Article
Critical Care Medicine
Nina A. Thomas, Ralph Ward, Nichole T. Tanner, Alana M. Rojewski, Benjamin Toll, Mulugeta Gebregziabher, Gerard A. Silvestri
Summary: In a secondary analysis of the NLST arm of the American College of Radiology Imaging Network, it was found that only a quarter of lung cancer screening patients received pharmacologic therapy for smoking cessation, and those who did receive treatment were more likely to attempt to quit. Patients with high nicotine dependence benefited most from dual pharmacologic therapy.
Article
Respiratory System
Rachel Kohn, Anil Vachani, Dylan Small, Alisa J. Stephens-Shields, Dorothy Sheu, Vanessa L. Madden, Brian A. Bayes, Marzana Chowdhury, Sadie Friday, Jannie Kim, Michael K. Gould, Mohamed H. Ismail, Beth Creekmur, Matthew A. Facktor, Charlotte Collins, Kristina K. Blessing, Christine M. Neslund-Dudas, Michael J. Simoff, Elizabeth R. Alleman, Leonard H. Epstein, Michael A. Horst, Michael E. Scott, Kevin G. Volpp, Scott D. Halpern, Joanna L. Hart
Summary: This study aims to compare the effectiveness of four smoking cessation interventions among underserved patients referred for lung cancer screening. The findings will provide evidence for implementing more effective cessation strategies in lung cancer screening programs to reduce smoking burdens affecting underserved populations.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Review
Oncology
Emma L. O'Dowd, Richard W. Lee, Ahsan R. Akram, Emily C. Bartlett, Stephen H. Bradley, Kate Brain, Matthew E. J. Callister, Yan Chen, Anand Devaraj, Sinan R. Eccles, John K. Field, Jesme Fox, Seamus Grundy, Sam M. Janes, Martin Ledson, Melanie MacKean, Anne Mackie, Kieran G. McManus, Rachael L. Murray, Arjun Nair, Samantha L. Quaife, Robert Rintoul, Anne Stevenson, Yvonne Summers, Louise S. Wilkinson, Richard Booton, David R. Baldwint, Philip Crosbie
Summary: Lung cancer screening with low-dose CT has been recommended by the UK National Screening Committee based on trials showing a reduction in lung cancer mortality. The UK has made significant progress in addressing logistical issues and implementing targeted lung cancer screening through clinical trials and the NHS England Targeted Lung Health Check Programme. This Policy Review provides a summary of the consensus and key requirements for effective implementation of a screening programme, and can serve as a valuable resource for countries planning their own lung cancer screenings.
Article
Critical Care Medicine
Kristie L. Foley, Emily V. Dressler, Kathryn E. Weaver, Erin L. Sutfin, David P. Miller Jr, Christina Bellinger, Carol Kittel, Rebecca J. Stone, W. Jeffrey Petty, Stephanie R. Land, John G. Spangler, Glenn J. Lesser, Caroline Chiles
Summary: This study explores how to implement effective tobacco use treatment during lung cancer screening. Although there was a significant reduction in tobacco use over time, there was no difference between the intervention and control groups.
Article
Oncology
Mireia Diaz, Montse Garcia, Carmen Vidal, Albert Santiago, Gerard Gnutti, David Gomez, Marta Trapero-Bertran, Marcela Fu
Summary: Combining smoking cessation interventions with LDCT screening is a very attractive and cost-effective strategy for lung cancer prevention, significantly reducing the burden of the disease. Implementing intensive smoking cessation interventions at younger ages, combined with regular screening, is the most cost-effective approach in the European context.
Article
Oncology
Randi M. Williams, Marisa Cordon, Ellie Eyestone, Laney Smith, George Luta, Brady J. McKee, Shawn M. Regis, David B. Abrams, Raymond S. Niaura, Cassandra A. Stanton, Vicky Parikh, Kathryn L. Taylor
Summary: This study found that lung cancer screening could serve as a teachable moment for smoking cessation, with individuals who were extremely worried about lung cancer being more motivated to quit smoking and more ready to quit within the next 30 days.
