Review
Dermatology
Guoqi Wang, Haiyan Xu, Gaoxiang Xu, Hao Zhang, Zhirui Li, Daohong Liu
Summary: Comparing negative pressure wound therapy with instillation (NPWTi) and standard negative pressure wound therapy, this study found that NPWTi resulted in fewer surgeries and dressing changes, and smaller wound areas post-treatment compared to NPWT. However, no significant differences were observed in other clinical outcomes between NPWTi and NPWT. Further well-designed RCTs with larger sample sizes are needed to validate these conclusions due to heterogeneity.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Pediatrics
Milan Slavkovic, Dragoljub Zivanovic, Sinisa Ducic, Valentina Lasic, Nado Bukvic, Harry Nikolic, Vlatka Martinovic
Summary: Treating complicated wounds in pediatric patients can be challenging due to the need for frequent dressing changes and patient distress. Topical negative pressure wound therapy offers localized benefits and accelerates wound healing. This study compares the results of NPWT with traditional wet to moist dressing on pediatric patients and recommends NPWT as a safe and effective method for downgrading wounds and improving scar appearance.
Article
Emergency Medicine
Shizhao Ji, Xiaobin Liu, Jie Huang, Junmin Bao, Zhaohong Chen, Chunmao Han, Daifeng Hao, Jingsong Hong, Dahai Hu, Yufeng Jiang, Shang Ju, Hongye Li, Zongyu Li, Guangping Liang, Yan Liu, Gaoxing Luo, Guozhong Lv, Xingwu Ran, Zhongmin Shi, Juyu Tang, Aiping Wang, Guangyi Wang, Jiangning Wang, Xin Wang, Bing Wen, Jun Wu, Hailin Xu, Maojin Xu, Xiaofei Ye, Liangxi Yuan, Yi Zhang, Shichu Xiao, Zhaofan Xia
Summary: As China becomes an aging society, the incidence of diabetes and diabetic foot is increasing, making it a major health concern. Negative pressure wound therapy (NPWT) has shown great progress in the treatment of diabetic foot wounds, but irregular application can lead to complications. The consensus aims to provide clinicians with standardized treatment schemes for diabetic foot cases based on evidence-based practice.
Article
Surgery
Griffin Boll, Peter Callas, Daniel J. Bertges
Summary: This meta-analysis aimed to evaluate the efficacy of closed incision negative pressure wound therapy (ciNPWT) on vascular surgery groin wounds. The results showed that ciNPWT was associated with a significant reduction in surgical site infections (SSIs). However, no significant differences were found in other secondary outcomes.
JOURNAL OF VASCULAR SURGERY
(2022)
Review
Pharmacology & Pharmacy
Eun Jo Jang, Rajkumar Patel, Madhumita Patel
Summary: Globally, diabetic mellitus (DM) is a common metabolic disease that inhibits insulin production, destroys pancreatic beta cells, and promotes hyperglycemia. This disease causes complications such as slow wound healing, increased risk of infection, and development of chronic wounds, which can be fatal. The current methods of wound healing are insufficient for diabetic patients due to a lack of antibacterial ability and sustained delivery of necessary factors. To address this, a new method of creating wound dressings using electrospinning has been developed, which mimics the extracellular matrix and effectively stores and delivers active substances for diabetic wound healing. This review discusses different polymers used in creating nanofiber membranes and their effectiveness in treating diabetic wounds.
Article
Biochemistry & Molecular Biology
Kelly McElvain, Joshua Klister, Alessandra Ebben, Sandeep Gopalakrishnan, Mahsa Dabagh
Summary: Chronic wounds have a significant impact on individuals' health-related quality of life and healthcare systems worldwide. This study investigates the influence of mechanotransduction on the healing process in chronic wounds through the development of three-dimensional tissue models. The results demonstrate that wound dressings with lower stiffness promote force transmission within the wound tissue, with larger dressings exerting higher stresses. These findings highlight the importance of dressing characteristics in promoting healing and provide insights for the design of precision dressings.
Article
Dermatology
Yen-Jen Wang, Xiao-Feng Yao, Yang-Sheng Lin, Jen-Yu Wang, Chang-Cheng Chang
Summary: Negative pressure wound therapy (NPWT) shows no significant difference in tumor recurrence rates compared with conventional non-pressure dressings for cancer surgical wounds without residual tumor, but it may reduce the risk of postoperative complications. NPWT can be considered an alternative method for reconstruction in challenging cases.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Surgery
Jose Bueno-Lledo, Ascension Franco-Bernal, Maria Teresa Garcia-Voz-Mediano, Antonio Torregrosa-Gallud, Santiago Bonafe
Summary: This study found that the use of prophylactic sNPWT PICO dressing for closed surgical incisions following IH repair significantly reduces the overall incidence of SSOs and wound infections at 30 days postoperatively, showing promising efficacy in preventing SSos.
