期刊
ACS COMBINATORIAL SCIENCE
卷 14, 期 7, 页码 434-441出版社
AMER CHEMICAL SOC
DOI: 10.1021/co300042v
关键词
multicomponent reaction; heterocyclisation; 7-azaindoles; 2-aminopyrroles; aromatic aldehydes; active methylene compounds
资金
- BMBF REMEDIS-project Hohere Lebensqualitat durch neuartige Mikroimplantate [03IS2081A]
- DAAD
An efficient and practical route to 7-azaindole framework has been developed by one-pot, three-component cyclocondensation of N-substituted 2-amino-4-cyanopyrroles, various aldehydes, and active methylene compounds in ethanol or acetic acid at reflux. Reactions involving tetronic acid, indane-1,3-dione, dimedone, and 5-phenylcyclohexane-1,3-dione gave carbocyclic fused 7-azaindoles, whereas Meldrum's acid, benzoylacetonitrile, and malononitrile resulted in the highly substituted 7-azaindole derivatives, making this strategy very useful in diversity-oriented synthesis (DOS).
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