期刊
ACS COMBINATORIAL SCIENCE
卷 16, 期 9, 页码 500-505出版社
AMER CHEMICAL SOC
DOI: 10.1021/co5000739
关键词
arylation; nitrobenzenesulfonamides; C-C bond formation; heterocycle; diversity-oriented synthesis
资金
- Department of Chemistry and Biochemistry of the University of Notre Dame
- European Social Fund [CZ.1.07/2.3.00/30.0060, CZ.1.07/2.4.00/17.0015]
Structural and electronic features that facilitate and direct the intramolecular C- and N-arylation of 2-alkyl-2-{[N-(benzyl)-2-nitrophenyl]sulfonamido}acetic acid esters and amides were examined. The substitution pattern and amino acid carboxy-terminal functionality determined the arylation position. C/N-arylated products represent advanced intermediates for combinatorial synthesis of diverse nitrogenous heterocycles, including indazoles, quinazolinones, quinoxalinones, and 3-amino-2-oxindoles.
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