Article
Dermatology
Ahmed H. Elhessy, Arif R. Chaudhry, Ahmed Hammouda, Shawn D. Giacobbe, Martin G. Gesheff, Janet D. Conway
Summary: This study presents a descriptive analysis of the application of NPWTi in management of complex infected orthopaedic lower limb wounds, showing promising outcomes for wound closure and improved healing process. Randomised controlled studies are needed to further evaluate the effectiveness of NPWTi compared to conventional treatment methods.
INTERNATIONAL WOUND JOURNAL
(2021)
Review
Dermatology
Lijiao Wu, Baoyu Wen, Zhaorong Xu, Kefeng Lin
Summary: This paper reviews the research progress of parameters for negative pressure wound therapy with instillation (NPWTi) and their application in the treatment of orthopaedic wounds, highlighting the lack of unified parameters at present.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Yunshu Yang, Mengdong Liu, Fangfang Yang, Xujie Wang, Xiaozhi Bai, Shengzhi Mu, Yang Liu, Dahai Hu
Summary: Infections of burn wounds, especially those caused by Pseudomonas aeruginosa, can lead to sepsis or septic shock, which are major causes of death after burn injury. Negative pressure wound therapy (NPWT) is more effective than traditional methods in preventing and treating wound infections. This study explored the molecular mechanisms of NPWT in a mouse model of P. aeruginosa-infected burn wounds and found that NPWT can reduce P. aeruginosa levels, improve blood flow, promote wound healing, and alleviate wound inflammation.
Article
Engineering, Biomedical
Rimei Chen, Chao Zhao, Zhiping Chen, Xiaoyu Shi, Hongxiang Zhu, Qing Bu, Lei Wang, Chunfang Wang, Hui He
Summary: The study developed a near infrared and pH-responsive bionic nanocage wound dressing that can provide dual photothermal therapy for tumor and infection-induced wound healing. It has high drug-loading capacity, controllable drug release, and excellent antibacterial properties.
Article
Dermatology
Yanjun Liu, Mingze Xu, Zheng Wang, Xiaoshu Zhu, Jianguo Xu
Summary: This study investigated the effects of early incisional negative pressure wound therapy (INPWT) on cosmetic suture wounds and postoperative scar hyperplasia. A total of 120 patients who underwent abdominoperineal resection were retrospectively evaluated and divided into an INPWT group and a control group. The INPWT group showed better wound healing, a higher proportion of patients with non-surgical site infection, and significantly improved scar assessment scores compared to the control group. The findings suggest that INPWT can improve the quality of cosmetic suture wounds and reduce postoperative scar hyperplasia.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Dermatology
Indri Lakhsmi Putri, Lavonia Berlina Adzalika, Rachmaniar Pramanasari, Citrawati Dyah Kencono Wungu
Summary: This study reviewed the risks and benefits of negative pressure wound therapy (NPWT) in cancer surgical wounds. The results showed that NPWT can significantly reduce the risk of surgical site infection and seroma, and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Engineering, Biomedical
Bahram Mirani, Zhina Hadisi, Erik Pagan, Seyed Mohammad Hossein Dabiri, Antonia van Rijt, Lama Almutairi, Iman Noshadi, David G. Armstrong, Mohsen Akbari
Summary: Managing slow-healing wounds and associated complications is challenging. Systematic collection, analysis, and dissemination of correct wound status data are critical for enhancing healing outcomes and reducing complications.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Alfredo Garcia-Venzor, Edna Ayerim Mandujano-Tinoco, Floria Lizarraga, Cecilia Zampedri, Edgar Krotzsch, Rosa Maria Salgado, Victor Manuel Davila-Borja, Sergio Encarnacion-Guevara, Jorge Melendez-Zajgla, Vilma Maldonado
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2019)
Review
Cell Biology
Rene Fernando Abarca-Buis, Edna Ayerim Mandujano-Tinoco, Alejandro Cabrera-Wrooman, Edgar Krotzsch
Summary: The role of TGFβ/activin signaling in wound repair and regeneration is highly conserved in the animal kingdom. This signaling can either promote or inhibit different aspects of the regeneration process, with the cellular responses depending on the activation of specific signaling pathways.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Mario Chopin-Doroteo, Edna Ayerim Mandujano-Tinoco, Edgar Krotzsch
Summary: The design of bioink must consider viscoelastic properties, rheological properties, injection speed, and printing nozzle diameter, as these are related to cell behavior and survival rate during and after printing. Mechanosensing plays a strong role in influencing epigenetics to modify final cell phenotype, which can impact replacement tissue. Biotechnologists in tissue engineering must take into account the biophysical properties and biological conditions of materials used, as well as material delivery and maturation modes, to ensure appropriate materials mimicking native tissue development.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Biotechnology & Applied Microbiology
Maria Paulette Castro-Gil, Julia Esperanza Torres-Mena, Rosa M. Salgado, Said A. Munoz-Montero, Jose Michael Martinez-Garces, Carlos David Lopez-Torres, Alfredo Mendoza-Vargas, Nayeli Belem Gabino-Lopez, Saul Villa-Trevino, Luis del Pozo-Yauner, Jaime Arellanes-Robledo, Edgar Krotzsch, Julio Isael Perez-Carreon
Summary: Our study identified a unique gene expression profile in GGT/KRT19-positive HCC through a hepatocarcinogenesis model and RNA sequencing analysis, indicating dysregulation of genes involved in fatty acid metabolism, RXR function, and hepatic stellate cell activation. Downregulation of Slc27a5, Acsl1, Rxr alpha, and Cyp2e1 genes was found to be an early event in GGT/KRT19-positive HCC, compromising the function of Retinoid X Receptor alpha and leading to NRF2 pathway activation.