Article
Oncology
Jacqueline V. Aredo, Sophia J. Luo, Rebecca M. Gardner, Nilotpal Sanyal, Eunji Choi, Thomas P. Hickey, Thomas L. Riley, Wen-Yi Huang, Allison W. Kurian, Ann N. Leung, Lynne R. Wilkens, Hilary A. Robbins, Elio Riboli, Rudolf Kaaks, Anne Tjonneland, Roel C. H. Vermeulen, Salvatore Panico, Loic Le Marchand, Christopher I. Amos, Rayjean J. Hung, Neal D. Freedman, Mattias Johansson, Iona Cheng, Heather A. Wakelee, Summer S. Han
Summary: The study revealed that smoking is a risk factor for second primary lung cancer (SPLC), and smoking cessation may reduce the risk of SPLC. Additionally, individuals who meet the U.S. Preventive Services Task Force's criteria at the diagnosis of initial primary lung cancer also have an increased risk of developing SPLC.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Review
Medicine, General & Internal
Richard Holliday, Bosun Hong, Elaine McColl, Jonathan Livingstone-Banks, Philip M. Preshaw
Summary: Dental professionals offering behavioral support can effectively help promote smoking cessation, especially when combined with pharmacotherapy. There is no evidence of oral health issues arising from interventions provided by dental professionals.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Oncology
Ugo Pastorino, Vito Ladisa, Sara Trussardo, Federica Sabia, Luigi Rolli, Camilla Valsecchi, Roberta E. Ledda, Gianluca Milanese, Paola Suatoni, Mattia Boeri, Gabriella Sozzi, Alfonso Marchiano, Elena Munarini, Roberto Boffi, Silvano Gallus, Giovanni Apolone
Summary: Cytisine, combined with counseling, is an effective and safe medication for smoking cessation, as demonstrated by a study in Italy. It significantly increases the quit rate and can be used to improve lung cancer screening outcomes.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Review
Oncology
Dana Moldovanu, Harry J. de Koning, Carlijn M. van der Aalst
Summary: Randomized-controlled trials have shown that low-dose computed tomography screening can reduce lung cancer mortality, but evidence on integrating smoking cessation support is lacking. Combining lung cancer screening with smoking cessation can significantly reduce mortality risk. Multi-modality interventions delivered by clinicians may be the most successful in influencing smoking behavior.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Review
Medicine, General & Internal
Scott J. Adams, Emily Stone, David R. Baldwin, Rozemarijn Vliegenthart, Pyng Lee, Florian J. Fintelmann
Summary: Randomised controlled trials have shown that low-dose CT lung cancer screening reduces mortality compared with chest radiography or no screening. However, uncertainties remain about optimizing clinical and cost effectiveness. This Review provides an international perspective on lung cancer screening, covering clinical trials, identification of individuals who benefit, management of screen-detected findings, smoking cessation interventions, cost-effectiveness, artificial intelligence and biomarkers, and challenges and opportunities in implementation.
Article
Oncology
Maria A. Lopez-Olivo, Jennifer A. Minnix, James G. Fox, Shawn P. E. Nishi, Lisa M. Lowenstein, Kristin G. Maki, Viola B. Leal, Ya-Chen Tina Shih, Paul M. Cinciripini, Robert J. Volk
Summary: Primary care providers often engage in smoking cessation counseling with their patients, but do not have a clear preference for type of treatment and rarely use follow-ups for quitting smoking. While many providers report shared decision-making about LCS, few use a decision aid for this conversation.
Article
Oncology
Hermine Poghosyan
Summary: This study investigated the relationship between patient-provider discussions about lung cancer screening and smoking quit attempts. The results indicated a significant association between discussions about lung cancer screening and smoking quit attempts.
ONCOLOGY NURSING FORUM
(2022)
Article
Medicine, General & Internal
Steven S. Fu, Alexander J. Rothman, David M. Vock, Bruce R. Lindgren, Daniel Almirall, Abbie Begnaud, Anne C. Melzer, Kelsey L. Schertz, Mariah Branson, David Haynes, Patrick Hammett, Anne M. Joseph
Summary: Adding a referral to prescription medication therapy management (MTM) to the tobacco longitudinal care (TLC) program showed positive effects among patients eligible for lung cancer screening (LCS) who did not respond to early treatment; however, decreasing the intensity of TLC among early treatment responders did not show significant improvement.
Article
Critical Care Medicine
Jane Turner, Gregory R. Pond, Alain Tremblay, Michael Johnston, Glen Goss, Garth Nicholas, Simon Martel, Rick Bhatia, Geoffrey Liu, Heidi Schmidt, Martin C. Tammemagi, Serge Puksa, Sukhinder Atkar-Khattra, Ming-Sound Tsao, Stephen Lam, John R. Goffin
Summary: The study found that perceived lung cancer risk was positively associated with calculated risk, but not consistently related to worry. Factors such as younger age and family history were associated with higher risk perception, as well as with lung cancer worry and reported intent to quit smoking. Promotion of screening programs may benefit from focusing on factors associated with higher risk perception.
