期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-06340-9
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资金
- Medical Research Council [MR/R001138/1]
- Wellcome-Trust [102051/Z/13/Z]
- intramural programme of the National Institute of Allergy and Infectious Disease/NIH
- PATH's Malaria Vaccines Initiative
- Wellcome Trust [102051/Z/13/Z] Funding Source: Wellcome Trust
- MRC [MR/R001138/1] Funding Source: UKRI
The quest to develop an effective malaria vaccine remains a major priority in the fight against global infectious disease. An approach with great potential is a transmission-blocking vaccine which induces antibodies that prevent establishment of a productive infection in mosquitos that feed on infected humans, thereby stopping the transmission cycle. One of the most promising targets for such a vaccine is the gamete surface protein, Pfs48/45. Here we establish a system for production of full-length Pfs48/45 and use this to raise a panel of monoclonal antibodies. We map the binding regions of these antibodies on Pfs48/45 and correlate the location of their epitopes with their transmission-blocking activity. Finally, we present the structure of the C-terminal domain of Pfs48/45 bound to the most potent transmission-blocking antibody, and provide key molecular information for future structure-guided immunogen design.
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