Article
Critical Care Medicine
Edna Ayerim Mandujano-Tinoco, Francisco Gonzalez-Garcia, Rosa M. Salgado, Rene Fernando Abarca-Buis, Jose Manuel Sanchez-Lopez, Pilar Hazel Carranza-Castro, Luis Padilla, Edgar Krotzsch
Summary: In this study, the expression of miR-31, miR-155, and miR-221 in a murine skin transplantation model was analyzed, and it was found that the overexpression of miR-31 and miR-221, both locally and systemically, is associated with graft tolerance.
JOURNAL OF BURN CARE & RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Ernesto Tinajero-Diaz, Daniela Salado-Leza, Carmen Gonzalez, Moises Martinez Velazquez, Zaira Lopez, Jorge Bravo-Madrigal, Peter Knauth, Flor Y. Flores-Hernandez, Sara Elisa Herrera-Rodriguez, Rosa E. Navarro, Alejandro Cabrera-Wrooman, Edgar Kroetzsch, Zaira Y. Garcia Carvajal, Rodolfo Hernandez-Gutierrez
Summary: Metal-based nanoparticles are widely utilized for delivering bioactive molecules and drugs to enhance cancer therapy. The application of green chemistry in synthesizing gold and silver nanoparticles helps in reducing solvent usage and controlling their properties. Evaluation of the anticancer effects of these nanoparticles mainly involves conventional 2D cell culture and in vivo murine models.
Article
Microbiology
Alejandro Cabrera-Wrooman, Silvestre Ortega-Pena, Rosa M. Salgado, Belinda Sandoval-Cuevas, Edgar Krotzsch
Summary: A controlled-flow electrolyzed acid solution (CFEAS) was found to have excellent antiseptic and antibiofilm properties. In vitro experiments showed that CFEAS can kill both Gram-negative and Gram-positive bacteria and inhibit biofilm formation for 24 hours. Cytotoxicity tests demonstrated that CFEAS has minimal toxic effects on macrophages and good tolerance in fibroblasts. Clinical trials showed that a 24-hour CFEAS treatment significantly reduced bacterial colonization and removed biofilms from wounds.
Article
Plant Sciences
Christian Veronica Perez-Contreras, Jesus Alvarado-Flores, Alejandra Orona-Ortiz, Jose Luis Balderas-Lopez, Rosa Maria Salgado, Noe Zacaula-Juarez, Edgar Krotzsch, Andres Navarrete
Summary: The study showed that the hydroalcoholic extract of Amphipterygium adstringens and its metabolites, specifically 3 alpha-hydroxymasticadienoic acid and anacardic acids, have a positive effect on wound healing, tissue structure improvement, reduced closure time, proangiogenic effects, and modest antimicrobial effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Anatomy & Morphology
Rene Fernando Abarca-Buis, Edgar Kroetzsch
Summary: Ear pinna in mammals shows different repair responses depending on age, with limited regeneration in middle-aged mice and scar tissue formation in young mice. This study examined the effect of ear topography, age, and sex on the repairing response of ear holes in mice. The results revealed that injuries closer to the base of the ear were repaired more efficiently through limited regeneration, and ear growth also accelerated hole closure, especially in male mice.
JOURNAL OF ANATOMY
(2023)
Article
Microbiology
Silvestre Ortega-Pena, Mario Chopin-Doroteo, Alberto Tejeda-Fernandez de Lara, David M. Giraldo-Gomez, Rosa M. Salgado, Edgar Krotzsch
Summary: This study evaluated the direct and indirect effects of DACC-coated dressings on Staphylococcus aureus adhesion and growth, as well as on fibroblast and macrophage activity. The results suggest that the dressing can reduce the quantity of S. aureus in biofilm formation and does not overstimulate cell activity.
Article
Dermatology
Mario Chopin-Doroteo, Edgar Krotzsch
Summary: This study aimed to evaluate hand hygiene habits during the COVID-19 pandemic and the effect of repetitive use of soap or alcohol-based products on skin characteristics. The survey results showed that frequent hand cleansing led to skin damage. An experiment on skin moisture and elasticity among 19 healthcare workers and students supported this finding. Alcohol-based products did not significantly affect skin moisture or elasticity.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Developmental Biology
Rene Fernando Abarca-Buis, Maria Elena Contreras-Figueroa, David Garciadiego-Cazares, Edgar Krotzsch
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2020)