出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.2.001059
关键词
-
资金
- National Heart, Lung, and Blood Institute [R01 HL093140]
- National Institute of Biomedical Imaging and Bioengineering [R01 EB009682]
- American Heart Association [0855733G]
Studying renal microcirculation and its dynamics is of great importance for understanding the renal function and further aiding the diagnosis, prevention and treatment of renal pathologies. In this paper, we present a potentially useful method to provide high-sensitive volumetric imaging of renal microcirculations using ultrahigh-sensitive optical microangiography (UHS-OMAG). The UHS-OMAG image system used here is based on spectral domain optical coherence tomography, which uses a broadband light source centered at 1300 nm with an imaging speed of 150 frames per second that requires similar to 6.7 sec to complete one 3D scan of similar to 2.5 x 2.5 mm(2) area. The technique is sensitive enough to image capillary networks, such as peritubular capillaries within renal cortex. We show the ability of UHS-OMAG to provide depth-resolved volumetric images of capillary level renal microcirculation. We also show that UHS-OMAG is capable of monitoring the changes of renal microcirculation in response to renal ischemia and reperfusion. Finally, we attempt to show the capability of OMAG to provide quantitative analysis about velocity changes in a single capillary vessel (down to tens of microns per second) in response to the ischemic event. (C) 2011 Optical Society of America
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据