Article
Oncology
Angela R. Bradbury, Ju-Whei Lee, Jill Bennett Gaieski, Shuli Li, Ilana F. Gareen, Keith T. Flaherty, Benjamin A. Herman, Susan M. Domchek, Angela M. DeMichele, Kara N. Maxwell, Adedayo A. Onitilo, Shamsuddin Virani, SuJung Park, Bryan A. Faller, Stefan C. Grant, Ryan C. Ramaekers, Robert J. Behrens, Gopakumar S. Nambudiri, Ruth C. Carlos, Lynne I. Wagner
Summary: This study found that patients who received genetic education before tumor genetic sequencing had increased understanding and reduced distress, particularly in women. However, the effects were not significant in men and patients with lower health literacy.
Article
Oncology
Sofia F. Garcia, Robert J. Gray, Joseph A. Sparano, Amye J. Tevaarwerk, Ruth C. Carlos, Betina Yanez, Ilana F. Gareen, Timothy J. Whelan, George W. Sledge, David Cella, Lynne I. Wagner
Summary: The study found that patients with early-stage breast cancer who received adjuvant chemoendocrine therapy reported greater fatigue and endocrine symptoms at early time points, but these differences lessened over time, demonstrating early chemotherapy effects more than long-term ones. Treatment arm differences in endocrine symptoms were more evident in postmenopausal patients.
Editorial Material
Oncology
Ruth C. Carlos, Samilia Obeng-Gyasi, Steven W. Cole, Bradley J. Zebrack, Etta D. Pisano, Melissa A. Troester, Lava Timsina, Lynne I. Wagner, Jon A. Steingrimsson, Ilana Gareen, Christoph I. Lee, Alyce S. Adams, Consuelo H. Wilkins
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Gelareh Sadigh, Robert J. Gray, Joseph A. Sparano, Betina Yanez, Sofia F. Garcia, Lava R. Timsina, Samilia Obeng-Gyasi, Ilana Gareen, George W. Sledge, Timothy J. Whelan, David Cella, Lynne Wagner, Ruth C. Carlos
Summary: This study evaluated the impact of racial disparities on clinical outcomes in breast cancer patients, showing that Black women had significantly shorter relapse-free interval and overall survival compared to White women. Factors such as insurance coverage and neighborhood deprivation index do not fully explain this disparity.
Article
Oncology
Samilia Obeng-Gyasi, Noah Graham, Shaji Kumar, Ju-Whei Lee, Susanna Jacobus, Matthias Weiss, David Cella, Fengmin Zhao, Edward H. Ip, Nathaniel O'Connell, Fangxin Hong, Devin J. Peipert, IIana. F. Gareen, Lava R. Timsina, Robert Gray, Lynne I. Wagner, Ruth C. Carlos
Summary: The objective of this study is to examine the association between neighborhood socioeconomic status (nSES) and baseline allostatic load (AL) and clinical trial endpoints in patients enrolled in the E1A11 therapeutic trial in multiple myeloma (MM). The study found that an increase in baseline AL was associated with higher odds of high fatigue at baseline and worse overall survival. Additionally, high nSES was associated with worse baseline bother. However, there was no association between AL or nSES and symptom burden, non-completion of induction therapy, or progression-free survival.
BLOOD CANCER JOURNAL
(2022)
Article
Medicine, General & Internal
Soudabeh Fazeli, Bradley S. Snyder, Ilana F. Gareen, Constance D. Lehman, Seema A. Khan, Justin Romanoff, Constantine A. Gatsonis, Ralph L. Corsetti, Habib Rahbar, Derrick W. Spell, Kenneth B. Blankstein, Linda K. Han, Jennifer L. Sabol, John R. Bumberry, Kathy D. Miller, Joseph A. Sparano, Christopher E. Comstock, Lynne Wagner, Ruth C. Carlos
Summary: This study found that patient preferences and receipt of surgery for DCIS were influenced by MRI results and surgeon recommendations. These findings emphasize the importance of ensuring adequate information and ongoing communication about the clinical significance of MRI findings and the benefits and risks of available treatment options.
