期刊
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
卷 5, 期 -, 页码 249-257出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjnano.5.27
关键词
bioconjugation; biodistribution; gadolinium oxide; humicola sp; transmission electron microscopy
资金
- Council of Scientific and Industrial Research (CSIR), New Delhi for a Senior Research Fellowship
- Department of Biotechnology, Govt. of India (New Delhi) for the Tata Innovation Fellowship award
- CSIR, New Delhi [BSC0112]
As a part of our programme to develop nanobioconjugates for the treatment of cancer, we first synthesized extracellular, protein-capped, highly stable and well-dispersed gadolinium oxide (Gd2O3) nanoparticles by using thermophilic fungus Humicola sp. The biodistribution of the nanoparticles in rats was checked by radiolabelling with Tc-99m. Finally, these nanoparticles were bioconjugated with the chemically modified anticancer drug taxol with the aim of characterizing the role of this bioconjugate in the treatment of cancer. The biosynthesized Gd2O3 nanoparticles were characterized by UV-vis spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoemission spectroscopy (XPS). The Gd2O3-taxol bioconjugate was confirmed by UV-vis spectroscopy and fluorescence microscopy and was purified by using high performance liquid chromatography (HPLC).
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