期刊
ACS CATALYSIS
卷 2, 期 4, 页码 561-564出版社
AMER CHEMICAL SOC
DOI: 10.1021/cs300069g
关键词
asymmetric hydrogenation; cyclic imine; iridium; phosphoramidite; Spiro catalyst; tetrahydroisoquinoline
资金
- National Natural Science Foundation of China
- National Basic Research Program of China [2010CB833300, 2012CB821600]
- Ministry of Education of China [B06005]
An efficient asymmetric hydrogenation of 1-alkyl 3,4-dihydroisoquinolines catalyzed by chiral Spiro iridium phosphoramidite complexes has been developed, providing very useful chiral 1-alkyl tetrahydroisoquinolines with high yields (88-96%) an good to excellent enantioselectivities (85-99% ee). This reaction also affords a convenient synthetic route to tetracyclic alkaloid (S)-xylopinine.
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