Article
Oncology
Kelly A. Hyland, Sarah L. Eisel, Aasha I. Hoogland, James C. Root, Kris Bowles, Brian James, Ashley M. Nelson, Margaret Booth-Jones, Paul B. Jacobsen, Tim A. Ahles, Heather S. L. Jim, Brian D. Gonzalez
Summary: This controlled comparison study evaluated the cognitive function and symptoms of patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors. The study found that patients had worse overall neuropsychological performance and verbal memory compared to controls. Patients also reported greater fatigue, insomnia, and depressive symptoms, which were associated with worse subjective cognition.
LEUKEMIA & LYMPHOMA
(2023)
Article
Medicine, General & Internal
Ilana F. Gareen, Roee Gutman, JoRean Sicks, Tina D. Tailor, Richard M. Hoffman, Amal N. Trivedi, Efren Flores, Ellen Underwood, Jerson Cochancela, Caroline Chiles
Summary: This retrospective study analyzed the significant incidental findings (SIFs) in patients undergoing low-dose computed tomography (LDCT) lung screening. The study found a high prevalence of SIFs, most of which were considered reportable and required follow-up. Standardization of SIF reporting in future screening trials is recommended.
JAMA INTERNAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Kelly A. Hyland, Grace H. Amaden, Allison K. Diachina, Shannon N. Miller, Caroline S. Dorfman, Samuel I. Berchuck, Joseph G. Winger, Tamara J. Somers, Francis J. Keefe, Hope E. Uronis, Sarah A. Kelleher
Summary: A mobile health coping skills training program (mCOPE) was developed for early to mid-adulthood patients with colorectal cancer (CRC). The program utilizes cognitive behavioral therapy (CBT) and mHealth technology to reduce pain, fatigue, and distress and improve quality of life. A randomized controlled trial is being conducted to test the efficacy of mCOPE.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Meng-Yun Lin, Tao Liu, Constantine Gatsonis, JoRean D. Sicks, Stephannie Shih, Ruth C. Carlos, Ilana F. Gareen
Summary: This study examined the utilization patterns of diagnostic procedures after lung cancer screening among participants enrolled in the National Lung Screening Trial. The study found that the utilization of imaging and invasive procedures varied depending on the screening modality, with a lower utilization rate for low-dose CT compared to chest X-ray. The utilization of invasive and surgical procedures was also lower after subsequent screening examinations compared to baseline screening.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Vivek Narayan, Tao Liu, Yunjie Song, Joshua Mitchell, Jorean Sicks, Ilana F. Gareen, Lova Sun, Srinivas Denduluri, Ciaran P. Fisher, Jesse Manikowski, Mark Wojtowicz, Joseph Vadakara, Naomi Balzer Haas, Kenneth B. Margulies, Bonnie Ky
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Oncology
Fengmin Zhao, John Peipert, Vered Stearns, Victor Tsu-Shih Chang, Opeyemi Jegede, Edward Ip, Ju-Whei Lee, Nathaniel S. O'Connell, Noah Graham, Norah Lynn Henry, Charles L. Loprinzi, Patrick J. Flynn, Michael Jordan Fisch, Ilana F. Gareen, Ruth C. Carlos, Mary Lou Smith, David Cella, Joseph A. Sparano, Robert James Gray, Lynne I. Wagner
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Angela Wangari Walter, Ju-Whei Lee, Ilana F. Gareen, Sheetal Mehta Kircher, Benjamin A. Herman, Joanna M. Streck, Shaji Kumar, Ingrid A. Mayer, Nabil F. Saba, Joel W. Neal, Michael B. Atkins, F. Stephen Hodi, Christos Kyriakopoulos, Clare Tempany, Tait D. Shanafelt, Lynne I. Wagner, Stephanie R. Land, Jamie S. Ostroff, Elyse R. Park
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Etta Pisano, Constantine Gatsonis, Mitchell D. Schnall, Martin Yaffe, Melissa A. Troester, Ilana F. Gareen, Laura C. Collins, Amarinthia Curtis, Elodia B. Cole, Jean Cormack, Jon Steingrimsson, Ruth C. Carlos, Kathy Miller, Christopher Comstock
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Sheetal Mehta Kircher, Fenghai Duan, Ellen Underwood, Ilana F. Gareen, Jorean Sicks, Gelareh Sadigh, Jennifer Marie Suga, Heather Kehn, Paul Tracy Mehan, Rajesh Bajaj, David Sam Hanson, Samir Dalia, Jared David Acoba, Michael A. Taylor, Lynne I. Wagner, Ruth C. Carlos
JOURNAL OF CLINICAL ONCOLOGY
(2022)